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Database: UniProt/TrEMBL
Entry: F6RH35_HORSE
LinkDB: F6RH35_HORSE
Original site: F6RH35_HORSE 
ID   F6RH35_HORSE            Unreviewed;       877 AA.
AC   F6RH35;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   30-AUG-2017, entry version 32.
DE   RecName: Full=Histone-lysine N-methyltransferase {ECO:0000256|PROSITE-ProRule:PRU00903};
DE            EC=2.1.1.43 {ECO:0000256|PROSITE-ProRule:PRU00903};
GN   Name=KMT5B {ECO:0000313|Ensembl:ENSECAP00000010835};
OS   Equus caballus (Horse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000010835, ECO:0000313|Proteomes:UP000002281};
RN   [1] {ECO:0000313|Ensembl:ENSECAP00000010835, ECO:0000313|Proteomes:UP000002281}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000010835,
RC   ECO:0000313|Proteomes:UP000002281};
RX   PubMed=19892987; DOI=10.1126/science.1178158;
RG   Broad Institute Genome Sequencing Platform;
RG   Broad Institute Whole Genome Assembly Team;
RA   Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA   Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H.,
RA   Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N.,
RA   Penedo M.C.T., Raison J.M., Sharpe T., Vogel J., Andersson L.,
RA   Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J.,
RA   Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J.,
RA   Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R.,
RA   Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F.,
RA   Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L.,
RA   Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M.,
RA   White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT   "Genome sequence, comparative analysis, and population genetics of the
RT   domestic horse.";
RL   Science 326:865-867(2009).
RN   [2] {ECO:0000313|Ensembl:ENSECAP00000010835}
RP   IDENTIFICATION.
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000010835};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY: S-adenosyl-L-methionine + L-lysine-[histone] =
CC       S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].
CC       {ECO:0000256|PROSITE-ProRule:PRU00903}.
CC   -!- SIMILARITY: Belongs to the class V-like SAM-binding
CC       methyltransferase superfamily. Histone-lysine methyltransferase
CC       family. Suvar4-20 subfamily. {ECO:0000256|PROSITE-
CC       ProRule:PRU00903}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSECAP00000010835}.
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DR   RefSeq; XP_001498718.1; XM_001498668.4.
DR   STRING; 9796.ENSECAP00000010835; -.
DR   PaxDb; F6RH35; -.
DR   PRIDE; F6RH35; -.
DR   Ensembl; ENSECAT00000013633; ENSECAP00000010835; ENSECAG00000012952.
DR   GeneID; 100053438; -.
DR   KEGG; ecb:100053438; -.
DR   CTD; 51111; -.
DR   eggNOG; KOG2589; Eukaryota.
DR   eggNOG; ENOG410XPH8; LUCA.
DR   GeneTree; ENSGT00520000055640; -.
DR   InParanoid; F6RH35; -.
DR   KO; K11429; -.
DR   OMA; SGCLTRH; -.
DR   OrthoDB; EOG091G0IUY; -.
DR   TreeFam; TF106433; -.
DR   Proteomes; UP000002281; Chromosome 12.
DR   Bgee; ENSECAG00000012952; -.
DR   GO; GO:0000780; C:condensed nuclear chromosome, centromeric region; IEA:Ensembl.
DR   GO; GO:0042799; F:histone methyltransferase activity (H4-K20 specific); IEA:UniProtKB-UniRule.
DR   GO; GO:0034773; P:histone H4-K20 trimethylation; IEA:UniProtKB-UniRule.
DR   InterPro; IPR025790; Hist-Lys_N-MTase_Suvar4-20.
DR   InterPro; IPR001214; SET_dom.
DR   Pfam; PF00856; SET; 1.
DR   SMART; SM00317; SET; 1.
DR   PROSITE; PS51570; SAM_MT43_SUVAR420_2; 1.
DR   PROSITE; PS50280; SET; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002281};
KW   Methyltransferase {ECO:0000256|PROSITE-ProRule:PRU00903};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW   S-adenosyl-L-methionine {ECO:0000256|PROSITE-ProRule:PRU00903};
KW   Transferase {ECO:0000256|PROSITE-ProRule:PRU00903}.
FT   DOMAIN      193    308       SET. {ECO:0000259|PROSITE:PS50280}.
SQ   SEQUENCE   877 AA;  97365 MW;  2FF1780D61C1589A CRC64;
     MKWLGEAKNM VVNGRRNGGK LSNDHQQTQP KVQHTGKDTV KAGRTAGERR SSRCNGNSGF
     EGQSRYVPSS GMSAKELCEN DDLATSLVLD PYLGFQTHKM NTSAFPSRSS RHFSKSDSFP
     HNNPVRFRPI KGRQEELKEV IERFKKDEHL EKAFKCLTSG EWARHYFLNK NKTQEKLFKE
     HVFIYLRMFA TDSGFEILPC NRYSSEQNGA KIVATKEWKR NDKIELLVGC IAELSEIEEN
     MLLRHGENDF SVMYSTRKNC AQLWLGPAAF INHDCRPNCK FVSTGRDTAC VKALRDIEPG
     EEISCYYGDG FFGENNEFCE CYTCERRGTG AFKSRVGLPA PAPVINSKYG LRETDKRLNR
     LKKLGDSSKN SDSQSVSSNT DADTTQEKNN ATSTRKSSIG VKKNSKGRGL TRPPASARST
     SSTLTHASSS RAPKTLRKPA KPLPSKTKLR NHCKRLEQKS ASRKLEMGNL VLKEPKVVLY
     KNLPIKKDKE PEGPVQANVA GGCLTRHAAR EHKQNSGRGA PSHGEGAPCT YTPRRSMRTR
     TNLKETSDIK LEPNMLDGYK DSSTEPCPDS GEQPTPAVQE EELAHETAQN GEAKCHKTDN
     SMSKKKSRQG KLVKQSAKPE ESTPVHDSPG KAGVALDVMG SHSDQGEHSG PEGLPGSYTD
     WAPSPGGGSV VTSDSFKAKD NFRTAKSKKK RRITRYDAQL ILENNSGIPK LTLRRRHDSS
     SKANDQESDG MNSSKISIKL SKDHENDNNL YVAKLNNGFN SGSGSSSTKL KIQLKRDEEG
     RGSYVEGLHE NGVCCSDPLS LLESQMEVGD YSQYEEESTD GPSSSEGDEE DDDDDDFEDD
     FIPLPPAKRL RLIVGKDSID IDISSRRRED QSLRLNA
//
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