LinkDB: F5HLR4_ANOGA Q7Q9A8_ANOGA
Original site: F5HLR4_ANOGA Q7Q9A8_ANOGA
ID F5HLR4_ANOGA Unreviewed; 650 AA. AC F5HLR4; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 24-JAN-2024, entry version 74. DE RecName: Full=phosphoenolpyruvate carboxykinase (GTP) {ECO:0000256|ARBA:ARBA00012306}; DE EC=4.1.1.32 {ECO:0000256|ARBA:ARBA00012306}; GN Name=1275028 {ECO:0000313|EnsemblMetazoa:AGAP003350-PB}; GN ORFNames=AgaP_AGAP003350 {ECO:0000313|EMBL:EGK97225.1}; OS Anopheles gambiae (African malaria mosquito). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae; OC Anophelinae; Anopheles. OX NCBI_TaxID=7165 {ECO:0000313|EMBL:EGK97225.1}; RN [1] {ECO:0000313|EMBL:EGK97225.1, ECO:0000313|Proteomes:UP000007062} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=PEST {ECO:0000313|EMBL:EGK97225.1, RC ECO:0000313|Proteomes:UP000007062}; RX PubMed=12364791; DOI=10.1126/science.1076181; RA Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R., RA Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R., RA Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z., RA Kraft C.L., Abril J.F., Anthouard V., Arensburger P., Atkinson P.W., RA Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C., RA Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K., RA Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V., RA Dana A., Delcher A., Dew I., Evans C.A., Flanigan M., RA Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R., RA Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J., RA Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I., RA Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A., RA McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D., RA O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H., RA Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J., RA Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B., RA Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M., RA Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I., RA Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J., RA Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M., RA Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C., RA Collins F.H., Hoffman S.L.; RT "The genome sequence of the malaria mosquito Anopheles gambiae."; RL Science 298:129-149(2002). RN [2] {ECO:0000313|EMBL:EGK97225.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=PEST {ECO:0000313|EMBL:EGK97225.1}; RG The Anopheles Genome Sequencing Consortium; RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|EMBL:EGK97225.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=PEST {ECO:0000313|EMBL:EGK97225.1}; RX PubMed=14747013; DOI=10.1016/j.pt.2003.11.003; RA Mongin E., Louis C., Holt R.A., Birney E., Collins F.H.; RT "The Anopheles gambiae genome: an update."; RL Trends Parasitol. 20:49-52(2004). RN [4] {ECO:0000313|EMBL:EGK97225.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=PEST {ECO:0000313|EMBL:EGK97225.1}; RX PubMed=17210077; DOI=10.1186/gb-2007-8-1-r5; RA Sharakhova M.V., Hammond M.P., Lobo N.F., Krzywinski J., Unger M.F., RA Hillenmeyer M.E., Bruggner R.V., Birney E., Collins F.H.; RT "Update of the Anopheles gambiae PEST genome assembly."; RL Genome Biol. 8:R5.1-R5.13(2007). RN [5] {ECO:0000313|EMBL:EGK97225.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=PEST {ECO:0000313|EMBL:EGK97225.1}; RG VectorBase; RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases. RN [6] {ECO:0000313|EnsemblMetazoa:AGAP003350-PB} RP IDENTIFICATION. RC STRAIN=PEST {ECO:0000313|EnsemblMetazoa:AGAP003350-PB}; RG EnsemblMetazoa; RL Submitted (MAY-2020) to UniProtKB. CC -!