ID F5Z227_MYCSD Unreviewed; 381 AA.
AC F5Z227;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 27-JUL-2011, sequence version 1.
DT 01-MAY-2013, entry version 14.
DE RecName: Full=Acetate kinase;
DE EC=2.7.2.1;
DE AltName: Full=Acetokinase;
GN Name=ackA; OrderedLocusNames=JDM601_3027;
OS Mycobacterium sp. (strain JDM601).
OC Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC Corynebacterineae; Mycobacteriaceae; Mycobacterium.
OX NCBI_TaxID=875328;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JDM601;
RX PubMed=21685274; DOI=10.1128/JB.05291-11;
RA Zhang Z.Y., Sun Z.Q., Wang Z.L., Wen Z.L., Sun Q.W., Zhu Z.Q.,
RA Song Y.Z., Zhao J.W., Wang H.H., Zhang S.L., Guo X.K.;
RT "Complete gnome sequence of a novel clinical isolate, the
RT nontuberculous Mycobacterium strain JDM601.";
RL J. Bacteriol. 193:4300-4301(2011).
CC -!- FUNCTION: Catalyzes the formation of acetyl phosphate from acetate
CC and ATP. Can also catalyze the reverse reaction (By similarity).
CC -!- CATALYTIC ACTIVITY: ATP + acetate = ADP + acetyl phosphate.
CC -!- COFACTOR: Mg(2+). Can also accept Mn(2+) (By similarity).
CC -!- PATHWAY: Metabolic intermediate biosynthesis; acetyl-CoA
CC biosynthesis; acetyl-CoA from acetate: step 1/2.
CC -!- SUBUNIT: Homodimer (By similarity).
CC -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC -!- SIMILARITY: Belongs to the acetokinase family.
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DR EMBL; CP002329; AEF37027.1; -; Genomic_DNA.
DR RefSeq; YP_004524281.1; NC_015576.1.
DR EnsemblBacteria; AEF37027; AEF37027; JDM601_3027.
DR GeneID; 10685060; -.
DR KEGG; mjd:JDM601_3027; -.
DR KO; K00925; -.
DR BioCyc; MSP875328:GHLX-3028-MONOMER; -.
DR UniPathway; UPA00340; UER00458.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008776; F:acetate kinase activity; IEA:HAMAP.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0006085; P:acetyl-CoA biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0006082; P:organic acid metabolic process; IEA:InterPro.
DR HAMAP; MF_00020; Acetate_kinase; 1; -.
DR InterPro; IPR004372; Ac/Proprionate_kinase.
DR InterPro; IPR000890; Aliphatic_acid_kin_short-chain.
DR InterPro; IPR023865; Aliphatic_acid_kinase_CS.
DR PANTHER; PTHR21060; PTHR21060; 1.
DR Pfam; PF00871; Acetate_kinase; 1.
DR PIRSF; PIRSF000722; Acetate_prop_kin; 1.
DR PRINTS; PR00471; ACETATEKNASE.
DR TIGRFAMs; TIGR00016; ackA; 1.
DR PROSITE; PS01075; ACETATE_KINASE_1; 1.
DR PROSITE; PS01076; ACETATE_KINASE_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; Complete proteome; Cytoplasm; Kinase; Magnesium;
KW Metal-binding; Nucleotide-binding; Transferase.
FT NP_BIND 194 198 ATP (By similarity).
FT NP_BIND 268 270 ATP (By similarity).
FT NP_BIND 316 320 ATP (By similarity).
FT ACT_SITE 134 134 Proton donor/acceptor (By similarity).
FT METAL 13 13 Magnesium (By similarity).
FT METAL 369 369 Magnesium (By similarity).
FT BINDING 20 20 ATP (By similarity).
FT BINDING 77 77 Substrate (By similarity).
FT SITE 166 166 Transition state stabilizer (By
FT similarity).
FT SITE 227 227 Transition state stabilizer (By
FT similarity).
SQ SEQUENCE 381 AA; 39876 MW; D9B32C76F4D1A490 CRC64;
MSAVSAGVVL VLNSGSSSIK FRLIDPVAGT AVVSGLVEQI GEPDSAVADH AAGLRLIHQR
LADSGVDLGE VRAVGHRVVH GGTRFHAPTL ITDAVVAEVS RLAELAPLHN PANVIGIEVA
RADFPDVPHV AVFDTGFFHS LPAAAAAYAI DREVASQYGI RRYGFHGTSH EYVSREAALL
LGREPAEVNT IVLHLGNGAS ASAVRGGVAV ETSMGLTPLE GLVMGTRCGD IDPGVLFHLN
RTAGLGVDKL DELLNRRSGL KGLSGVNDFR ELLQQVSHGS SAATLAYDVY IHRLRKYVGA
YLAVLGRVDA IAFTAGVGEN VAAVREDALA GLDGLGIVVD PQRNRGGNGA RIISAEHSRS
TVLVVPTNEE LAIARAAWQF V
//
