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Database: UniProt/TrEMBL
Entry: F4GDD6_ALIDK
LinkDB: F4GDD6_ALIDK
Original site: F4GDD6_ALIDK 
ID   F4GDD6_ALIDK            Unreviewed;       316 AA.
AC   F4GDD6;
DT   28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT   28-JUN-2011, sequence version 1.
DT   26-NOV-2014, entry version 21.
DE   RecName: Full=Homoserine kinase {ECO:0000256|HAMAP-Rule:MF_00301, ECO:0000256|SAAS:SAAS00085804};
DE            Short=HK {ECO:0000256|HAMAP-Rule:MF_00301};
DE            Short=HSK {ECO:0000256|HAMAP-Rule:MF_00301};
DE            EC=2.7.1.39 {ECO:0000256|HAMAP-Rule:MF_00301, ECO:0000256|SAAS:SAAS00085809};
GN   Name=thrB {ECO:0000256|HAMAP-Rule:MF_00301};
GN   OrderedLocusNames=Alide2_3640 {ECO:0000313|EMBL:AEB85965.1};
OS   Alicycliphilus denitrificans (strain DSM 14773 / CIP 107495 / K601).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Comamonadaceae; Alicycliphilus.
OX   NCBI_TaxID=596154 {ECO:0000313|EMBL:AEB85965.1, ECO:0000313|Proteomes:UP000007938};
RN   [1] {ECO:0000313|EMBL:AEB85965.1, ECO:0000313|Proteomes:UP000007938}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 14773 / CIP 107495 / K601
RC   {ECO:0000313|Proteomes:UP000007938};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA   Peters L., Zeytun A., Detter J.C., Han C., Tapia R., Land M.,
RA   Hauser L., Kyrpides N., Ivanova N., Mikhailova N., Pagani I.,
RA   Oosterkamp M., Pieper D., van Berkel W., Langenhoff A., Smidt H.,
RA   Stams A., Woyke T.;
RT   "Complete sequence of chromosome of Alicycliphilus denitrificans
RT   K601.";
RL   Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: ATP + L-homoserine = ADP + O-phospho-L-
CC       homoserine. {ECO:0000256|HAMAP-Rule:MF_00301,
CC       ECO:0000256|SAAS:SAAS00085813}.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-threonine biosynthesis; L-
CC       threonine from L-aspartate: step 4/5. {ECO:0000256|HAMAP-
CC       Rule:MF_00301, ECO:0000256|SAAS:SAAS00085805}.
CC   -!- SIMILARITY: Belongs to the pseudomonas-type ThrB family.
CC       {ECO:0000256|HAMAP-Rule:MF_00301}.
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DR   EMBL; CP002657; AEB85965.1; -; Genomic_DNA.
DR   RefSeq; YP_004389481.1; NC_015422.1.
DR   EnsemblBacteria; AEB85965; AEB85965; Alide2_3640.
DR   GeneID; 10484701; -.
DR   KEGG; adk:Alide2_3640; -.
DR   PATRIC; 54530006; VBIAliDen79014_3663.
DR   KO; K02204; -.
DR   BioCyc; ADEN596154:GHU6-3686-MONOMER; -.
DR   UniPathway; UPA00050; UER00064.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004413; F:homoserine kinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009088; P:threonine biosynthetic process; IEA:UniProtKB-UniPathway.
DR   HAMAP; MF_00301; Homoser_kinase_2; 1.
DR   InterPro; IPR002575; Aminoglycoside_PTrfase.
DR   InterPro; IPR005280; Homoserine_kinase_ThrB.
DR   InterPro; IPR011009; Kinase-like_dom.
DR   Pfam; PF01636; APH; 1.
DR   SUPFAM; SSF56112; SSF56112; 1.
DR   TIGRFAMs; TIGR00938; thrB_alt; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|HAMAP-Rule:MF_00301,
KW   ECO:0000256|SAAS:SAAS00085810};
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00301,
KW   ECO:0000256|SAAS:SAAS00085806};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007938};
KW   Kinase {ECO:0000256|HAMAP-Rule:MF_00301,
KW   ECO:0000256|SAAS:SAAS00085814};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00301,
KW   ECO:0000256|SAAS:SAAS00085815};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007938};
KW   Threonine biosynthesis {ECO:0000256|HAMAP-Rule:MF_00301,
KW   ECO:0000256|SAAS:SAAS00085807};
KW   Transferase {ECO:0000256|HAMAP-Rule:MF_00301,
KW   ECO:0000256|SAAS:SAAS00085812}.
SQ   SEQUENCE   316 AA;  35270 MW;  91E9CD0E39996ACE CRC64;
     MAVFTEVSSK EASDLLRRLQ LGELLALRGI EGGIENTNYF VTSEQGEYVL TLFERLTFEQ
     LPFYLHLMKH LAHAGIPVPD PQADMHGEIL HTVAGKPAAL ATKLRGKSQL APQAAHCAAV
     GTLLARMHLA ARDYERQQPN LRGLPWWNET VPVVLPHVGP GQAALLQSEL AYQNHVAAGS
     GYAALPRGPI HADLFRDNVM FEGTELTGCF DFYFAGVDTW LFDLAVCLND WCIDLPTGRH
     DGERTAAMLA AYQAVRPLTA AERELLPAML RAGALRFWIS RLWDFHLPRQ ASMLKPHDPA
     HFERVLRERV RHPVHP
//
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