ID F4B7K0_ACIHW Unreviewed; 326 AA.
AC F4B7K0;
DT 28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT 28-JUN-2011, sequence version 1.
DT 29-MAY-2013, entry version 11.
DE RecName: Full=Probable methylcobalamin:homocysteine methyltransferase;
DE EC=2.1.1.-;
DE AltName: Full=Methionine synthase;
GN Name=metE; OrderedLocusNames=Ahos_0718;
OS Acidianus hospitalis (strain W1).
OC Archaea; Crenarchaeota; Thermoprotei; Sulfolobales; Sulfolobaceae;
OC Acidianus.
OX NCBI_TaxID=933801;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=W1;
RX PubMed=21607549; DOI=10.1007/s00792-011-0379-y;
RA You X.Y., Liu C., Wang S.Y., Jiang C.Y., Shah S.A., Prangishvili D.,
RA She Q., Liu S.J., Garrett R.A.;
RT "Genomic analysis of Acidianus hospitalis W1 a host for studying
RT crenarchaeal virus and plasmid life cycles.";
RL Extremophiles 15:487-497(2011).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=W1;
RA You X.Y., Liu C., Wang S.Y., Jiang C.Y., Shah S.A., Prangishvili D.,
RA Liu S.J., Garrett R.A.;
RT "Genomic analyses of Acidianus hospitalis W1 a host for studying
RT crenarchaeal virus and plasmid life cycles.";
RL Extremophiles 0:0-0(2011).
CC -!- FUNCTION: Catalyzes the transfer of a methyl group from
CC methylcobalamin and methylcobinamide to homocysteine resulting in
CC methionine formation (By similarity).
CC -!- COFACTOR: Binds 1 zinc ion per subunit (By similarity).
CC -!- PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via de
CC novo pathway.
CC -!- SIMILARITY: Belongs to the vitamin-B12 independent methionine
CC synthase family.
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DR EMBL; CP002535; AEE93605.1; -; Genomic_DNA.
DR RefSeq; YP_004457903.1; NC_015518.1.
DR EnsemblBacteria; AEE93605; AEE93605; Ahos_0718.
DR GeneID; 10600172; -.
DR KEGG; aho:Ahos_0718; -.
DR KO; K00549; -.
DR BioCyc; AHOS933801:GHY6-733-MONOMER; -.
DR UniPathway; UPA00051; -.
DR GO; GO:0003871; F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0009086; P:methionine biosynthetic process; IEA:HAMAP.
DR HAMAP; MF_00288; MetE; 1; -.
DR InterPro; IPR022921; MetE_arc.
DR InterPro; IPR002629; Methionine_synth.
DR Pfam; PF01717; Meth_synt_2; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis; Complete proteome; Metal-binding;
KW Methionine biosynthesis; Methyltransferase; Transferase; Zinc.
FT METAL 211 211 Zinc (By similarity).
FT METAL 213 213 Zinc (By similarity).
FT METAL 296 296 Zinc (By similarity).
SQ SEQUENCE 326 AA; 37476 MW; BB23E9A2DF4D39F4 CRC64;
MDELPILPTT VIGSYPRPKW LREAIRLHKA GKVSDEELTE AFNDAALAVL HDHYLAGIDV
PTDGEVKRDE MVEYFAERLG GFKFYGPVRV WGTAYYRKPA VVGKIEYKSP LLVDEFNYTK
SVSYTPNVKI TITGPYTIAY WSYNEYYKDM KDLVFDLAKI INKELHNLVD AGARIIQIDE
PAIHSNKKDV SWAVEAVNEA VKGINAKLVV HICYGDYRIV APYLNEFKVD QINFALKIYN
YRYLELFKKY GYEKELGLGV IDVHSRRVES AEEVAKDIKN SLEYFPAEKI WINPDCGLKL
LPRSIAFQKL VNMVKGTKMV REELKK
//
