ID F6QTT9_HORSE Unreviewed; 759 AA.
AC F6QTT9;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 2.
DT 27-MAR-2024, entry version 65.
DE RecName: Full=Protein VAC14 homolog {ECO:0000256|ARBA:ARBA00013840};
GN Name=VAC14 {ECO:0000313|VGNC:VGNC:24874};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000010638.2, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000010638.2, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000010638.2,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000010638.2}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000010638.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Microsome membrane
CC {ECO:0000256|ARBA:ARBA00004524}.
CC -!- SIMILARITY: Belongs to the VAC14 family.
CC {ECO:0000256|ARBA:ARBA00010225}.
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DR AlphaFoldDB; F6QTT9; -.
DR Ensembl; ENSECAT00000013402.3; ENSECAP00000010638.2; ENSECAG00000012459.4.
DR CTD; 55697; -.
DR VGNC; VGNC:24874; VAC14.
DR GeneTree; ENSGT00390000008385; -.
DR HOGENOM; CLU_007740_1_0_1; -.
DR OrthoDB; 5481081at2759; -.
DR TreeFam; TF343690; -.
DR Proteomes; UP000002281; Chromosome 3.
DR Bgee; ENSECAG00000012459; Expressed in zone of skin and 23 other cell types or tissues.
DR ExpressionAtlas; F6QTT9; baseline.
DR GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070772; C:PAS complex; IEA:InterPro.
DR GO; GO:0006661; P:phosphatidylinositol biosynthetic process; IEA:InterPro.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR026825; Vac14.
DR InterPro; IPR021841; VAC14_Fig4p-bd.
DR PANTHER; PTHR16023:SF0; PROTEIN VAC14 HOMOLOG; 1.
DR PANTHER; PTHR16023; TAX1 BINDING PROTEIN-RELATED; 1.
DR Pfam; PF12755; Vac14_Fab1_bd; 1.
DR Pfam; PF11916; Vac14_Fig4_bd; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022848};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Microsome {ECO:0000256|ARBA:ARBA00022848};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 519..697
FT /note="Vacuolar protein 14 C-terminal Fig4-binding"
FT /evidence="ECO:0000259|Pfam:PF11916"
FT REGION 329..348
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 759 AA; 85149 MW; F9F903F53EFF5FC7 CRC64;
MALTTTSQSA AELGKACPEN NTVQIKHVIQ TLSQEFALSQ HPHSRKGGLI GLAACSIALG
KDSGLYLKEL IEPVLTCFND ADSRLRYYAC EALYNIVKVA RGAVLPHFNV LFDGLSKLAA
DPDPNVKSGS ELLDRLLKDI VTESNRFDLV GFIPLLRERI YSNNQYARQF LISWILVLES
VPDINLLDYL PEILDGLFQI LGDNGKEIRK MCEVVLGEFL KEIKKNPSSV KFAEMANILV
IHCQTTDDLI QLTAMCWMRE FIQLAGRVML PYSSGILTAV LPCLAYDDRK KSIKEVANVC
NQSLMKLVTP EDDEPDELKP VVLRQAEPNP DDSLVKQEGT VSGGPSGSCD SSFSSGISVF
TPASTERAPV TLHLDGIVQV LNCHLSDTAI GMMTRIAVLK WLYHLYIKTP RKMFRHTDSL
FPILLQTLSD ESDEVILKDL EVLAEIASSP AGQTDDPGPL DGPDLQVRHS ELQVPPTGRA
GLMNTPGTKG LECSPSTPTM NSYFYKFMIN LLKRFSSERK LLEVRGAFII RQLCLLLNAE
NIFHSMADIL LQEEDLKFAS TMVHTLNTIL LTSTELFQLR NQLKDLRTLE SQNLFCCLYR
SWCHNPVTTV SLCFLTQNYR HAYDLIQKFG DLEVTVDFLT EVDKLVQLIE CPIFTYLRLQ
LLDVKNNPYL IKALYGLLML LPQSSAFQLL SHRLQCVPNP ELLQTEDSLK AAPKSQKADA
PSIDYAELLQ HFEKVQKKHL EVRHQRSGRG DHLDRKVVL
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