- COFACTOR: CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035; CC Evidence={ECO:0000256|ARBA:ARBA00001936}; CC -!- SIMILARITY: Belongs to the phosphoenolpyruvate carboxykinase [GTP] CC family. {ECO:0000256|ARBA:ARBA00005796}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AAAB01008904; EGK97225.1; -; Genomic_DNA. DR RefSeq; XP_003436452.1; XM_003436404.1. DR AlphaFoldDB; F5HLR4; -. DR SMR; F5HLR4; -. DR STRING; 7165.F5HLR4; -. DR PaxDb; 7165-AGAP003350-PB; -. DR EnsemblMetazoa; AGAP003350-RB; AGAP003350-PB; AGAP003350. DR GeneID; 1275028; -. DR KEGG; aga:AgaP_AGAP003350; -. DR VEuPathDB; VectorBase:AGAP003350; -. DR eggNOG; KOG3749; Eukaryota. DR HOGENOM; CLU_028872_1_1_1; -. DR InParanoid; F5HLR4; -. DR OMA; TRQIMSF; -. DR OrthoDB; 5471652at2759; -. DR Proteomes; UP000007062; Chromosome 2R. DR GO; GO:0005829; C:cytosol; IBA:GO_Central. DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW. DR GO; GO:0030145; F:manganese ion binding; IBA:GO_Central. DR GO; GO:0004613; F:phosphoenolpyruvate carboxykinase (GTP) activity; IBA:GO_Central. DR GO; GO:0071549; P:cellular response to dexamethasone stimulus; IBA:GO_Central. DR GO; GO:0071333; P:cellular response to glucose stimulus; IBA:GO_Central. DR GO; GO:0032869; P:cellular response to insulin stimulus; IBA:GO_Central. DR GO; GO:0006094; P:gluconeogenesis; IBA:GO_Central. DR GO; GO:0046327; P:glycerol biosynthetic process from pyruvate; IBA:GO_Central. DR GO; GO:0019543; P:propionate catabolic process; IBA:GO_Central. DR GO; GO:0042594; P:response to starvation; IBA:GO_Central. DR CDD; cd00819; PEPCK_GTP; 1. DR Gene3D; 3.90.228.20; -; 1. DR Gene3D; 3.40.449.10; Phosphoenolpyruvate Carboxykinase, domain 1; 1. DR Gene3D; 2.170.8.10; Phosphoenolpyruvate Carboxykinase, domain 2; 1. DR HAMAP; MF_00452; PEPCK_GTP; 1. DR InterPro; IPR018091; PEP_carboxykin_GTP_CS. DR InterPro; IPR013035; PEP_carboxykinase_C. DR InterPro; IPR008209; PEP_carboxykinase_GTP. DR InterPro; IPR035077; PEP_carboxykinase_GTP_C. DR InterPro; IPR035078; PEP_carboxykinase_GTP_N. DR InterPro; IPR008210; PEP_carboxykinase_N. DR PANTHER; PTHR11561; PHOSPHOENOLPYRUVATE CARBOXYKINASE; 1. DR PANTHER; PTHR11561:SF0; PHOSPHOENOLPYRUVATE CARBOXYKINASE, CYTOSOLIC [GTP]; 1. DR Pfam; PF00821; PEPCK_GTP; 1. DR Pfam; PF17297; PEPCK_N; 1. DR PIRSF; PIRSF001348; PEP_carboxykinase_GTP; 1. DR SUPFAM; SSF68923; PEP carboxykinase N-terminal domain; 1. DR SUPFAM; SSF53795; PEP carboxykinase-like; 1. DR PROSITE; PS00505; PEPCK_GTP; 1. PE 3: Inferred from homology; KW Decarboxylase {ECO:0000256|ARBA:ARBA00022793}; KW GTP-binding {ECO:0000256|ARBA:ARBA00023134}; KW Lyase {ECO:0000256|ARBA:ARBA00023239}; KW Manganese {ECO:0000256|ARBA:ARBA00023211}; KW Metal-binding {ECO:0000256|ARBA:ARBA00022723}; KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}; KW Reference proteome {ECO:0000313|Proteomes:UP000007062}. FT DOMAIN 52..278 FT /note="Phosphoenolpyruvate carboxykinase GTP-utilising N- FT terminal" FT /evidence="ECO:0000259|Pfam:PF17297" FT DOMAIN 283..646 FT /note="Phosphoenolpyruvate carboxykinase C-terminal P-loop" FT /evidence="ECO:0000259|Pfam:PF00821" SQ SEQUENCE 650 AA; 71702 MW; D60F1B25631EC417 CRC64; MPQLIEQYTP LPTTLGCSPK LKTLPKNLYN HLRGFPVVNG EVSLLSDKVR RFVEESAAMC QPDRIHIVDG SESESSTLLK TLHSQGTIKP LPKYDNCWLA RTNPADVARV ESKTFICTER PEQAIPTPKP GVNGALGNWI SPADYDRAIM SRFPGCMKGR TMFVVPFSMG PIASPLSKIG IEITDSAYVV ASMRIMTRMG AEVLDKLSDN SDFIRCLHSV GTPANGKIAV PSWPCDPERT IILHKPANNE IVSYGSGYGG NSLLGKKCFA LRIGSTIAQR EGWLAEHMLI LGITDPNGVK KYIAAAFPSA CGKTNLAMMN PTLPGYKIEC VGDDIAWMKF DSKGQLRAIN PENGFFGVAP GTSSETNPNA METIYKNTIF TNVASTSDGG VFWEGMEKEV SSDVEITDWL GNPWKLGESK TPAAHPNSRF CAPAGQCPII DPAWEDSEGV PISAILFGGR RPQGVPLVYE ANSWSHGVFV GSSMRSESTA AAEHKAKVIM NDPFAMRPFF GYNFGDYLKH WLSMEQRASA AGGHAPKIFH VNWFRKDANG KFLWPGFGEN SRVLEWILHR IDDADCYRDT PIGRVPTEGS LNLDGLSSPV NERELFSIPK DFWLREVEEV KQYYDNQLPQ DLPAEIASEL EQLKSRIEKM //
