ID F6SEB7_MACMU Unreviewed; 1270 AA.
AC F6SEB7;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 90.
DE SubName: Full=Tenascin R {ECO:0000313|Ensembl:ENSMMUP00000020646.3};
GN Name=TNR {ECO:0000313|Ensembl:ENSMMUP00000020646.3,
GN ECO:0000313|VGNC:VGNC:78609};
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000020646.3, ECO:0000313|Proteomes:UP000006718};
RN [1] {ECO:0000313|Proteomes:UP000006718}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=17573 {ECO:0000313|Proteomes:UP000006718};
RX PubMed=17431167; DOI=10.1126/science.1139247;
RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., Wilson R.K.,
RA Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., Hardison R.C.,
RA Makova K.D., Miller W., Milosavljevic A., Palermo R.E., Siepel A.,
RA Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., Dinh H.H.,
RA Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., Godfrey J.,
RA Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N.,
RA Joshi V., Khan Z.M., Kirkness E.F., Cree A., Fowler R.G., Lee S.,
RA Lewis L.R., Li Z., Liu Y.-S., Moore S.M., Muzny D., Nazareth L.V.,
RA Ngo D.N., Okwuonu G.O., Pai G., Parker D., Paul H.A., Pfannkoch C.,
RA Pohl C.S., Rogers Y.-H.C., Ruiz S.J., Sabo A., Santibanez J.,
RA Schneider B.W., Smith S.M., Sodergren E., Svatek A.F., Utterback T.R.,
RA Vattathil S., Warren W., White C.S., Chinwalla A.T., Feng Y., Halpern A.L.,
RA Hillier L.W., Huang X., Minx P., Nelson J.O., Pepin K.H., Qin X.,
RA Sutton G.G., Venter E., Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P.,
RA Jones S.M., Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L.,
RA Csuros M., Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H.,
RA Liu Y., Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., Denby A.,
RA Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., Marklein A.,
RA Nielsen R., Vallender E.J., Clark A.G., Ferguson B., Hernandez R.D.,
RA Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., Pu L.-L., Ren Y.,
RA Smith D.G., Wheeler D.A., Schenck I., Ball E.V., Chen R., Cooper D.N.,
RA Giardine B., Hsu F., Kent W.J., Lesk A., Nelson D.L., O'brien W.E.,
RA Pruefer K., Stenson P.D., Wallace J.C., Ke H., Liu X.-M., Wang P.,
RA Xiang A.P., Yang F., Barber G.P., Haussler D., Karolchik D., Kern A.D.,
RA Kuhn R.M., Smith K.E., Zwieg A.S.;
RT "Evolutionary and biomedical insights from the rhesus macaque genome.";
RL Science 316:222-234(2007).
RN [2] {ECO:0000313|Ensembl:ENSMMUP00000020646.3}
RP IDENTIFICATION.
RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000020646.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
CC -!- SIMILARITY: Belongs to the tenascin family.
CC {ECO:0000256|ARBA:ARBA00008673}.
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DR AlphaFoldDB; F6SEB7; -.
DR SMR; F6SEB7; -.
DR Ensembl; ENSMMUT00000022070.4; ENSMMUP00000020646.3; ENSMMUG00000015723.4.
DR VEuPathDB; HostDB:ENSMMUG00000015723; -.
DR VGNC; VGNC:78609; TNR.
DR eggNOG; KOG1225; Eukaryota.
DR eggNOG; KOG2579; Eukaryota.
DR GeneTree; ENSGT00940000157761; -.
DR TreeFam; TF329915; -.
DR Proteomes; UP000006718; Chromosome 1.
DR Bgee; ENSMMUG00000015723; Expressed in dorsolateral prefrontal cortex and 7 other cell types or tissues.
DR ExpressionAtlas; F6SEB7; baseline.
DR CDD; cd00063; FN3; 8.
DR CDD; cd00087; FReD; 1.
DR Gene3D; 3.90.215.10; Gamma Fibrinogen, chain A, domain 1; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 8.
DR Gene3D; 2.10.25.10; Laminin; 4.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR013111; EGF_extracell.
DR InterPro; IPR041161; EGF_Tenascin.
DR InterPro; IPR036056; Fibrinogen-like_C.
DR InterPro; IPR014716; Fibrinogen_a/b/g_C_1.
