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Database: UniProt/TrEMBL
Entry: F2QC42_STROU
LinkDB: F2QC42_STROU
Original site: F2QC42_STROU 
ID   F2QC42_STROU            Unreviewed;      1130 AA.
AC   F2QC42;
DT   31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   31-MAY-2011, sequence version 1.
DT   07-JUN-2017, entry version 47.
DE   SubName: Full=Neuraminidase A {ECO:0000313|EMBL:CBZ00210.1};
DE            EC=3.2.1.18 {ECO:0000313|EMBL:CBZ00210.1};
GN   Name=nanA {ECO:0000313|EMBL:CBZ00210.1};
GN   OrderedLocusNames=SOR_0548 {ECO:0000313|EMBL:CBZ00210.1};
OS   Streptococcus oralis (strain Uo5).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=927666 {ECO:0000313|EMBL:CBZ00210.1, ECO:0000313|Proteomes:UP000008131};
RN   [1] {ECO:0000313|EMBL:CBZ00210.1, ECO:0000313|Proteomes:UP000008131}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Uo5 {ECO:0000313|EMBL:CBZ00210.1,
RC   ECO:0000313|Proteomes:UP000008131};
RX   PubMed=21460080; DOI=10.1128/JB.00321-11;
RA   Reichmann P., Nuhn M., Denapaite D., Bruckner R., Henrich B.,
RA   Maurer P., Rieger M., Klages S., Reinhard R., Hakenbeck R.;
RT   "Genome of Streptococcus oralis strain Uo5.";
RL   J. Bacteriol. 193:2888-2889(2011).
CC   -!- SUBCELLULAR LOCATION: Secreted, cell wall
CC       {ECO:0000256|SAAS:SAAS00615689}; Peptidoglycan-anchor
CC       {ECO:0000256|SAAS:SAAS00615689}.
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DR   EMBL; FR720602; CBZ00210.1; -; Genomic_DNA.
DR   RefSeq; WP_013670178.1; NC_015291.1.
DR   STRING; 927666.SOR_0548; -.
DR   EnsemblBacteria; CBZ00210; CBZ00210; SOR_0548.
DR   KEGG; sor:SOR_0548; -.
DR   eggNOG; ENOG4108478; Bacteria.
DR   eggNOG; COG4409; LUCA.
DR   KO; K01186; -.
DR   OMA; TMHEGKE; -.
DR   OrthoDB; POG091H0EBR; -.
DR   Proteomes; UP000008131; Chromosome.
DR   GO; GO:0005618; C:cell wall; IEA:UniProtKB-SubCell.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IEA:InterPro.
DR   GO; GO:0052794; F:exo-alpha-(2->3)-sialidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0052795; F:exo-alpha-(2->6)-sialidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0052796; F:exo-alpha-(2->8)-sialidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   InterPro; IPR013320; ConA-like_dom.
DR   InterPro; IPR004124; Glyco_hydro_33_N.
DR   InterPro; IPR019948; Gram-positive_anchor.
DR   InterPro; IPR026856; Sialidase_fam.
DR   InterPro; IPR011040; Sialidases.
DR   InterPro; IPR005877; YSIRK_signal_dom.
DR   PANTHER; PTHR10628; PTHR10628; 1.
DR   Pfam; PF13088; BNR_2; 1.
DR   Pfam; PF00746; Gram_pos_anchor; 1.
DR   Pfam; PF02973; Sialidase; 1.
DR   Pfam; PF04650; YSIRK_signal; 1.
DR   SUPFAM; SSF49899; SSF49899; 1.
DR   SUPFAM; SSF50939; SSF50939; 2.
DR   TIGRFAMs; TIGR01168; YSIRK_signal; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000008131};
KW   Glycosidase {ECO:0000313|EMBL:CBZ00210.1};
KW   Hydrolase {ECO:0000313|EMBL:CBZ00210.1};
KW   Secreted {ECO:0000256|SAAS:SAAS00085696};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     38       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        39   1130       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003288640.
FT   DOMAIN        7     32       YSIRK_signal. {ECO:0000259|Pfam:PF04650}.
FT   DOMAIN      146    331       Sialidase. {ECO:0000259|Pfam:PF02973}.
FT   DOMAIN      562    785       Sialidases. {ECO:0000259|Pfam:PF13088}.
FT   DOMAIN     1091   1130       Gram_pos_anchor. {ECO:0000259|Pfam:
FT                                PF00746}.
SQ   SEQUENCE   1130 AA;  123945 MW;  24E86FADA6CAA9D2 CRC64;
     MNYKSLNRKQ RYGIRKFAVG AASVVIGTVV FGANPVLAQE QANAAGANTE TVEPGQGLSE
     LPKEASSGDL AHLDKDLAGK LAAAQDNGVV VDQDHLKKNE SAESETPSST GTLAEETNKE
     EESEDQGAIP RDYYSRDLKN ANPVLEKEDV ETNATNGQRV DLSSELNKLK QLKNATVHME
     FKPDASAPRF YNLFSVSSDT KENEYFTMSV LDNTALIEGR GANGEQFYDK YTDAPLKVRP
     GQWNSVTFTV EQPTAELPHG RVRLYVNGVL SRTSLKSGNF IKDMPDVNQA QLGATKRGNK
     TVWSSNLQVR NLTVYDRALS PDEVQTRSQL FERGELEQKL PEGAKVTEKE DVFEGGRNNQ
     PNKDGIKSYR IPALLKTDKG TLIAGTDERR LHHSDWGDIG MVVRRSSDNG KTWGDRIVIS
     NPRDNEHAKH AEWPSPVNID MALVQDPETK RIFAIYDMFL ESKAVFSLPG QAPKAYEQVG
     DKVYQVLYKQ GESGRYTIRE NGEVFDPQNR KTDYRVVVDP KKPAYSDKGD LYKGNELIGN
     IYFEYSEKNI FRVSNTNYLW MSYSDDDGKT WSAPKDITHG IRKDWMHFLG TGPGTGIALR
     TGPHKGRLVI PVYTTNNVSY LNGSQSSRVI YSDDHGETWQ AGEAVNDNRP VGNQTIHSST
     MNNPGAQNTE STVVQLNNGD LKLFMRGLTG DLQVATSHDG GATWDKEIKR YHQVKDVYVQ
     MSAIHTMHEG KEYILLSNAG GPGRNNGLVH LARVEANGEL TWLKHNPIQS GKFAYNSLQE
     LGNGEYGLLY EHADGNQNDY TLSYKKFNWD FLSKDRISPK EAKVKYAIQK WPGIIAMEFD
     SEVLVNKAPT LQLANGKTAT FMTQYDTKTL LFTIDPEDMG QRITGLAEGA IESMHNLPVS
     LAGSKLSDGI NGSEAAIHEV PEFTGGVNAE EAPVAEIPEY TGPLATVGEE PAPTVEKNEF
     TGGVNAEEAP VAEMPEYTGP LSTVGEEPAP TVEKPEFTGG INAVEAAVHE LPEFKGGVNA
     VLAASNELPE YRGGANFVLA ASNDLPEYKG GVNGAEAAVH ELPEYKGEIK PVLTAANDKL
     SLGQDVTYQA PAAKQDELPN TGSKETSSLL SLGLAGVLLS LFAFGKKRKE
//
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