ID Q7Q9A8_ANOGA Unreviewed; 649 AA. AC Q7Q9A8; DT 15-DEC-2003, integrated into UniProtKB/TrEMBL. DT 09-JAN-2007, sequence version 3. DT 24-JAN-2024, entry version 120. DE RecName: Full=phosphoenolpyruvate carboxykinase (GTP) {ECO:0000256|ARBA:ARBA00012306}; DE EC=4.1.1.32 {ECO:0000256|ARBA:ARBA00012306}; GN Name=1275028 {ECO:0000313|EnsemblMetazoa:AGAP003350-PA}; GN ORFNames=AgaP_AGAP003350 {ECO:0000313|EMBL:EAA09667.3}; OS Anopheles gambiae (African malaria mosquito). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae; OC Anophelinae; Anopheles. OX NCBI_TaxID=7165 {ECO:0000313|EMBL:EAA09667.3}; RN [1] {ECO:0000313|EMBL:EAA09667.3, ECO:0000313|Proteomes:UP000007062} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=PEST {ECO:0000313|EMBL:EAA09667.3, RC ECO:0000313|Proteomes:UP000007062}; RX PubMed=12364791; DOI=10.1126/science.1076181; RA Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R., RA Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R., RA Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z., RA Kraft C.L., Abril J.F., Anthouard V., Arensburger P., Atkinson P.W., RA Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C., RA Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K., RA Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V., RA Dana A., Delcher A., Dew I., Evans C.A., Flanigan M., RA Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R., RA Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J., RA Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I., RA Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A., RA McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D., RA O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H., RA Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J., RA Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B., RA Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M., RA Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I., RA Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J., RA Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M., RA Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C., RA Collins F.H., Hoffman S.L.; RT "The genome sequence of the malaria mosquito Anopheles gambiae."; RL Science 298:129-149(2002). RN [2] {ECO:0000313|EMBL:EAA09667.3} RP NUCLEOTIDE SEQUENCE. RC STRAIN=PEST {ECO:0000313|EMBL:EAA09667.3}; RG The Anopheles Genome Sequencing Consortium; RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|EMBL:EAA09667.3} RP NUCLEOTIDE SEQUENCE. RC STRAIN=PEST {ECO:0000313|EMBL:EAA09667.3}; RX PubMed=14747013; DOI=10.1016/j.pt.2003.11.003; RA Mongin E., Louis C., Holt R.A., Birney E., Collins F.H.; RT "The Anopheles gambiae genome: an update."; RL Trends Parasitol. 