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Database: UniProt/TrEMBL
Entry: F1MIM3_BOVIN
LinkDB: F1MIM3_BOVIN
Original site: F1MIM3_BOVIN 
ID   F1MIM3_BOVIN            Unreviewed;       917 AA.
AC   F1MIM3;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 2.
DT   28-MAR-2018, entry version 52.
DE   SubName: Full=Hexokinase domain containing 1 {ECO:0000313|Ensembl:ENSBTAP00000044680};
GN   Name=HKDC1 {ECO:0000313|Ensembl:ENSBTAP00000044680,
GN   ECO:0000313|VGNC:VGNC:29867};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000044680, ECO:0000313|Proteomes:UP000009136};
RN   [1] {ECO:0000313|Ensembl:ENSBTAP00000044680, ECO:0000313|Proteomes:UP000009136}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000044680,
RC   ECO:0000313|Proteomes:UP000009136};
RX   PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42;
RA   Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C.,
RA   Puiu D., Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S.,
RA   Marcais G., Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.;
RT   "A whole-genome assembly of the domestic cow, Bos taurus.";
RL   Genome Biol. 10:R42.01-R42.10(2009).
RN   [2] {ECO:0000313|Ensembl:ENSBTAP00000044680}
RP   IDENTIFICATION.
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000044680};
RG   Ensembl;
RL   Submitted (MAR-2016) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the hexokinase family.
CC       {ECO:0000256|SAAS:SAAS00672880}.
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DR   EMBL; DAAA02061832; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001178413.1; NM_001191484.1.
DR   UniGene; Bt.1522; -.
DR   STRING; 9913.ENSBTAP00000044680; -.
DR   PaxDb; F1MIM3; -.
DR   Ensembl; ENSBTAT00000047474; ENSBTAP00000044680; ENSBTAG00000033398.
DR   GeneID; 614824; -.
DR   KEGG; bta:614824; -.
DR   CTD; 80201; -.
DR   VGNC; VGNC:29867; HKDC1.
DR   eggNOG; KOG1369; Eukaryota.
DR   eggNOG; COG5026; LUCA.
DR   GeneTree; ENSGT00390000017159; -.
DR   InParanoid; F1MIM3; -.
DR   KO; K00844; -.
DR   OMA; KIETRHV; -.
DR   OrthoDB; EOG091G08MD; -.
DR   TreeFam; TF314238; -.
DR   Proteomes; UP000009136; Chromosome 28.
DR   Bgee; ENSBTAG00000033398; -.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005739; C:mitochondrion; IEA:Ensembl.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0008865; F:fructokinase activity; IBA:GO_Central.
DR   GO; GO:0004340; F:glucokinase activity; IBA:GO_Central.
DR   GO; GO:0005536; F:glucose binding; IEA:InterPro.
DR   GO; GO:0019158; F:mannokinase activity; IBA:GO_Central.
DR   GO; GO:0001678; P:cellular glucose homeostasis; IBA:GO_Central.
DR   GO; GO:0006096; P:glycolytic process; IBA:GO_Central.
DR   InterPro; IPR001312; Hexokinase.
DR   InterPro; IPR019807; Hexokinase_BS.
DR   InterPro; IPR022673; Hexokinase_C.
DR   InterPro; IPR022672; Hexokinase_N.
DR   PANTHER; PTHR19443; PTHR19443; 4.
DR   Pfam; PF00349; Hexokinase_1; 2.
DR   Pfam; PF03727; Hexokinase_2; 2.
DR   PROSITE; PS00378; HEXOKINASE_1; 1.
DR   PROSITE; PS51748; HEXOKINASE_2; 2.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|SAAS:SAAS00672869};
KW   Complete proteome {ECO:0000313|Proteomes:UP000009136};
KW   Glycolysis {ECO:0000256|SAAS:SAAS00672870};
KW   Kinase {ECO:0000256|SAAS:SAAS00672871};
KW   Nucleotide-binding {ECO:0000256|SAAS:SAAS00672883};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW   Transferase {ECO:0000256|SAAS:SAAS00672884}.
FT   DOMAIN       22    219       Hexokinase_1. {ECO:0000259|Pfam:PF00349}.
FT   DOMAIN      225    459       Hexokinase_2. {ECO:0000259|Pfam:PF03727}.
FT   DOMAIN      470    666       Hexokinase_1. {ECO:0000259|Pfam:PF00349}.
FT   DOMAIN      672    906       Hexokinase_2. {ECO:0000259|Pfam:PF03727}.
SQ   SEQUENCE   917 AA;  102579 MW;  C6FA3C70CC00CFCE CRC64;
     MFAVHLMAFY FTKLKEDQIK KVDRFLYHMR LSDETLLDIM ARFQAEMQKG LGKDTNPTAS
     VKMLPTFVRA IPDGSENGEF LSLDLGGSKF RVLKVQVSEE GKRNVQMESQ FYPTPNEIIR
     GNGTELFEYV ADCLADFMKT KELMQKKLPL GLTFSFPCKQ TKLEEGILLS WTKKFKARGV
     QGTDVVSSLT NAMKRHQDLD VDILALVNDT VGTMMTCAYD DPYCEVGVII GTGTNACYME
     DMSNIDLVEG DEGRMCVNTE WGAFGDDGAL EDIRTEFDRE LDLGSLNPGK QLFEKMISGL
     YLGELVRLIL LKMAKAGLLF GGEKSSALHI KGKIETRHVA AMERYKEGLA NTREILTDLG
     LEPSDADCIA VQHVCTIVSF RSANLCAAAL AAILTRLREN KKLVRLRTTV GVDGTLYKIH
     PQYPKRLHKV VRKLVPNCDV RFLLSESGST KGAAMVTAVA SRLQAQRKQI DKVLALFRLT
     QEQLVGIRNK MRVEFEYGLK KDTHPLATVK MLPTYVCGMP DGTEKGKFLA LDLGGTNFRV
     LLVKIRSGRR SVRMYNKIFA IPLEIMQGTG EELFDHIVQC IADFLDYMGL KGAQLPLGFT
     FSFPCRQANI DKGTLIEWTK GFKATDCEGE DVVDMLREAI KRRNEFDLDI VAVVNDTVGT
     MMTCGYEDSN CEVGLIAGTG SNMCYMEEMR NIELVEGDEG KMCINTEWGG FGDNGCLDDI
     HTQYDKEVDE GSLNPGKQRY EKMTSGMYLG EIVRQILIDL TKQGLLFRGQ ISERLRTRGI
     FETKFLSQIE SDRLALLQVR RILQQLGLDS TCEDSIVVKE VCGAVSRRAA QLYGAGLAAI
     VEKRREDQGL EHMRITVGVD GTLYKLHPHF SRILRETVKE LAPQCDVMFM LSEDGSGKGA
     ALITAVAKRL QQAQREH
//
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