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Database: UniProt/TrEMBL
Entry: F4B7K0_ACIHW
LinkDB: F4B7K0_ACIHW
Original site: F4B7K0_ACIHW 
ID   F4B7K0_ACIHW            Unreviewed;       326 AA.
AC   F4B7K0;
DT   28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT   28-JUN-2011, sequence version 1.
DT   19-FEB-2014, entry version 13.
DE   RecName: Full=Probable methylcobalamin:homocysteine methyltransferase;
DE            EC=2.1.1.-;
DE   AltName: Full=Methionine synthase;
GN   Name=metE; OrderedLocusNames=Ahos_0718;
OS   Acidianus hospitalis (strain W1).
OC   Archaea; Crenarchaeota; Thermoprotei; Sulfolobales; Sulfolobaceae;
OC   Acidianus.
OX   NCBI_TaxID=933801;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=W1;
RX   PubMed=21607549; DOI=10.1007/s00792-011-0379-y;
RA   You X.Y., Liu C., Wang S.Y., Jiang C.Y., Shah S.A., Prangishvili D.,
RA   She Q., Liu S.J., Garrett R.A.;
RT   "Genomic analysis of Acidianus hospitalis W1 a host for studying
RT   crenarchaeal virus and plasmid life cycles.";
RL   Extremophiles 15:487-497(2011).
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=W1;
RA   You X.Y., Liu C., Wang S.Y., Jiang C.Y., Shah S.A., Prangishvili D.,
RA   Liu S.J., Garrett R.A.;
RT   "Genomic analyses of Acidianus hospitalis W1 a host for studying
RT   crenarchaeal virus and plasmid life cycles.";
RL   Extremophiles 0:0-0(2011).
CC   -!- FUNCTION: Catalyzes the transfer of a methyl group from
CC       methylcobalamin and methylcobinamide to homocysteine resulting in
CC       methionine formation (By similarity).
CC   -!- COFACTOR: Binds 1 zinc ion per subunit (By similarity).
CC   -!- PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via de
CC       novo pathway.
CC   -!- SIMILARITY: Belongs to the vitamin-B12 independent methionine
CC       synthase family.
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DR   EMBL; CP002535; AEE93605.1; -; Genomic_DNA.
DR   RefSeq; YP_004457903.1; NC_015518.1.
DR   EnsemblBacteria; AEE93605; AEE93605; Ahos_0718.
DR   GeneID; 10600172; -.
DR   KEGG; aho:Ahos_0718; -.
DR   KO; K00549; -.
DR   OMA; NYYLLAD; -.
DR   BioCyc; AHOS933801:GHY6-733-MONOMER; -.
DR   UniPathway; UPA00051; -.
DR   GO; GO:0003871; F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-HAMAP.
DR   HAMAP; MF_00288; MetE; 1.
DR   InterPro; IPR022921; MetE_arc.
DR   InterPro; IPR002629; Methionine_synth.
DR   Pfam; PF01717; Meth_synt_2; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Complete proteome; Metal-binding;
KW   Methionine biosynthesis; Methyltransferase; Transferase; Zinc.
FT   METAL       211    211       Zinc (By similarity).
FT   METAL       213    213       Zinc (By similarity).
FT   METAL       296    296       Zinc (By similarity).
SQ   SEQUENCE   326 AA;  37476 MW;  BB23E9A2DF4D39F4 CRC64;
     MDELPILPTT VIGSYPRPKW LREAIRLHKA GKVSDEELTE AFNDAALAVL HDHYLAGIDV
     PTDGEVKRDE MVEYFAERLG GFKFYGPVRV WGTAYYRKPA VVGKIEYKSP LLVDEFNYTK
     SVSYTPNVKI TITGPYTIAY WSYNEYYKDM KDLVFDLAKI INKELHNLVD AGARIIQIDE
     PAIHSNKKDV SWAVEAVNEA VKGINAKLVV HICYGDYRIV APYLNEFKVD QINFALKIYN
     YRYLELFKKY GYEKELGLGV IDVHSRRVES AEEVAKDIKN SLEYFPAEKI WINPDCGLKL
     LPRSIAFQKL VNMVKGTKMV REELKK
//
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