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Database: UniProt/TrEMBL
Entry: F1MW44_BOVIN
LinkDB: F1MW44_BOVIN
Original site: F1MW44_BOVIN 
ID   F1MW44_BOVIN            Unreviewed;       732 AA.
AC   F1MW44;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   03-MAY-2011, sequence version 1.
DT   28-MAR-2018, entry version 49.
DE   SubName: Full=Coagulation factor XIII A chain {ECO:0000313|Ensembl:ENSBTAP00000009559};
GN   Name=F13A1 {ECO:0000313|Ensembl:ENSBTAP00000009559,
GN   ECO:0000313|VGNC:VGNC:28680};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000009559, ECO:0000313|Proteomes:UP000009136};
RN   [1] {ECO:0000313|Ensembl:ENSBTAP00000009559, ECO:0000313|Proteomes:UP000009136}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000009559,
RC   ECO:0000313|Proteomes:UP000009136};
RX   PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42;
RA   Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C.,
RA   Puiu D., Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S.,
RA   Marcais G., Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.;
RT   "A whole-genome assembly of the domestic cow, Bos taurus.";
RL   Genome Biol. 10:R42.01-R42.10(2009).
RN   [2] {ECO:0000313|Ensembl:ENSBTAP00000009559}
RP   IDENTIFICATION.
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000009559};
RG   Ensembl;
RL   Submitted (MAR-2016) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC         Evidence={ECO:0000256|PIRSR:PIRSR000459-2};
CC       Note=Binds 1 Ca(2+) ion per subunit.
CC       {ECO:0000256|PIRSR:PIRSR000459-2};
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DR   EMBL; DAAA02055840; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; DAAA02055841; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; DAAA02055842; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; DAAA02055843; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; DAAA02055844; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; DAAA02055845; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001161366.1; NM_001167894.1.
DR   UniGene; Bt.19195; -.
DR   PRIDE; F1MW44; -.
DR   Ensembl; ENSBTAT00000009559; ENSBTAP00000009559; ENSBTAG00000007268.
DR   GeneID; 617881; -.
DR   KEGG; bta:617881; -.
DR   CTD; 2162; -.
DR   VGNC; VGNC:28680; F13A1.
DR   eggNOG; ENOG410IFMV; Eukaryota.
DR   eggNOG; ENOG410XQEZ; LUCA.
DR   GeneTree; ENSGT00760000119108; -.
DR   KO; K03917; -.
DR   OMA; CEEDAVY; -.
DR   OrthoDB; EOG091G030K; -.
DR   TreeFam; TF324278; -.
DR   Reactome; R-BTA-114608; Platelet degranulation.
DR   Reactome; R-BTA-140875; Common Pathway of Fibrin Clot Formation.
DR   Proteomes; UP000009136; Chromosome 23.
DR   Bgee; ENSBTAG00000007268; -.
DR   GO; GO:0003810; F:protein-glutamine gamma-glutamyltransferase activity; IEA:Ensembl.
DR   GO; GO:0072378; P:blood coagulation, fibrin clot formation; IEA:Ensembl.
DR   GO; GO:0018149; P:peptide cross-linking; IEA:Ensembl.
DR   Gene3D; 2.60.40.10; -; 3.
DR   Gene3D; 3.90.260.10; -; 1.
DR   InterPro; IPR034810; Factor_XIII_A.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR002931; Transglutaminase-like.
DR   InterPro; IPR036985; Transglutaminase-like_sf.
DR   InterPro; IPR023608; Transglutaminase_animal.
DR   InterPro; IPR013808; Transglutaminase_AS.
DR   InterPro; IPR008958; Transglutaminase_C.
DR   InterPro; IPR036238; Transglutaminase_C_sf.
DR   InterPro; IPR001102; Transglutaminase_N.
DR   PANTHER; PTHR11590:SF42; PTHR11590:SF42; 1.
DR   Pfam; PF00927; Transglut_C; 2.
DR   Pfam; PF01841; Transglut_core; 1.
DR   Pfam; PF00868; Transglut_N; 1.
DR   PIRSF; PIRSF000459; TGM_EBP42; 1.
DR   SMART; SM00460; TGc; 1.
DR   SUPFAM; SSF49309; SSF49309; 2.
DR   SUPFAM; SSF81296; SSF81296; 1.
DR   PROSITE; PS00547; TRANSGLUTAMINASES; 1.
PE   4: Predicted;
KW   Calcium {ECO:0000256|PIRSR:PIRSR000459-2};
KW   Complete proteome {ECO:0000313|Proteomes:UP000009136};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR000459-2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009136}.
FT   DOMAIN      307    400       TGc. {ECO:0000259|SMART:SM00460}.
FT   ACT_SITE    315    315       {ECO:0000256|PIRSR:PIRSR000459-1}.
FT   ACT_SITE    374    374       {ECO:0000256|PIRSR:PIRSR000459-1}.
FT   ACT_SITE    397    397       {ECO:0000256|PIRSR:PIRSR000459-1}.
FT   METAL       437    437       Calcium. {ECO:0000256|PIRSR:PIRSR000459-
FT                                2}.
FT   METAL       439    439       Calcium. {ECO:0000256|PIRSR:PIRSR000459-
FT                                2}.
FT   METAL       486    486       Calcium. {ECO:0000256|PIRSR:PIRSR000459-
FT                                2}.
FT   METAL       491    491       Calcium. {ECO:0000256|PIRSR:PIRSR000459-
FT                                2}.
SQ   SEQUENCE   732 AA;  82675 MW;  7C02DD47604BA08E CRC64;
     MSESSGTAFG GRRAIPPNTS NAAENDPPTV ELQGLVPRGF NPQDYLNVTN VHLFKERWDS
     NKVDHHTDKY SNDKLIVRRG QSFYIQIDFN RPYDPTRDLF RVEYVIGLYP QENKGTYIPV
     PLVSELQSGK WGAKVVMRED RSVRLSVQSS ADCIVGKFRM YVAVWTPYGV IRTSRNPETD
     TYILFNPWCE EDAVYLENEK EREECVLNDI GVIFYGDFND IKSRSWSYGQ FEDSILDACL
     FVMDKANMDL SGRGNPIKVS RVGSAMINAK DDEGVIAGSW DNVYAYGVPP SAWTGSVDIL
     LEYKSSQKPV RYGQCWVFAG VFNTFLRCLG IPARVVTNYF SAHDNDANLQ LDIFLEEDGN
     VNSKLTKDSV WNYHCWNEAW MTRPDLPVGF GGWQVVDSTP QENSDGMYRC GPASVQAIKH
     GHVCFQFDAP FVFAEVNSDL VYVTAKKDGT HVVEALDTTH IGKLIVTKEI GGDGMKDITD
     TYKFQEGQEE ERLALETAMM YGAKKALNTE GVLKSKSDVR MNFEVENAVL GRDLKVIITF
     RNNGSARYTV TAYLSGNISF YTGVSKAEFK NKTFEVTLEP LSFKREEVLI GAGEYMGQLL
     EQAFLHFFVT ARVNETRDVL AKQKSIALTV PKVVIKVRGA QVVGSDMVVT VEFTNPLKET
     LRNVWIRLDG PGVTKPLRKM FREIRPNSTV QWEELCRPWV SGPRKLIASL TSDSLRHVYG
     ELDLQIQRRP SM
//
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