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Database: UniProt/TrEMBL
Entry: F6PW39_HORSE
LinkDB: F6PW39_HORSE
Original site: F6PW39_HORSE 
ID   F6PW39_HORSE            Unreviewed;       821 AA.
AC   F6PW39;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   30-AUG-2017, entry version 41.
DE   SubName: Full=Transglutaminase 1 {ECO:0000313|Ensembl:ENSECAP00000015519};
GN   Name=TGM1 {ECO:0000313|Ensembl:ENSECAP00000015519};
OS   Equus caballus (Horse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000015519, ECO:0000313|Proteomes:UP000002281};
RN   [1] {ECO:0000313|Ensembl:ENSECAP00000015519, ECO:0000313|Proteomes:UP000002281}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000015519,
RC   ECO:0000313|Proteomes:UP000002281};
RX   PubMed=19892987; DOI=10.1126/science.1178158;
RG   Broad Institute Genome Sequencing Platform;
RG   Broad Institute Whole Genome Assembly Team;
RA   Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA   Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H.,
RA   Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N.,
RA   Penedo M.C.T., Raison J.M., Sharpe T., Vogel J., Andersson L.,
RA   Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J.,
RA   Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J.,
RA   Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R.,
RA   Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F.,
RA   Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L.,
RA   Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M.,
RA   White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT   "Genome sequence, comparative analysis, and population genetics of the
RT   domestic horse.";
RL   Science 326:865-867(2009).
RN   [2] {ECO:0000313|Ensembl:ENSECAP00000015519}
RP   IDENTIFICATION.
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000015519};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSECAP00000015519}.
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DR   RefSeq; XP_001489215.1; XM_001489165.3.
DR   RefSeq; XP_014589564.1; XM_014734078.1.
DR   STRING; 9796.ENSECAP00000015519; -.
DR   PaxDb; F6PW39; -.
DR   PRIDE; F6PW39; -.
DR   Ensembl; ENSECAT00000018986; ENSECAP00000015519; ENSECAG00000017485.
DR   GeneID; 100054584; -.
DR   KEGG; ecb:100054584; -.
DR   CTD; 7051; -.
DR   eggNOG; ENOG410IFMV; Eukaryota.
DR   eggNOG; ENOG410XQEZ; LUCA.
DR   GeneTree; ENSGT00760000119108; -.
DR   InParanoid; F6PW39; -.
DR   KO; K05619; -.
DR   OMA; DDDWGPE; -.
DR   OrthoDB; EOG091G030K; -.
DR   TreeFam; TF324278; -.
DR   Proteomes; UP000002281; Chromosome 1.
DR   Bgee; ENSECAG00000017485; -.
DR   GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR   GO; GO:0031224; C:intrinsic component of membrane; IEA:Ensembl.
DR   GO; GO:0003810; F:protein-glutamine gamma-glutamyltransferase activity; IEA:Ensembl.
DR   GO; GO:0030216; P:keratinocyte differentiation; IEA:Ensembl.
DR   GO; GO:0018149; P:peptide cross-linking; IEA:Ensembl.
DR   GO; GO:0045787; P:positive regulation of cell cycle; IEA:Ensembl.
DR   GO; GO:0010838; P:positive regulation of keratinocyte proliferation; IEA:Ensembl.
DR   Gene3D; 2.60.40.10; -; 3.
DR   Gene3D; 3.90.260.10; -; 1.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR002931; Transglutaminase-like.
DR   InterPro; IPR023608; Transglutaminase_animal.
DR   InterPro; IPR013808; Transglutaminase_AS.
DR   InterPro; IPR008958; Transglutaminase_C.
DR   InterPro; IPR001102; Transglutaminase_N.
DR   Pfam; PF00927; Transglut_C; 2.
DR   Pfam; PF01841; Transglut_core; 1.
DR   Pfam; PF00868; Transglut_N; 1.
DR   PIRSF; PIRSF000459; TGM_EBP42; 1.
DR   SMART; SM00460; TGc; 1.
DR   SUPFAM; SSF49309; SSF49309; 2.
DR   SUPFAM; SSF81296; SSF81296; 1.
DR   PROSITE; PS00547; TRANSGLUTAMINASES; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002281};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT   DOMAIN      373    466       TGc. {ECO:0000259|SMART:SM00460}.
FT   ACT_SITE    381    381       {ECO:0000256|PIRSR:PIRSR000459-1}.
FT   ACT_SITE    440    440       {ECO:0000256|PIRSR:PIRSR000459-1}.
FT   ACT_SITE    463    463       {ECO:0000256|PIRSR:PIRSR000459-1}.
SQ   SEQUENCE   821 AA;  90387 MW;  7912B3E509F98BA7 CRC64;
     MTDGPRSDVG RWGGNAWQPP TTPSPEPEPE PEPDSRSRRG GRSFWARCCG CCSCRNDDDW
     GREPYRDRGS GSRGRGSRSG GRRPDSRGSD SRQPGSRGSG VNAAGDGTIR EGMLVVTGVD
     LLSSRSDQNR REHHTDEFEY DELIVRRGQP FHMVLLLSRP YESSDHIALE LLIGNNPEVG
     KGTHVIIPVG KGGSGGWKAQ VTKANGQNLN LRVHTSPNAI IGKFQFTVRT RTEAGEFQLP
     FDPHNEIYIL FNPWCPEDIV YVDHEDWRQE YVLNESGRIY YGTEAQIGER TWNYGQFDHG
     VLDACLYILD RRGMPYGGRG DPVNVSRVIS AMVNSLDDNG VLIGNWSGDY SRGTNPSAWV
     GSVEILLSYL RTGYSVPYGQ CWVFAGVTTT VLRCLGLATR TVTNFNSAHD TDTSLTMDIY
     FDENMKPLEH LNHDSVWNFH VWNDCWMKRP DLPSGFDGWQ VVDATPQETS SGIFCCGPCS
     VESIKNGLVY MKYDTPFIFA EVNSDKVYWQ RQDDGSFKIV YVEEKAIGTL IITKAIGSSM
     REDVTHIYKH PEGSEAERKA VETAAAHGSK PNVYANRDTA EDVAMQVEAQ DAVMGQDLTV
     SVVLTNRGSS RRTVKLHLYL SVTFYTGVTG SVFKESKKEV VLQPGASDRV AMPVAYTEYK
     PHLVDQGAML LNVSGHVKES GQVLAKQHTF RLRTPDLSLS LLGAAVVGQE CEVQIVFKNP
     LPVTLTNVVF RLEGSGLQRP KILNVGDIGG NETVTLRQTF VPVRPGPRQL IASLDSPQLS
     QVHGVIQVDV APAPGGGSFF SDARGNSRSG ETIPMASRGG A
//
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