ID F6PW84_MACMU Unreviewed; 216 AA.
AC F6PW84;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 27-JUL-2011, sequence version 1.
DT 24-JAN-2024, entry version 79.
DE RecName: Full=maleylacetoacetate isomerase {ECO:0000256|ARBA:ARBA00013199};
DE EC=5.2.1.2 {ECO:0000256|ARBA:ARBA00013199};
GN Name=GSTZ1 {ECO:0000313|EMBL:AFH32112.1};
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544 {ECO:0000313|EMBL:AFH32112.1};
RN [1] {ECO:0000313|EMBL:AFH32112.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Caudate {ECO:0000313|EMBL:AFE66902.1}, Testis
RC {ECO:0000313|EMBL:AFI35821.1}, and Thymus
RC {ECO:0000313|EMBL:AFH32112.1};
RX PubMed=25319552; DOI=10.1186/1745-6150-9-20;
RA Zimin A.V., Cornish A.S., Maudhoo M.D., Gibbs R.M., Zhang X., Pandey S.,
RA Meehan D.T., Wipfler K., Bosinger S.E., Johnson Z.P., Tharp G.K.,
RA Marcais G., Roberts M., Ferguson B., Fox H.S., Treangen T., Salzberg S.L.,
RA Yorke J.A., Norgren R.B.Jr.;
RT "A new rhesus macaque assembly and annotation for next-generation
RT sequencing analyses.";
RL Biol. Direct 9:20-20(2014).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=4-maleylacetoacetate = 4-fumarylacetoacetate;
CC Xref=Rhea:RHEA:14817, ChEBI:CHEBI:17105, ChEBI:CHEBI:18034;
CC EC=5.2.1.2; Evidence={ECO:0000256|ARBA:ARBA00001622};
CC -!- COFACTOR:
CC Name=glutathione; Xref=ChEBI:CHEBI:57925;
CC Evidence={ECO:0000256|ARBA:ARBA00001955};
CC -!- PATHWAY: Amino-acid degradation; L-phenylalanine degradation;
CC acetoacetate and fumarate from L-phenylalanine: step 5/6.
CC {ECO:0000256|ARBA:ARBA00004671}.
CC -!- SIMILARITY: Belongs to the GST superfamily. Zeta family.
CC {ECO:0000256|ARBA:ARBA00010007}.
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DR EMBL; JU323146; AFE66902.1; -; mRNA.
DR EMBL; JU475308; AFH32112.1; -; mRNA.
DR EMBL; JV045750; AFI35821.1; -; mRNA.
DR RefSeq; XP_001101990.1; XM_001101990.3.
DR AlphaFoldDB; F6PW84; -.
DR GeneID; 705723; -.
DR KEGG; mcc:705723; -.
DR CTD; 2954; -.
DR eggNOG; KOG0868; Eukaryota.
DR HOGENOM; CLU_011226_20_1_1; -.
DR OrthoDB; 986565at2759; -.
DR TreeFam; TF105324; -.
DR UniPathway; UPA00139; UER00340.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0016034; F:maleylacetoacetate isomerase activity; IEA:UniProtKB-EC.
DR GO; GO:0006559; P:L-phenylalanine catabolic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0006572; P:tyrosine catabolic process; IEA:UniProtKB-KW.
DR CDD; cd03191; GST_C_Zeta; 1.
DR CDD; cd03042; GST_N_Zeta; 1.
DR Gene3D; 1.20.1050.10; -; 1.
DR Gene3D; 3.40.30.10; Glutaredoxin; 1.
DR InterPro; IPR010987; Glutathione-S-Trfase_C-like.
DR InterPro; IPR036282; Glutathione-S-Trfase_C_sf.
DR InterPro; IPR040079; Glutathione_S-Trfase.
DR InterPro; IPR004045; Glutathione_S-Trfase_N.
DR InterPro; IPR004046; GST_C.
DR InterPro; IPR005955; GST_Zeta.
DR InterPro; IPR034330; GST_Zeta_C.
DR InterPro; IPR034333; GST_Zeta_N.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR NCBIfam; TIGR01262; maiA; 1.
DR PANTHER; PTHR42673; MALEYLACETOACETATE ISOMERASE; 1.
DR PANTHER; PTHR42673:SF4; MALEYLACETOACETATE ISOMERASE; 1.
DR Pfam; PF14497; GST_C_3; 1.
DR Pfam; PF13409; GST_N_2; 1.
DR SFLD; SFLDS00019; Glutathione_Transferase_(cytos; 1.
DR SFLD; SFLDG00358; Main_(cytGST); 1.
DR SUPFAM; SSF47616; GST C-terminal domain-like; 1.
DR SUPFAM; SSF52833; Thioredoxin-like; 1.
DR PROSITE; PS50405; GST_CTER; 1.
DR PROSITE; PS50404; GST_NTER; 1.
PE 2: Evidence at transcript level;
KW Isomerase {ECO:0000313|EMBL:AFH32112.1};
KW Phenylalanine catabolism {ECO:0000256|ARBA:ARBA00023232};
KW Tyrosine catabolism {ECO:0000256|ARBA:ARBA00022878}.
FT DOMAIN 4..87
FT /note="GST N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50404"
FT DOMAIN 92..212
FT /note="GST C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50405"
SQ SEQUENCE 216 AA; 24058 MW; 49490B7D31E16A58 CRC64;
MQAGKPILYS YFRSSCSWRV RIALALKGID YETVPINLIK DGGQQFSKDF QALNPMKQVP
ALKIDGITIH QSLAIIEYLE ETRPTPRLLP QDPKKRASVR MISDLIAGGI QPLQNLSVLK
QVGEEFQLTW AQNAIISGFN ALEQILQSTA GTYCVGDEVT MADLCLVPQV ANAERFKVDC
TPYPTISSIN KRLLVLEAFQ VTHPCRQPDT PTELRA
//
