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Database: UniProt/TrEMBL
Entry: F5ZR19_SALTU
LinkDB: F5ZR19_SALTU
Original site: F5ZR19_SALTU 
ID   F5ZR19_SALTU            Unreviewed;       283 AA.
AC   F5ZR19;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   09-JUL-2014, entry version 23.
DE   RecName: Full=4-diphosphocytidyl-2-C-methyl-D-erythritol kinase;
DE            Short=CMK;
DE            EC=2.7.1.148;
DE   AltName: Full=4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase;
GN   Name=ipk; Synonyms=ispE; OrderedLocusNames=STMUK_1751;
OS   Salmonella typhimurium (strain ATCC 68169 / UK-1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=990282;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 68169 / UK-1;
RX   PubMed=21622747; DOI=10.1128/JB.05224-11;
RA   Luo Y., Kong Q., Yang J., Golden G., Wanda S.Y., Jensen R.V.,
RA   Ernst P.B., Curtiss R.III.;
RT   "Complete genome sequence of the universal killer Salmonella enterica
RT   Serovar Typhimurium UK-1 (ATCC 68169).";
RL   J. Bacteriol. 193:4035-4036(2011).
CC   -!- FUNCTION: Catalyzes the phosphorylation of the position 2 hydroxy
CC       group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By
CC       similarity).
CC   -!- CATALYTIC ACTIVITY: ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-
CC       erythritol = ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-
CC       D-erythritol.
CC   -!- PATHWAY: Isoprenoid biosynthesis; isopentenyl diphosphate
CC       biosynthesis via DXP pathway; isopentenyl diphosphate from 1-
CC       deoxy-D-xylulose 5-phosphate: step 3/6.
CC   -!- SUBUNIT: Homodimer (By similarity).
CC   -!- SIMILARITY: Belongs to the GHMP kinase family. IspE subfamily.
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DR   EMBL; CP002614; AEF07649.1; -; Genomic_DNA.
DR   RefSeq; YP_005252283.1; NC_016863.1.
DR   ProteinModelPortal; F5ZR19; -.
DR   SMR; F5ZR19; 1-283.
DR   PRIDE; F5ZR19; -.
DR   EnsemblBacteria; AEF07649; AEF07649; STMUK_1751.
DR   BioCyc; SENT990282:GHYP-1751-MONOMER; -.
DR   UniPathway; UPA00056; UER00094.
DR   GO; GO:0050515; F:4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0019288; P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway; IEA:UniProtKB-UniPathway.
DR   GO; GO:0016114; P:terpenoid biosynthetic process; IEA:UniProtKB-HAMAP.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.70.890; -; 1.
DR   HAMAP; MF_00061; IspE; 1.
DR   InterPro; IPR013750; GHMP_kinase_C_dom.
DR   InterPro; IPR006204; GHMP_kinase_N_dom.
DR   InterPro; IPR004424; IspE.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR20861:SF2; PTHR20861:SF2; 1.
DR   Pfam; PF08544; GHMP_kinases_C; 1.
DR   Pfam; PF00288; GHMP_kinases_N; 1.
DR   PIRSF; PIRSF010376; IspE; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55060; SSF55060; 1.
DR   TIGRFAMs; TIGR00154; ispE; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Isoprene biosynthesis; Kinase;
KW   Nucleotide-binding; Transferase.
FT   NP_BIND      99    109       ATP (By similarity){EA3}.
FT   ACT_SITE     10     10       By similarity{EA3}.
FT   ACT_SITE    141    141       By similarity{EA3}.
SQ   SEQUENCE   283 AA;  30883 MW;  E33EAF956D12A5BD CRC64;
     MMTHWPSPAK LNLFLYITGQ RADGYHTLQT LFQFLDYGDT LHIEPRHDGE IHLLTPVNGV
     ENEDNLIVRA ARLLMKVASE SGRLPAGSGA DISIEKRLPM GGGLGGGSSN AATVLVALNH
     LWQCGLSIDE LATLGLTLGA DVPVFVRGHA AFAEGVGEIL TPVNPPEKWY LVAHPGVSIP
     TPVIFKDPQL PRNTPKRSID TLLKCEFSND CEVIARKRFR EVDAALSWLL EYAPSRLTGT
     GACVFAEFDT ESCARQVLEQ APEWLNAFVA KGVNLSPLHR ELL
//
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