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Database: UniProt/TrEMBL
Entry: F0Z6K2_DICPU
LinkDB: F0Z6K2_DICPU
Original site: F0Z6K2_DICPU 
ID   F0Z6K2_DICPU            Unreviewed;       473 AA.
AC   F0Z6K2;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   03-MAY-2011, sequence version 1.
DT   25-OCT-2017, entry version 33.
DE   RecName: Full=Glutamate decarboxylase {ECO:0000256|RuleBase:RU361171};
DE            EC=4.1.1.15 {ECO:0000256|RuleBase:RU361171};
GN   Name=gadA {ECO:0000313|EMBL:EGC40506.1};
GN   ORFNames=DICPUDRAFT_146669 {ECO:0000313|EMBL:EGC40506.1};
OS   Dictyostelium purpureum (Slime mold).
OC   Eukaryota; Amoebozoa; Mycetozoa; Dictyosteliida; Dictyostelium.
OX   NCBI_TaxID=5786 {ECO:0000313|Proteomes:UP000001064};
RN   [1] {ECO:0000313|Proteomes:UP000001064}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=QSDP1 {ECO:0000313|Proteomes:UP000001064};
RX   PubMed=21356102; DOI=10.1186/gb-2011-12-2-r20;
RG   US DOE Joint Genome Institute (JGI-PGF);
RA   Sucgang R., Kuo A., Tian X., Salerno W., Parikh A., Feasley C.L.,
RA   Dalin E., Tu H., Huang E., Barry K., Lindquist E., Shapiro H.,
RA   Bruce D., Schmutz J., Salamov A., Fey P., Gaudet P., Anjard C.,
RA   Babu M.M., Basu S., Bushmanova Y., van der Wel H., Katoh-Kurasawa M.,
RA   Dinh C., Coutinho P.M., Saito T., Elias M., Schaap P., Kay R.R.,
RA   Henrissat B., Eichinger L., Rivero F., Putnam N.H., West C.M.,
RA   Loomis W.F., Chisholm R.L., Shaulsky G., Strassmann J.E.,
RA   Queller D.C., Kuspa A., Grigoriev I.V.;
RT   "Comparative genomics of the social amoebae Dictyostelium discoideum
RT   and Dictyostelium purpureum.";
RL   Genome Biol. 12:R20.1-R20.23(2011).
CC   -!- CATALYTIC ACTIVITY: L-glutamate = 4-aminobutanoate + CO(2).
CC       {ECO:0000256|RuleBase:RU361171}.
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC         Evidence={ECO:0000256|PIRSR:PIRSR602129-50,
CC         ECO:0000256|RuleBase:RU361171};
CC   -!- SIMILARITY: Belongs to the group II decarboxylase family.
CC       {ECO:0000256|RuleBase:RU361171}.
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DR   EMBL; GL870942; EGC40506.1; -; Genomic_DNA.
DR   RefSeq; XP_003283053.1; XM_003283005.1.
DR   STRING; 5786.XP_003283053.1; -.
DR   EnsemblProtists; EGC40506; EGC40506; DICPUDRAFT_146669.
DR   GeneID; 10503472; -.
DR   KEGG; dpp:DICPUDRAFT_146669; -.
DR   eggNOG; KOG1383; Eukaryota.
DR   eggNOG; COG0076; LUCA.
DR   InParanoid; F0Z6K2; -.
DR   KO; K01580; -.
DR   OMA; RPNLVMG; -.
DR   Proteomes; UP000001064; Unassembled WGS sequence.
DR   GO; GO:0005829; C:cytosol; IEA:EnsemblProtists.
DR   GO; GO:0004351; F:glutamate decarboxylase activity; IEA:UniProtKB-EC.
DR   GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR   GO; GO:0006536; P:glutamate metabolic process; IEA:InterPro.
DR   Gene3D; 3.40.640.10; -; 1.
DR   Gene3D; 3.90.1150.10; -; 1.
DR   InterPro; IPR010107; Glutamate_decarboxylase.
DR   InterPro; IPR002129; PyrdxlP-dep_de-COase.
DR   InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR   InterPro; IPR015421; PyrdxlP-dep_Trfase_major_sub1.
DR   InterPro; IPR015422; PyrdxlP-dep_Trfase_sub2.
DR   PANTHER; PTHR43321; PTHR43321; 1.
DR   Pfam; PF00282; Pyridoxal_deC; 1.
DR   SUPFAM; SSF53383; SSF53383; 1.
DR   TIGRFAMs; TIGR01788; Glu-decarb-GAD; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001064};
KW   Decarboxylase {ECO:0000256|RuleBase:RU361171};
KW   Lyase {ECO:0000256|RuleBase:RU361171};
KW   Pyridoxal phosphate {ECO:0000256|PIRSR:PIRSR602129-50,
KW   ECO:0000256|RuleBase:RU361171};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001064}.
FT   MOD_RES     284    284       N6-(pyridoxal phosphate)lysine.
FT                                {ECO:0000256|PIRSR:PIRSR602129-50}.
SQ   SEQUENCE   473 AA;  53824 MW;  149F8E5CB2943A56 CRC64;
     MSLHSIKSEN TKEKKGNSNK YKRCYDLYAE KSATHPINKY KINDHPTDPD LSKNLILDEL
     LLDGNAKQNL ATFCQTDVDI NIHTLMDKCI DKNMIDKDEY PQTAEIESRC VHMIADLWNS
     PDSANTIGCS TTGSSEAAML GGLALKWKWR EQRKKEGKPC DRPNLITGPV QICWHKFVLY
     FDIELREIPM ENGRLLMSPE EVLKRCDENT IGVVPTLGVT FTLQYENVRA ISDALDKYHK
     ETGLDIPIHV DAASGGFVAP FITPDLVWDF RLPRVKSINA SGHKYGLSPL GVGWVIWRGK
     EDIHKDLIFN VNYLGGNMPT FSLNFSRPGG QIVSQYYNFI RHGREGYRAI HQACIDHGVY
     IGEEIKKMGI FDLIYDGKGA LPGVCWLLKK DAKVKFNLFD LSDRMKTRGW QIASYTLPKN
     AESMIITRVL IRHGFSRDMA SLLIDDIKRC LEYFEKHPLV KPLSKEEGEG FHH
//
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