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Database: UniProt/TrEMBL
Entry: F6E0A0_SINMK
LinkDB: F6E0A0_SINMK
Original site: F6E0A0_SINMK 
ID   F6E0A0_SINMK            Unreviewed;       234 AA.
AC   F6E0A0;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   29-OCT-2014, entry version 18.
DE   RecName: Full=Thymidylate kinase {ECO:0000256|HAMAP-Rule:MF_00165};
DE            EC=2.7.4.9 {ECO:0000256|HAMAP-Rule:MF_00165};
DE   AltName: Full=dTMP kinase {ECO:0000256|HAMAP-Rule:MF_00165};
GN   Name=tmk {ECO:0000256|HAMAP-Rule:MF_00165};
GN   OrderedLocusNames=Sinme_1503 {ECO:0000313|EMBL:AEG53244.1};
OS   Sinorhizobium meliloti (strain AK83).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Rhizobiaceae; Sinorhizobium/Ensifer group; Sinorhizobium.
OX   NCBI_TaxID=693982 {ECO:0000313|EMBL:AEG53244.1, ECO:0000313|Proteomes:UP000008705};
RN   [1] {ECO:0000313|Proteomes:UP000008705}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AK83 {ECO:0000313|Proteomes:UP000008705};
RX   PubMed=21569405; DOI=10.1186/1471-2164-12-235;
RG   US DOE Joint Genome Institute;
RA   Galardini M., Mengoni A., Brilli M., Pini F., Fioravanti A., Lucas S.,
RA   Lapidus A., Cheng J.F., Goodwin L., Pitluck S., Land M., Hauser L.,
RA   Woyke T., Mikhailova N., Ivanova N., Daligault H., Bruce D.,
RA   Detter C., Tapia R., Han C., Teshima H., Mocali S., Bazzicalupo M.,
RA   Biondi E.G.;
RT   "Exploring the symbiotic pangenome of the nitrogen-fixing bacterium
RT   Sinorhizobium meliloti.";
RL   BMC Genomics 12:235-235(2011).
CC   -!- FUNCTION: Phosphorylation of dTMP to form dTDP in both de novo and
CC       salvage pathways of dTTP synthesis. {ECO:0000256|HAMAP-
CC       Rule:MF_00165}.
CC   -!- CATALYTIC ACTIVITY: ATP + dTMP = ADP + dTDP. {ECO:0000256|HAMAP-
CC       Rule:MF_00165, ECO:0000256|SAAS:SAAS00031904}.
CC   -!- SIMILARITY: Belongs to the thymidylate kinase family.
CC       {ECO:0000256|HAMAP-Rule:MF_00165}.
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DR   EMBL; CP002781; AEG53244.1; -; Genomic_DNA.
DR   RefSeq; YP_004548858.1; NC_015590.1.
DR   EnsemblBacteria; AEG53244; AEG53244; Sinme_1503.
DR   GeneID; 10726082; -.
DR   KEGG; smk:Sinme_1503; -.
DR   KO; K00943; -.
DR   OMA; EPGGCPI; -.
DR   BioCyc; SMEL693982:GJDT-1524-MONOMER; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0004798; F:thymidylate kinase activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006233; P:dTDP biosynthetic process; IEA:InterPro.
DR   GO; GO:0006235; P:dTTP biosynthetic process; IEA:UniProtKB-HAMAP.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00165; Thymidylate_kinase; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR018095; Thymidylate_kin_CS.
DR   InterPro; IPR018094; Thymidylate_kinase.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00041; DTMP_kinase; 1.
DR   PROSITE; PS01331; THYMIDYLATE_KINASE; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00165,
KW   ECO:0000256|SAAS:SAAS00031914};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008705};
KW   Kinase {ECO:0000256|HAMAP-Rule:MF_00165,
KW   ECO:0000256|SAAS:SAAS00031912};
KW   Nucleotide biosynthesis {ECO:0000256|HAMAP-Rule:MF_00165,
KW   ECO:0000256|SAAS:SAAS00031908};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00165,
KW   ECO:0000256|SAAS:SAAS00031897};
KW   Transferase {ECO:0000256|HAMAP-Rule:MF_00165,
KW   ECO:0000256|SAAS:SAAS00031919}.
FT   NP_BIND      21     28       ATP. {ECO:0000256|HAMAP-Rule:MF_00165}.
SQ   SEQUENCE   234 AA;  25211 MW;  B49282400F90C2C4 CRC64;
     MHADPGIEVS LAKGFFITFE GGEGAGKSTQ MRLLAEALSA RGYRVLTTRE PGGSVGAEAV
     RHVLLSGAAE SFGVRMEAIL FAAARSDHVE EVIRPALEQG TIVLCDRFMD SSRVYQGVTG
     NLEPAFVETL ERVAVNGVIP DCTIIFDLPA SVGLERARRR AANDSPDRFE KEQLETHEKR
     REAFLDIAAA DPERCRVVDA NRPPTAIAAE VLSLVEALLP LEGKPQPSNA EATS
//
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