ID F6E0A0_SINMK Unreviewed; 234 AA.
AC F6E0A0;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 27-JUL-2011, sequence version 1.
DT 29-MAY-2013, entry version 11.
DE RecName: Full=Thymidylate kinase;
DE EC=2.7.4.9;
DE AltName: Full=dTMP kinase;
GN Name=tmk; OrderedLocusNames=Sinme_1503;
OS Sinorhizobium meliloti (strain AK83).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC Rhizobiaceae; Sinorhizobium/Ensifer group; Sinorhizobium.
OX NCBI_TaxID=693982;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AK83;
RX PubMed=21569405; DOI=10.1186/1471-2164-12-235;
RG US DOE Joint Genome Institute;
RA Galardini M., Mengoni A., Brilli M., Pini F., Fioravanti A., Lucas S.,
RA Lapidus A., Cheng J.F., Goodwin L., Pitluck S., Land M., Hauser L.,
RA Woyke T., Mikhailova N., Ivanova N., Daligault H., Bruce D.,
RA Detter C., Tapia R., Han C., Teshima H., Mocali S., Bazzicalupo M.,
RA Biondi E.G.;
RT "Exploring the symbiotic pangenome of the nitrogen-fixing bacterium
RT Sinorhizobium meliloti.";
RL BMC Genomics 12:235-235(2011).
CC -!- FUNCTION: Phosphorylation of dTMP to form dTDP in both de novo and
CC salvage pathways of dTTP synthesis (By similarity).
CC -!- CATALYTIC ACTIVITY: ATP + dTMP = ADP + dTDP.
CC -!- SIMILARITY: Belongs to the thymidylate kinase family.
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DR EMBL; CP002781; AEG53244.1; -; Genomic_DNA.
DR RefSeq; YP_004548858.1; NC_015590.1.
DR EnsemblBacteria; AEG53244; AEG53244; Sinme_1503.
DR GeneID; 10726082; -.
DR KEGG; smk:Sinme_1503; -.
DR KO; K00943; -.
DR BioCyc; SMEL693982:GJDT-1524-MONOMER; -.
DR GO; GO:0005524; F:ATP binding; IEA:HAMAP.
DR GO; GO:0004798; F:thymidylate kinase activity; IEA:HAMAP.
DR GO; GO:0006233; P:dTDP biosynthetic process; IEA:InterPro.
DR GO; GO:0006235; P:dTTP biosynthetic process; IEA:HAMAP.
DR HAMAP; MF_00165; Thymidylate_kinase; 1; -.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR018095; Thymidylate_kin_CS.
DR InterPro; IPR018094; Thymidylate_kinase.
DR PANTHER; PTHR10344; PTHR10344; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR00041; DTMP_kinase; 1.
DR PROSITE; PS01331; THYMIDYLATE_KINASE; 1.
PE 3: Inferred from homology;
KW ATP-binding; Complete proteome; Kinase; Nucleotide biosynthesis;
KW Nucleotide-binding; Transferase.
FT NP_BIND 21 28 ATP (By similarity).
SQ SEQUENCE 234 AA; 25211 MW; B49282400F90C2C4 CRC64;
MHADPGIEVS LAKGFFITFE GGEGAGKSTQ MRLLAEALSA RGYRVLTTRE PGGSVGAEAV
RHVLLSGAAE SFGVRMEAIL FAAARSDHVE EVIRPALEQG TIVLCDRFMD SSRVYQGVTG
NLEPAFVETL ERVAVNGVIP DCTIIFDLPA SVGLERARRR AANDSPDRFE KEQLETHEKR
REAFLDIAAA DPERCRVVDA NRPPTAIAAE VLSLVEALLP LEGKPQPSNA EATS
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