ID F5ZR19_SALTU Unreviewed; 283 AA.
AC F5ZR19;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 27-JUL-2011, sequence version 1.
DT 29-MAY-2013, entry version 16.
DE RecName: Full=4-diphosphocytidyl-2-C-methyl-D-erythritol kinase;
DE Short=CMK;
DE EC=2.7.1.148;
DE AltName: Full=4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase;
GN Name=ipk; Synonyms=ispE; OrderedLocusNames=STMUK_1751;
OS Salmonella typhimurium (strain ATCC 68169 / UK-1).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=990282;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 68169 / UK-1;
RX PubMed=21622747; DOI=10.1128/JB.05224-11;
RA Luo Y., Kong Q., Yang J., Golden G., Wanda S.Y., Jensen R.V.,
RA Ernst P.B., Curtiss R.III.;
RT "Complete genome sequence of the universal killer Salmonella enterica
RT Serovar Typhimurium UK-1 (ATCC 68169).";
RL J. Bacteriol. 193:4035-4036(2011).
CC -!- FUNCTION: Catalyzes the phosphorylation of the position 2 hydroxy
CC group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By
CC similarity).
CC -!- CATALYTIC ACTIVITY: ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-
CC erythritol = ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-
CC D-erythritol.
CC -!- PATHWAY: Isoprenoid biosynthesis; isopentenyl diphosphate
CC biosynthesis via DXP pathway; isopentenyl diphosphate from 1-
CC deoxy-D-xylulose 5-phosphate: step 3/6.
CC -!- SUBUNIT: Homodimer (By similarity).
CC -!- SIMILARITY: Belongs to the GHMP kinase family. IspE subfamily.
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DR EMBL; CP002614; AEF07649.1; -; Genomic_DNA.
DR RefSeq; YP_005252283.1; NC_016863.1.
DR ProteinModelPortal; F5ZR19; -.
DR SMR; F5ZR19; 1-283.
DR PRIDE; F5ZR19; -.
DR EnsemblBacteria; AEF07649; AEF07649; STMUK_1751.
DR GeneID; 11835889; -.
DR KEGG; sej:STMUK_1751; -.
DR KO; K00919; -.
DR BioCyc; SENT990282:GHYP-1751-MONOMER; -.
DR UniPathway; UPA00056; UER00094.
DR GO; GO:0050515; F:4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity; IEA:HAMAP.
DR GO; GO:0005524; F:ATP binding; IEA:HAMAP.
DR GO; GO:0019288; P:isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway; IEA:UniProtKB-UniPathway.
DR GO; GO:0016114; P:terpenoid biosynthetic process; IEA:HAMAP.
DR Gene3D; 3.30.230.10; -; 1.
DR HAMAP; MF_00061; IspE; 1; -.
DR InterPro; IPR013750; GHMP_kinase_C_dom.
DR InterPro; IPR006204; GHMP_kinase_N_dom.
DR InterPro; IPR004424; IspE.
DR InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR PANTHER; PTHR20861:SF2; PTHR20861:SF2; 1.
DR Pfam; PF08544; GHMP_kinases_C; 1.
DR Pfam; PF00288; GHMP_kinases_N; 1.
DR PIRSF; PIRSF010376; IspE; 1.
DR SUPFAM; SSF54211; Ribosomal_S5_D2-typ_fold; 1.
DR TIGRFAMs; TIGR00154; ispE; 1.
PE 3: Inferred from homology;
KW ATP-binding; Complete proteome; Isoprene biosynthesis; Kinase;
KW Nucleotide-binding; Transferase.
FT NP_BIND 99 109 ATP (By similarity).
FT ACT_SITE 10 10 By similarity.
FT ACT_SITE 141 141 By similarity.
SQ SEQUENCE 283 AA; 30883 MW; E33EAF956D12A5BD CRC64;
MMTHWPSPAK LNLFLYITGQ RADGYHTLQT LFQFLDYGDT LHIEPRHDGE IHLLTPVNGV
ENEDNLIVRA ARLLMKVASE SGRLPAGSGA DISIEKRLPM GGGLGGGSSN AATVLVALNH
LWQCGLSIDE LATLGLTLGA DVPVFVRGHA AFAEGVGEIL TPVNPPEKWY LVAHPGVSIP
TPVIFKDPQL PRNTPKRSID TLLKCEFSND CEVIARKRFR EVDAALSWLL EYAPSRLTGT
GACVFAEFDT ESCARQVLEQ APEWLNAFVA KGVNLSPLHR ELL
//
