GenomeNet

Database: UniProt/TrEMBL
Entry: F6TFD4_MONDO
LinkDB: F6TFD4_MONDO
Original site: F6TFD4_MONDO 
ID   F6TFD4_MONDO            Unreviewed;       689 AA.
AC   F6TFD4;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   09-JAN-2013, sequence version 2.
DT   25-APR-2018, entry version 43.
DE   SubName: Full=Transglutaminase 2 {ECO:0000313|Ensembl:ENSMODP00000000237};
GN   Name=TGM2 {ECO:0000313|Ensembl:ENSMODP00000000237};
OS   Monodelphis domestica (Gray short-tailed opossum).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Metatheria; Didelphimorphia; Didelphidae; Monodelphis.
OX   NCBI_TaxID=13616 {ECO:0000313|Ensembl:ENSMODP00000000237, ECO:0000313|Proteomes:UP000002280};
RN   [1] {ECO:0000313|Ensembl:ENSMODP00000000237, ECO:0000313|Proteomes:UP000002280}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=17495919; DOI=10.1038/nature05805;
RA   Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L.,
RA   Duke S., Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J.,
RA   Kamal M., Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A.,
RA   Benos P.V., Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L.,
RA   Deakin J.E., Fazzari M.J., Glass J.L., Grabherr M., Greally J.M.,
RA   Gu W., Hore T.A., Huttley G.A., Kleber M., Jirtle R.L., Koina E.,
RA   Lee J.T., Mahony S., Marra M.A., Miller R.D., Nicholls R.D., Oda M.,
RA   Papenfuss A.T., Parra Z.E., Pollock D.D., Ray D.A., Schein J.E.,
RA   Speed T.P., Thompson K., VandeBerg J.L., Wade C.M., Walker J.A.,
RA   Waters P.D., Webber C., Weidman J.R., Xie X., Zody M.C., Baldwin J.,
RA   Abdouelleil A., Abdulkadir J., Abebe A., Abera B., Abreu J.,
RA   Acer S.C., Aftuck L., Alexander A., An P., Anderson E., Anderson S.,
RA   Arachi H., Azer M., Bachantsang P., Barry A., Bayul T., Berlin A.,
RA   Bessette D., Bloom T., Bloom T., Boguslavskiy L., Bonnet C.,
RA   Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA   Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P.,
RA   Costello M., D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C.,
RA   Dhargay N., Dooley K., Dooley E., Doricent M., Dorje P., Dorjee K.,
RA   Dupes A., Elong R., Falk J., Farina A., Faro S., Ferguson D.,
RA   Fisher S., Foley C.D., Franke A., Friedrich D., Gadbois L., Gearin G.,
RA   Gearin C.R., Giannoukos G., Goode T., Graham J., Grandbois E.,
RA   Grewal S., Gyaltsen K., Hafez N., Hagos B., Hall J., Henson C.,
RA   Hollinger A., Honan T., Huard M.D., Hughes L., Hurhula B., Husby M.E.,
RA   Kamat A., Kanga B., Kashin S., Khazanovich D., Kisner P., Lance K.,
RA   Lara M., Lee W., Lennon N., Letendre F., LeVine R., Lipovsky A.,
RA   Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y., Lubonja R.,
RA   Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA   McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA   Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A.,
RA   Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N.,
RA   Nicol R., Norbu C., Norbu N., Novod N., O'Neill B., Osman S.,
RA   Markiewicz E., Oyono O.L., Patti C., Phunkhang P., Pierre F.,
RA   Priest M., Raghuraman S., Rege F., Reyes R., Rise C., Rogov P.,
RA   Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L., Shih D.,
RA   Sparrow T., Spaulding J., Stalker J., Stange-Thomann N.,
RA   Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T.,
RA   Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T.,
RA   Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J.,
RA   Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A.,
RA   Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C.,
RA   Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M.,
RA   Samollow P.B., Lander E.S., Lindblad-Toh K.;
RT   "Genome of the marsupial Monodelphis domestica reveals innovation in
RT   non-coding sequences.";
RL   Nature 447:167-177(2007).
RN   [2] {ECO:0000313|Ensembl:ENSMODP00000000237}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC         Evidence={ECO:0000256|PIRSR:PIRSR000459-2};
CC       Note=Binds 1 Ca(2+) ion per subunit.
CC       {ECO:0000256|PIRSR:PIRSR000459-2};
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DR   RefSeq; XP_007474431.1; XM_007474369.2.
DR   STRING; 13616.ENSMODP00000000237; -.
DR   Ensembl; ENSMODT00000000241; ENSMODP00000000237; ENSMODG00000000203.
DR   GeneID; 100032853; -.
DR   KEGG; mdo:100032853; -.
DR   CTD; 7052; -.
DR   eggNOG; ENOG410IFMV; Eukaryota.
DR   eggNOG; ENOG410XQEZ; LUCA.
DR   GeneTree; ENSGT00760000119108; -.
DR   InParanoid; F6TFD4; -.
DR   KO; K05625; -.
DR   OrthoDB; EOG091G030K; -.
DR   TreeFam; TF324278; -.
