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Database: UniProt/TrEMBL
Entry: F2Z672_YARLI
LinkDB: F2Z672_YARLI
Original site: F2Z672_YARLI 
ID   F2Z672_YARLI            Unreviewed;       534 AA.
AC   F2Z672;
DT   31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   31-MAY-2011, sequence version 1.
DT   05-JUL-2017, entry version 47.
DE   RecName: Full=Phosphotransferase {ECO:0000256|RuleBase:RU362007};
DE            EC=2.7.1.- {ECO:0000256|RuleBase:RU362007};
GN   ORFNames=YALI0_B22308g {ECO:0000313|EMBL:CAG83469.1};
OS   Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida
OS   lipolytica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Dipodascaceae; Yarrowia.
OX   NCBI_TaxID=284591 {ECO:0000313|EMBL:CAG83469.1, ECO:0000313|Proteomes:UP000001300};
RN   [1] {ECO:0000313|EMBL:CAG83469.1, ECO:0000313|Proteomes:UP000001300}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CLIB 122 / E 150 {ECO:0000313|Proteomes:UP000001300};
RX   PubMed=15229592; DOI=10.1038/nature02579;
RG   Genolevures;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S.,
RA   Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E.,
RA   Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V.,
RA   Barnay S., Blanchin S., Beckerich J.M., Beyne E., Bleykasten C.,
RA   Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A.,
RA   Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A.,
RA   Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R.,
RA   Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H.,
RA   Nicaud J.M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O.,
RA   Pellenz S., Potier S., Richard G.F., Straub M.L., Suleau A.,
RA   Swennene D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B.,
RA   Zeniou-Meyer M., Zivanovic I., Bolotin-Fukuhara M., Thierry A.,
RA   Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J.,
RA   Wincker P., Souciet J.L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- SIMILARITY: Belongs to the hexokinase family.
CC       {ECO:0000256|RuleBase:RU362007, ECO:0000256|SAAS:SAAS00672880}.
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DR   EMBL; CR382128; CAG83469.1; -; Genomic_DNA.
DR   RefSeq; XP_501216.1; XM_501216.1.
DR   ProteinModelPortal; F2Z672; -.
DR   SMR; F2Z672; -.
DR   STRING; 4952.XP_501216.1; -.
DR   EnsemblFungi; CAG83469; CAG83469; YALI0_B22308g.
DR   GeneID; 2906865; -.
DR   KEGG; yli:YALI0B22308g; -.
DR   InParanoid; F2Z672; -.
DR   KO; K00844; -.
DR   OMA; ERQFFRA; -.
DR   OrthoDB; EOG092C2JW4; -.
DR   Proteomes; UP000001300; Chromosome B.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IEA:EnsemblFungi.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0008865; F:fructokinase activity; IBA:GO_Central.
DR   GO; GO:0004340; F:glucokinase activity; IBA:GO_Central.
DR   GO; GO:0005536; F:glucose binding; IEA:InterPro.
DR   GO; GO:0019158; F:mannokinase activity; IBA:GO_Central.
DR   GO; GO:0001678; P:cellular glucose homeostasis; IBA:GO_Central.
DR   GO; GO:0006002; P:fructose 6-phosphate metabolic process; IEA:EnsemblFungi.
DR   GO; GO:0006000; P:fructose metabolic process; IEA:EnsemblFungi.
DR   GO; GO:0006006; P:glucose metabolic process; IEA:EnsemblFungi.
DR   GO; GO:0006096; P:glycolytic process; IBA:GO_Central.
DR   GO; GO:0006013; P:mannose metabolic process; IEA:EnsemblFungi.
DR   InterPro; IPR001312; Hexokinase.
DR   InterPro; IPR019807; Hexokinase_BS.
DR   InterPro; IPR022673; Hexokinase_C.
DR   InterPro; IPR022672; Hexokinase_N.
DR   PANTHER; PTHR19443; PTHR19443; 1.
DR   Pfam; PF00349; Hexokinase_1; 1.
DR   Pfam; PF03727; Hexokinase_2; 1.
DR   PROSITE; PS00378; HEXOKINASE_1; 1.
DR   PROSITE; PS51748; HEXOKINASE_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|RuleBase:RU362007,
KW   ECO:0000256|SAAS:SAAS00672869};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001300};
KW   Glycolysis {ECO:0000256|RuleBase:RU362007,
KW   ECO:0000256|SAAS:SAAS00672870};
KW   Kinase {ECO:0000256|RuleBase:RU362007, ECO:0000256|SAAS:SAAS00672871};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU362007,
KW   ECO:0000256|SAAS:SAAS00672883};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001300};
KW   Transferase {ECO:0000256|RuleBase:RU362007,
KW   ECO:0000256|SAAS:SAAS00672884}.
FT   DOMAIN       27    257       Hexokinase_1. {ECO:0000259|Pfam:PF00349}.
FT   DOMAIN      264    512       Hexokinase_2. {ECO:0000259|Pfam:PF03727}.
SQ   SEQUENCE   534 AA;  59174 MW;  F51F75E03EE2600E CRC64;
     MVHLGPRKPP SRKGSMADVP RDLLEQISQL ETIFTVSPEK LRQITDHFVS ELAKGLTKEG
     GDIPMNPTWI LGWPTGKESG CYLALDMGGT NLRVVKVTLD GDRGFDVMQS KYHMPPNIKV
     GKQEELWEYI AECLGKFLAD NYPEALDAHE RGRDVDRTAA QSFTRDKSPP PHNQHISCSP
     GFDIHKIPLG FTFSYPCSQP AVNRGVLQRW TKGFDIEGVE GEDVVPMLEA ALERKNIPIS
     ITALINDTTG TMVASNYHDP QIKLGNIFGT GVNAAYYEKV KDIPKLKGLI PDSIDPETPM
     AVNCEYGAFD NEHKVLPRTK WDIIIDEESP RPGQQTFEKM SAGYYLGELL RLVLLDLYKD
     GFVFENQGKN GQELGNGNIN KSYFFDTSFL SLIEEDPWEN LTDVEILFKE KLGINTTEPE
     RKLIRRLAEL IGTRSARISA CGVAAICKKA GYKEAHAGAD GSVFNKYPGF KERGAQALNE
     IFEWNLPNPK DHPIKIVPAE DGSGVGAALC AALTIKRVKQ GLPVGVKPGV KYDI
//
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