DR InterPro; IPR002181; Fibrinogen_a/b/g_C_dom.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR NCBIfam; NF040941; GGGWT_bact; 1.
DR PANTHER; PTHR46708; TENASCIN; 1.
DR PANTHER; PTHR46708:SF6; TENASCIN-R; 1.
DR Pfam; PF07974; EGF_2; 1.
DR Pfam; PF18720; EGF_Tenascin; 2.
DR Pfam; PF00147; Fibrinogen_C; 1.
DR Pfam; PF00041; fn3; 8.
DR SMART; SM00181; EGF; 4.
DR SMART; SM00186; FBG; 1.
DR SMART; SM00060; FN3; 8.
DR SUPFAM; SSF56496; Fibrinogen C-terminal domain-like; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 4.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS51406; FIBRINOGEN_C_2; 1.
DR PROSITE; PS50853; FN3; 8.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536};
KW Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000006718};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022530}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..31
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 32..1270
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5023807559"
FT DOMAIN 329..418
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 419..507
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 508..599
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 600..689
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 690..777
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 778..867
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 868..954
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 955..1042
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1041..1256
FT /note="Fibrinogen C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51406"
FT COILED 127..154
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1270 AA; 140077 MW; 355CE8E630721388 CRC64;
MGADGETVVL KNMLIGVNLI LLGSMLKPSE CQLEVTTERV QRQSVEEEGG IANYNTSSKE
QPVVFNHVYN INVPLDSLCS SGLEASAEQD VSAEDETVAE YTGQTSDHES QVTFTHRINL
PKKACPCASS AQMLQELLSR IEMLEREVSV LRDQCNANCC QESAATGQLD YIPHCSGHGN
FSFESCGCIC NEGWFGKNCS EPYCPLGCSS RGVCVDGQCI CDSEYSGDDC SELRCPTDCS
SRGLCVDGEC VCEEPYTGED CRELRCPGDC SGKGRCANGT CLCEEGYVGE DCGQRQCLNA
CSGRGQCEEG LCICEEGYQG PDCSADLSTP QGLQFKTITE TTVEVQWEPF SFSFDGWEIS
FIPKNNEGGV IAQVPSDVTS FNQTGLKPGE EYIVNVVALK EQARSPPTSA SVSTVIDGPT
QILVRDVSDT VAFVEWIPPR AKVDFILLKY GLVGGEGGRT TFRLQPPLSQ YSVQALRPGS
RYEVSVSAVR GTNESDSATT QFTTEIDAPK NLRVGSRTAT SLDLEWDNSE AEVQEYKVIY
STLAGEQYHE VLVPKGIGPT TRTTLTDLVP GTEYGVGISA IMNSQQSVPA TMNARTELDS
PRDLMVTASS ETSISLIWTK ASGPIDHYRI TFTPSSGIAS EVTVPKDRTS YTLTDLEPGA
EYIISITAER GRQQSLESTV DAFTGFRPIS HLHFSHVTSS SVNITWSDPS PPADRLILNY
SPRDEEEEMT EVSLDATKRH AVLMGLQPAT EYIVNLVAVH GTVTSEPIVG SITTGIDPPK
DITISNVTKD SVMVSWSPPV ASFDYYRVSY RPTQVGRLDS SVVPNTVTEF TITRLYPATE
YEISLNSVRG REESERICTL VHTAMDNPVD LTATNITPTE ALLQWKAPVG EVENYVIVLT
HFAVAGETIL VDGVSEEFRL VDLLPSTHYT ATMYATNGPL TSGTISTNFS TLLDPPANLT
ASEVTRQSAL ISWQPPRAEI ENYVLTYKST DGSRKELIVD AEDTWIRLEG LLENTDYTVL
LQAAQDTVWS SITSTAFTTG GRVFPHPQDC AQHLMNGDTL SGVYPIFLNG ELSQKLQVYC
DMTTDGGGWI VFQRRQNGQT DFFRKWADYR VGFGNLEDEF WLGLDNIHRI TSQGRYELRV
DMRDGQEAAF ASYDRFSVED NRNLYKLRIG SYNGTAGDSL SYHQGRPFST EDRDNDVAVT
NCAMSYKGAW WYKNCHRTNL NGKYGESRHS QGINWYHWKG HEFSIPFVEM KMRPYSHRLM
AGRKRQSLQF
//