DR   Proteomes; UP000002280; Chromosome 1.
DR   Bgee; ENSMODG00000000203; -.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:GOC.
DR   GO; GO:0031226; C:intrinsic component of plasma membrane; IEA:Ensembl.
DR   GO; GO:0005739; C:mitochondrion; IEA:Ensembl.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0003810; F:protein-glutamine gamma-glutamyltransferase activity; IEA:Ensembl.
DR   GO; GO:0043277; P:apoptotic cell clearance; IEA:Ensembl.
DR   GO; GO:0060445; P:branching involved in salivary gland morphogenesis; IEA:Ensembl.
DR   GO; GO:0032471; P:negative regulation of endoplasmic reticulum calcium ion concentration; IEA:Ensembl.
DR   GO; GO:0018149; P:peptide cross-linking; IEA:InterPro.
DR   GO; GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl.
DR   GO; GO:0045785; P:positive regulation of cell adhesion; IEA:Ensembl.
DR   GO; GO:0051561; P:positive regulation of mitochondrial calcium ion concentration; IEA:Ensembl.
DR   GO; GO:0060662; P:salivary gland cavitation; IEA:Ensembl.
DR   Gene3D; 2.60.40.10; -; 3.
DR   Gene3D; 3.90.260.10; -; 1.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR002931; Transglutaminase-like.
DR   InterPro; IPR036985; Transglutaminase-like_sf.
DR   InterPro; IPR023608; Transglutaminase_animal.
DR   InterPro; IPR013808; Transglutaminase_AS.
DR   InterPro; IPR008958; Transglutaminase_C.
DR   InterPro; IPR036238; Transglutaminase_C_sf.
DR   InterPro; IPR001102; Transglutaminase_N.
DR   Pfam; PF00927; Transglut_C; 2.
DR   Pfam; PF01841; Transglut_core; 1.
DR   Pfam; PF00868; Transglut_N; 1.
DR   PIRSF; PIRSF000459; TGM_EBP42; 1.
DR   SMART; SM00460; TGc; 1.
DR   SUPFAM; SSF49309; SSF49309; 2.
DR   SUPFAM; SSF81296; SSF81296; 1.
DR   PROSITE; PS00547; TRANSGLUTAMINASES; 1.
PE   4: Predicted;
KW   Calcium {ECO:0000256|PIRSR:PIRSR000459-2};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002280};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR000459-2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002280}.
FT   DOMAIN      269    361       TGc. {ECO:0000259|SMART:SM00460}.
FT   ACT_SITE    277    277       {ECO:0000256|PIRSR:PIRSR000459-1}.
FT   ACT_SITE    335    335       {ECO:0000256|PIRSR:PIRSR000459-1}.
FT   ACT_SITE    358    358       {ECO:0000256|PIRSR:PIRSR000459-1}.
FT   METAL       398    398       Calcium. {ECO:0000256|PIRSR:PIRSR000459-
FT                                2}.
FT   METAL       400    400       Calcium. {ECO:0000256|PIRSR:PIRSR000459-
FT                                2}.
FT   METAL       447    447       Calcium. {ECO:0000256|PIRSR:PIRSR000459-
FT                                2}.
FT   METAL       452    452       Calcium. {ECO:0000256|PIRSR:PIRSR000459-
FT                                2}.
SQ   SEQUENCE   689 AA;  78203 MW;  57C3293D8EC6AE01 CRC64;
     MTKALVIDKI NQDYEKNGKN HRTSALTQDR LVLRRGQSFS ISLTFHGRGF EASTDKLFFL
     VETGPRPNET VFTKAKFPLS TTHSEGSWEA SMVSQEGHTL NLAFSSPANA PIGYYKLSME
     SITGSQHHIS SITGFVLLFN PWCKEDSVYM EEEEFRQEYV MNQHGLIFQG APACIEKIPW
     NFGQFEDGIL DICIELMDMN PKFIRDCGRD CSRRNSPIYV SRVISAMVNC NDDKGILFGR
     WDNNYKDGIN PMSWIGSVDI LKKWKKSGCC QVKYGQCWVF AAVACTVLRC LGIPSRVVTN
     YNSAHDSNAN LVVDLYTDEK GMTVKHSNES IWNYHCWTES WMTRPDLKPE CNGWQVIDPT
     PQEKSEGAFC CGPASVNAIK NGDVNTKYDA PFVFAEVNAD VVKWIKKSNG TTEKAYTETT
     IVGMMISTKA VGKDEREDIT HLYKYPENSK EERESFKRAN HMNKLGCRDD PSSDEKLKIK
     IKVSPDMNKG NDFDVFAMIK NGFSEEQTCH LLIMARTMSY NGILGPECAK KEMHSVTLEP
     LSEKKIPLRI SYANYRDHLN DSNLIKVQVF LQHLQSQFFF LSERDIYLLN PEIKIRILGE
     PKQFRKLVAE LSVKNPLHVP LHDCAFTVEG AGLTQGQKIA RVPEPVEPGN TVTTRMDLMP
     RWPGLHKLVV NFESDKMKAV KGYWNVIIG
//
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