ID F5ZUC2_SALTU Unreviewed; 355 AA.
AC F5ZUC2;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 27-JUL-2011, sequence version 1.
DT 29-MAY-2013, entry version 15.
DE RecName: Full=UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase;
DE EC=2.4.1.227;
DE AltName: Full=Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase;
GN Name=murG; OrderedLocusNames=STMUK_0130;
OS Salmonella typhimurium (strain ATCC 68169 / UK-1).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=990282;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 68169 / UK-1;
RX PubMed=21622747; DOI=10.1128/JB.05224-11;
RA Luo Y., Kong Q., Yang J., Golden G., Wanda S.Y., Jensen R.V.,
RA Ernst P.B., Curtiss R.III.;
RT "Complete genome sequence of the universal killer Salmonella enterica
RT Serovar Typhimurium UK-1 (ATCC 68169).";
RL J. Bacteriol. 193:4035-4036(2011).
CC -!- FUNCTION: Cell wall formation. Catalyzes the transfer of a GlcNAc
CC subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid
CC intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-
CC (pentapeptide)GlcNAc (lipid intermediate II) (By similarity).
CC -!- CATALYTIC ACTIVITY: UDP-N-acetylglucosamine + Mur2Ac(oyl-L-Ala-
CC gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol = UDP +
CC GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-
CC diphosphoundecaprenol.
CC -!- PATHWAY: Cell wall biogenesis; peptidoglycan biosynthesis.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane; Peripheral membrane
CC protein (By similarity).
CC -!- SIMILARITY: Belongs to the glycosyltransferase 28 family. MurG
CC subfamily.
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DR EMBL; CP002614; AEF06064.1; -; Genomic_DNA.
DR RefSeq; YP_005250698.1; NC_016863.1.
DR ProteinModelPortal; F5ZUC2; -.
DR SMR; F5ZUC2; 6-354.
DR PRIDE; F5ZUC2; -.
DR EnsemblBacteria; AEF06064; AEF06064; STMUK_0130.
DR GeneID; 11834268; -.
DR KEGG; sej:STMUK_0130; -.
DR KO; K02563; -.
DR BioCyc; SENT990282:GHYP-130-MONOMER; -.
DR UniPathway; UPA00219; -.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0051991; F:UDP-N-acetyl-D-glucosamine:N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol 4-beta-N-acetylglucosaminlytransferase activity; IEA:EC.
DR GO; GO:0050511; F:undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity; IEA:HAMAP.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0030259; P:lipid glycosylation; IEA:HAMAP.
DR GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:HAMAP.
DR GO; GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW.
DR GO; GO:0019277; P:UDP-N-acetylgalactosamine biosynthetic process; IEA:InterPro.
DR HAMAP; MF_00033; MurG; 1; -.
DR InterPro; IPR006009; GlcNAc_MurG.
DR InterPro; IPR004276; Glyco_trans_28.
DR InterPro; IPR007235; Glyco_trans_28_C.
DR PANTHER; PTHR21015:SF22; PTHR21015:SF22; 1.
DR Pfam; PF04101; Glyco_tran_28_C; 1.
DR Pfam; PF03033; Glyco_transf_28; 1.
DR TIGRFAMs; TIGR01133; murG; 1.
PE 3: Inferred from homology;
KW Cell cycle; Cell division; Cell inner membrane; Cell membrane;
KW Cell shape; Cell wall biogenesis/degradation; Complete proteome;
KW Glycosyltransferase; Membrane; Peptidoglycan synthesis; Transferase.
SQ SEQUENCE 355 AA; 37863 MW; DE338E433C134809 CRC64;
MSGQPKRLMV MAGGTGGHVF PGLAVAHHLM AQGWQVRWLG TADRMEADLV PKHGIDIDFI
RISGLRGKGV KALLAAPLRI FNAWRQARAI MKRFKPDVVL GMGGYVSGPG GLAAWSLGIP
VVLHEQNGIA GLTNQWLAKI ATTVMQAFPG AFPNAEVVGN PVRTDVLALP LPQVRLAGRD
GPIRVLVVGG SQGARVLNQT MPQVAARLGD TVTIWHQSGK GAQLTVEQAY AGAGQPQHKV
TEFIDDMAAA YAWADVVVCR SGALTVSEIA AAGLPAIFVP FQHKDRQQYW NALPLENAGA
AKIFEQPQFT VEAVADTLAG WSREALLTMA ERARAVSIPD ATERVASEVS RVART
//
