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Database: UniProt/TrEMBL
Entry: F4DT94_PSEMN
LinkDB: F4DT94_PSEMN
Original site: F4DT94_PSEMN 
ID   F4DT94_PSEMN            Unreviewed;       742 AA.
AC   F4DT94;
DT   28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT   28-JUN-2011, sequence version 1.
DT   07-JUN-2017, entry version 33.
DE   SubName: Full=Isocitrate dehydrogenase, NADP-dependent {ECO:0000313|EMBL:AEB58404.1};
GN   OrderedLocusNames=MDS_2373 {ECO:0000313|EMBL:AEB58404.1};
OS   Pseudomonas mendocina (strain NK-01).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=1001585 {ECO:0000313|EMBL:AEB58404.1, ECO:0000313|Proteomes:UP000008306};
RN   [1] {ECO:0000313|EMBL:AEB58404.1, ECO:0000313|Proteomes:UP000008306}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NK-01 {ECO:0000313|EMBL:AEB58404.1,
RC   ECO:0000313|Proteomes:UP000008306};
RX   PubMed=21551299; DOI=10.1128/JB.05068-11;
RA   Guo W., Wang Y., Song C., Yang C., Li Q., Li B., Su W., Sun X.,
RA   Song D., Yang X., Wang S.;
RT   "Complete genome of Pseudomonas mendocina NK-01, which synthesizes
RT   medium-chain-length polyhydroxyalkanoates and alginate
RT   oligosaccharides.";
RL   J. Bacteriol. 193:3413-3414(2011).
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Note=Binds 1 Mg(2+) or Mn(2+) ion per subunit.
CC       {ECO:0000256|PIRSR:PIRSR009407-3};
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DR   EMBL; CP002620; AEB58404.1; -; Genomic_DNA.
DR   RefSeq; WP_013715495.1; NC_015410.1.
DR   STRING; 1001585.MDS_2373; -.
DR   EnsemblBacteria; AEB58404; AEB58404; MDS_2373.
DR   KEGG; pmk:MDS_2373; -.
DR   eggNOG; ENOG4105E9K; Bacteria.
DR   eggNOG; COG2838; LUCA.
DR   KO; K00031; -.
DR   OMA; RDSGKMW; -.
DR   BioCyc; PMEN1001585:GIWS-2401-MONOMER; -.
DR   Proteomes; UP000008306; Chromosome.
DR   GO; GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR   InterPro; IPR004436; Isocitrate_DH_NADP_mono.
DR   Pfam; PF03971; IDH; 1.
DR   PIRSF; PIRSF009407; IDH_monmr; 1.
DR   TIGRFAMs; TIGR00178; monomer_idh; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000008306};
KW   Magnesium {ECO:0000256|PIRSR:PIRSR009407-3};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   REGION      133    140       Substrate binding. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   METAL       350    350       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       548    548       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       552    552       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   BINDING     146    146       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   BINDING     547    547       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   SITE        255    255       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
FT   SITE        420    420       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
SQ   SEQUENCE   742 AA;  81912 MW;  50542F4228DA5EA3 CRC64;
     MSTPSKIIYT FTDEAPALAT YSLLPIVEAF AASADISVET RDISLAGRIL ASFADRLDAD
     KRIDDDLAKL AELTLQPDAN IIKLPNISAS VPQLKAAIAE LQAQGYNIPD FPEDPQSEED
     KEVRARYAKV LGSAVNPVLR EGNSDRRAPA AVKAYARKHP HSMGKWSMAS QSHADYMRGG
     DFFSSEQSIT MAKAGDVRIE FVGKDGKVEV KKQLALQEGE VFDSMFMSCR KLRAFFEKTL
     QDCKETGVMW SLHVKATMMK VSHPIVFGHA VSVYYKDVFD KYGDLFKELG VNPNNGISSV
     YDKIKSLPAS QQEEILHDIH EVYAHRPEMA MVDSVKGITN LHIPSDVIVD ASMPAMIRNS
     GQMWGKDGKQ KDTKAVMPES TYARIYQEMI NFCKTNGAFD PTTMGSVPNV GLMAQKAEEY
     GSHDKTFEMT ADGTMRVVAA DGTVLMQHEV EAGDIWRACQ TKDAPIRDWV KLAVTRARQS
     DTPAIFWLDP ERAHDRELQK KVELYLKDHD LTGLDIRMMG YNEAIRVSME RMIRGQDTIS
     VTGNVLRDYL TDLFPIMELG TSAKMLSIVP LMAGGGMYET GAGGSAPKHV QQLVEENYLR
     WDSLGEFLAL AVSLEETGIK TNNAKAKVLG KTLDQATGKL LDNNKSPARK VGEIDNRGSH
     FYLALYWAQA LAEQNDDAEL KAHFAPLAKQ LTEQEATIVA ELAAVQGKPA EIGGYYRSNP
     ELTSKVMRPS TTFNAALAAL NA
//
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