ID   F6FWT7_ISOV2            Unreviewed;       540 AA.
AC   F6FWT7;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   27-MAR-2024, entry version 49.
DE   SubName: Full=Succinate-semialdehyde dehydrogenase (NAD(P)(+)) {ECO:0000313|EMBL:AEG43509.1};
DE            EC=1.2.1.16 {ECO:0000313|EMBL:AEG43509.1};
GN   OrderedLocusNames=Isova_0723 {ECO:0000313|EMBL:AEG43509.1};
OS   Isoptericola variabilis (strain 225).
OC   Bacteria; Actinomycetota; Actinomycetes; Micrococcales;
OC   Promicromonosporaceae; Isoptericola.
OX   NCBI_TaxID=743718 {ECO:0000313|Proteomes:UP000009236};
RN   [1] {ECO:0000313|EMBL:AEG43509.1, ECO:0000313|Proteomes:UP000009236}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=225 {ECO:0000313|Proteomes:UP000009236};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA   Peters L., Mikhailova N., Zeytun A., Han C., Tapia R., Land M., Hauser L.,
RA   Kyrpides N., Ivanova N., Pagani I., Siebers A., Allgaier M., Thelen M.,
RA   Hugenholtz P., Gladden J., Woyke T.;
RT   "Complete sequence of Isoptericola variabilis 225.";
RL   Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC       {ECO:0000256|RuleBase:RU003345}.
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DR   EMBL; CP002810; AEG43509.1; -; Genomic_DNA.
DR   RefSeq; WP_013837901.1; NC_015588.1.
DR   AlphaFoldDB; F6FWT7; -.
DR   STRING; 743718.Isova_0723; -.
DR   KEGG; iva:Isova_0723; -.
DR   eggNOG; COG1012; Bacteria.
DR   HOGENOM; CLU_005391_1_0_11; -.
DR   Proteomes; UP000009236; Chromosome.
DR   GO; GO:0036243; F:succinate-semialdehyde dehydrogenase (NADP+) activity; IEA:RHEA.
DR   InterPro; IPR016161; Ald_DH/histidinol_DH.
DR   InterPro; IPR016163; Ald_DH_C.
DR   InterPro; IPR029510; Ald_DH_CS_GLU.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR015590; Aldehyde_DH_dom.
DR   PANTHER; PTHR11699:SF211; ALDEHYDE DEHYDROGENASE FAMILY 16 MEMBER A1; 1.
DR   PANTHER; PTHR11699; ALDEHYDE DEHYDROGENASE-RELATED; 1.
DR   Pfam; PF00171; Aldedh; 1.
DR   SUPFAM; SSF53720; ALDH-like; 1.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000256|RuleBase:RU003345};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009236}.
FT   DOMAIN          45..500
FT                   /note="Aldehyde dehydrogenase"
FT                   /evidence="ECO:0000259|Pfam:PF00171"
FT   ACT_SITE        273
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU10007"
SQ   SEQUENCE   540 AA;  56570 MW;  B1C2032EC98B8F48 CRC64;
     MPSAHESDGA LDDLVDPELP TSTYVLEPEA VAPLVARVAT SHDAGTHRPV HPFTGAPLTS
     IPLSSAADVA AAVRRARVAQ RAWARVPVRE RAAVLDRLGA LVLERQSEIL DLVQMESGKA
     RRSAFEEVGD VAQVTRHYAV RGPRYLVDRR VPGMMPLVTG VRVHRRPVGV VGVVAAWNYP
     LTLALADAVP ALLAGDAVVL KPDPQTTLSA LWVAEQLEDA GLPADLFTVV AGGGEVGEAL
     VDHVDHVAFT GSTATGRAVA ARAGARLVGT TLELGGKNPL YVAADADLAS AVRGAVRACF
     SNAGQLCLSV ERLVLHEAVA DAFLERFVAA VKELRLGPGL DYSADVGSLV SQAQLDRVTR
     HVDDALARGA RALAGAVHRP DVGPYFYAPT VLDDVPADAL VATEETFGPV VTVTRVASDD
     DAVRVMNDTQ YGLNASIWSV DVARARRIAA RVEAGTVVIN DGYGSAWGSV AAPMGGVKAS
     GLGRRHGREA IEAVTEAQTV AVQRGARFGV ALETVYAAGG ETPSQVVTGA LRALRRLRLP
//