20:49-52(2004). RN [4] {ECO:0000313|EMBL:EAA09667.3} RP NUCLEOTIDE SEQUENCE. RC STRAIN=PEST {ECO:0000313|EMBL:EAA09667.3}; RX PubMed=17210077; DOI=10.1186/gb-2007-8-1-r5; RA Sharakhova M.V., Hammond M.P., Lobo N.F., Krzywinski J., Unger M.F., RA Hillenmeyer M.E., Bruggner R.V., Birney E., Collins F.H.; RT "Update of the Anopheles gambiae PEST genome assembly."; RL Genome Biol. 8:R5.1-R5.13(2007). RN [5] {ECO:0000313|EMBL:EAA09667.3} RP NUCLEOTIDE SEQUENCE. RC STRAIN=PEST {ECO:0000313|EMBL:EAA09667.3}; RG VectorBase; RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases. RN [6] {ECO:0000313|EnsemblMetazoa:AGAP003350-PA} RP IDENTIFICATION. RC STRAIN=PEST {ECO:0000313|EnsemblMetazoa:AGAP003350-PA}; RG EnsemblMetazoa; RL Submitted (MAY-2020) to UniProtKB. CC -!- COFACTOR: CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035; CC Evidence={ECO:0000256|ARBA:ARBA00001936}; CC -!- SIMILARITY: Belongs to the phosphoenolpyruvate carboxykinase [GTP] CC family. {ECO:0000256|ARBA:ARBA00005796}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AAAB01008904; EAA09667.3; -; Genomic_DNA. DR RefSeq; XP_314250.3; XM_314250.4. DR AlphaFoldDB; Q7Q9A8; -. DR EnsemblMetazoa; AGAP003350-RA; AGAP003350-PA; AGAP003350. DR GeneID; 1275028; -. DR VEuPathDB; VectorBase:AGAP003350; -. DR OrthoDB; 5471652at2759; -. DR Proteomes; UP000007062; Chromosome 2R. DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0004613; F:phosphoenolpyruvate carboxykinase (GTP) activity; IEA:UniProtKB-EC. DR GO; GO:0006094; P:gluconeogenesis; IEA:InterPro. DR CDD; cd00819; PEPCK_GTP; 1. DR Gene3D; 3.90.228.20; -; 1. DR Gene3D; 3.40.449.10; Phosphoenolpyruvate Carboxykinase, domain 1; 1. DR Gene3D; 2.170.8.10; Phosphoenolpyruvate Carboxykinase, domain 2; 1. DR HAMAP; MF_00452; PEPCK_GTP; 1. DR InterPro; IPR018091; PEP_carboxykin_GTP_CS. DR InterPro; IPR013035; PEP_carboxykinase_C. DR InterPro; IPR008209; PEP_carboxykinase_GTP. DR InterPro; IPR035077; PEP_carboxykinase_GTP_C. DR InterPro; IPR035078; PEP_carboxykinase_GTP_N. DR InterPro; IPR008210; PEP_carboxykinase_N. DR PANTHER; PTHR11561; PHOSPHOENOLPYRUVATE CARBOXYKINASE; 1. DR PANTHER; PTHR11561:SF0; PHOSPHOENOLPYRUVATE CARBOXYKINASE, CYTOSOLIC [GTP]; 1. DR Pfam; PF00821; PEPCK_GTP; 1. DR Pfam; PF17297; PEPCK_N; 1. DR PIRSF; PIRSF001348; PEP_carboxykinase_GTP; 1. DR SUPFAM; SSF68923; PEP carboxykinase N-terminal domain; 1. DR SUPFAM; SSF53795; PEP carboxykinase-like; 1. DR PROSITE; PS00505; PEPCK_GTP; 1. PE 3: Inferred from homology; KW Decarboxylase {ECO:0000256|ARBA:ARBA00022793}; KW GTP-binding {ECO:0000256|ARBA:ARBA00023134}; KW Lyase {ECO:0000256|ARBA:ARBA00023239}; KW Manganese {ECO:0000256|ARBA:ARBA00023211}; KW Metal-binding {ECO:0000256|ARBA:ARBA00022723}; KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}; KW Reference proteome {ECO:0000313|Proteomes:UP000007062}. FT DOMAIN 51..277 FT /note="Phosphoenolpyruvate carboxykinase GTP-utilising N- FT terminal" FT /evidence="ECO:0000259|Pfam:PF17297" FT DOMAIN 282..645 FT /note="Phosphoenolpyruvate carboxykinase C-terminal P-loop" FT /evidence="ECO:0000259|Pfam:PF00821" SQ SEQUENCE 649 AA; 71573 MW; F8D97B124A1B1AF1 CRC64; MVKLFALLRL PTTLGCSPKL KTLPKNLYNH LRGFPVVNGE VSLLSDKVRR FVEESAAMCQ PDRIHIVDGS ESESSTLLKT LHSQGTIKPL PKYDNCWLAR TNPADVARVE SKTFICTERP EQAIPTPKPG VNGALGNWIS PADYDRAIMS RFPGCMKGRT MFVVPFSMGP IASPLSKIGI EITDSAYVVA SMRIMTRMGA EVLDKLSDNS DFIRCLHSVG TPANGKIAVP SWPCDPERTI ILHKPANNEI VSYGSGYGGN SLLGKKCFAL RIGSTIAQRE GWLAEHMLIL GITDPNGVKK YIAAAFPSAC GKTNLAMMNP TLPGYKIECV GDDIAWMKFD SKGQLRAINP ENGFFGVAPG TSSETNPNAM ETIYKNTIFT NVASTSDGGV FWEGMEKEVS SDVEITDWLG NPWKLGESKT PAAHPNSRFC APAGQCPIID PAWEDSEGVP ISAILFGGRR PQGVPLVYEA NSWSHGVFVG SSMRSESTAA AEHKAKVIMN DPFAMRPFFG YNFGDYLKHW LSMEQRASAA GGHAPKIFHV NWFRKDANGK FLWPGFGENS RVLEWILHRI DDADCYRDTP IGRVPTEGSL NLDGLSSPVN ERELFSIPKD FWLREVEEVK QYYDNQLPQD LPAEIASELE QLKSRIEKM //