ID F6TL59_CALJA Unreviewed; 4909 AA.
AC F6TL59;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 3.
DT 27-MAR-2024, entry version 89.
DE RecName: Full=[histone H3]-lysine(4) N-methyltransferase {ECO:0000256|ARBA:ARBA00023620};
DE EC=2.1.1.364 {ECO:0000256|ARBA:ARBA00023620};
GN Name=KMT2C {ECO:0000313|Ensembl:ENSCJAP00000036659.4};
OS Callithrix jacchus (White-tufted-ear marmoset).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Callitrichinae; Callithrix; Callithrix.
OX NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000036659.4, ECO:0000313|Proteomes:UP000008225};
RN [1] {ECO:0000313|Ensembl:ENSCJAP00000036659.4}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCJAP00000036659.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = H(+) +
CC N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine;
CC Xref=Rhea:RHEA:60264, Rhea:RHEA-COMP:15543, Rhea:RHEA-COMP:15547,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856,
CC ChEBI:CHEBI:59789, ChEBI:CHEBI:61929; EC=2.1.1.364;
CC Evidence={ECO:0000256|ARBA:ARBA00024515};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:60265;
CC Evidence={ECO:0000256|ARBA:ARBA00024515};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR STRING; 9483.ENSCJAP00000036659; -.
DR Ensembl; ENSCJAT00000038717.4; ENSCJAP00000036659.4; ENSCJAG00000019672.6.
DR eggNOG; KOG4443; Eukaryota.
DR GeneTree; ENSGT00940000155281; -.
DR InParanoid; F6TL59; -.
DR OMA; MYCKHLE; -.
DR TreeFam; TF354317; -.
DR Proteomes; UP000008225; Chromosome 8.
DR Bgee; ENSCJAG00000019672; Expressed in cerebellum and 6 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0044666; C:MLL3/4 complex; IEA:Ensembl.
DR GO; GO:0140999; F:histone H3K4 trimethyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd15696; ePHD1_KMT2C; 1.
DR CDD; cd15697; ePHD2_KMT2C; 1.
DR CDD; cd22026; HMG-box_KMT2C; 1.
DR CDD; cd15509; PHD1_KMT2C_like; 1.
DR CDD; cd15594; PHD2_KMT2C; 1.
DR CDD; cd15511; PHD3_KMT2C; 1.
DR CDD; cd15596; PHD4_KMT2C; 1.
DR CDD; cd15513; PHD5_KMT2C_like; 1.
DR CDD; cd15600; PHD6_KMT2C; 1.
DR CDD; cd19171; SET_KMT2C_2D; 1.
DR Gene3D; 3.30.160.360; -; 1.
DR Gene3D; 1.10.30.10; High mobility group box domain; 1.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 7.
DR InterPro; IPR034732; EPHD.
DR InterPro; IPR003889; FYrich_C.
DR InterPro; IPR003888; FYrich_N.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR InterPro; IPR000637; HMGI/Y_DNA-bd_CS.
DR InterPro; IPR041967; KMT2C_ePHD1.
DR InterPro; IPR041968; KMT2C_ePHD2.
DR InterPro; IPR047004; KMT2C_PHD2.
DR InterPro; IPR047003; KMT2C_PHD4.
DR InterPro; IPR047005; KMT2C_PHD6.
DR InterPro; IPR037877; PHD3_KMT2C.
DR InterPro; IPR003616; Post-SET_dom.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR45888:SF1; HISTONE-LYSINE N-METHYLTRANSFERASE 2C; 1.
DR PANTHER; PTHR45888; HL01030P-RELATED; 1.
DR Pfam; PF05965; FYRC; 1.
DR Pfam; PF05964; FYRN; 1.
DR Pfam; PF00628; PHD; 4.
DR Pfam; PF00856; SET; 1.
DR Pfam; PF13771; zf-HC5HC2H; 1.
DR Pfam; PF13832; zf-HC5HC2H_2; 1.
DR SMART; SM00542; FYRC; 1.
DR SMART; SM00541; FYRN; 1.
DR SMART; SM00398; HMG; 1.
DR SMART; SM00249; PHD; 8.
DR SMART; SM00508; PostSET; 1.
DR SMART; SM00317; SET; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 6.
DR SUPFAM; SSF47095; HMG-box; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS50216; DHHC; 1.
DR PROSITE; PS51805; EPHD; 2.
DR PROSITE; PS51543; FYRC; 1.
DR PROSITE; PS51542; FYRN; 1.
DR PROSITE; PS00354; HMGI_Y; 1.
DR PROSITE; PS50868; POST_SET; 1.
DR PROSITE; PS50280; SET; 1.
DR PROSITE; PS50016; ZF_PHD_2; 6.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Methylation {ECO:0000256|ARBA:ARBA00022481};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000008225};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 227..331
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS51805"
FT DOMAIN 341..391
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 344..389
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 388..438
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 464..520
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 951..1004
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 1001..1051
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 1078..1133
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 4397..4505
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS51805"
FT DOMAIN 4769..4885
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT DOMAIN 4893..4909
FT /note="Post-SET"
FT /evidence="ECO:0000259|PROSITE:PS50868"
FT REGION 1..79
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 164..203
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 822..858
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 879..906
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1211..1317
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1400..1426
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1452..1481
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1593..1626
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1703..2447
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2569..2635
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2650..2727
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2786..2884
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2922..2944
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3199..3226
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3331..3406
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3520..3580
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3592..3740
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3812..3917
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4022..4051
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 3228..3265
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 10..26
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 34..50
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 836..853
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1219..1266
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1400..1416
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1460..1480
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1703..1723
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1724..1751
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1752..1817
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1827..1841
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1857..1887
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1912..1957
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1986..2000
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2028..2046
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2075..2153
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2154..2173
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2174..2195
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2198..2217
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2223..2246
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2255..2269
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2270..2284
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2296..2312
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2324..2371
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2381..2395
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2424..2440
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2621..2635
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2650..2677
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2678..2701
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2786..2802
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2803..2824
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2827..2844
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2845..2860
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2861..2875
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3212..3226
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3355..3375
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3388..3406
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3520..3549
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3565..3580
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3619..3652
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3668..3701
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3706..3725
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3825..3840
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3841..3876
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3877..3895
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3896..3910
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4909 AA; 541269 MW; 63E57ABEE6EDA6CF CRC64;
MSSEEDKSVE QPQPPPPPPE EPGAPAPSPA AADKRPRGRP RKDGASPFQR ARKKPRGRGK
TAVEDEDSMD GLETTETETI METEIKEQSA EEDAEAEVDN SKQLIPTLQR SVSEESANSL
VSVGVEAKIS EQLCAFCYCG EKSSLGQGDL KQFRVTPGFI LPWRNQPSNK KDIDDNSNGT
YEKMQNSAPR KQRGQRKERS PQQNIVSCVS VSTQTTSDDQ AGKLWDELSL VGLPDAIDVQ
ALFDSTGTCW AHHRCVEWSL GVCQMEEPLL VNVDKAVVSG STERCAFCKH LGATIKCCEE
KCTQMYHYPC AAGAGTFQDF SHIFLLCPEH IDQAPERSKE DANCAVCDSP GDLLDQFFCT
TCGQHYHGMC LDIAVTPLKR AGWQCPECKV CQNCKQSGED SKMLVCDTCD KGYHTFCLQP
VMKSVPTNGW KCKNCRICIE CGTRSSSQWH HNCLICDSCY QQQDNLCPFC GKCYHPELQK
DMLHCNMCKR WVHLECDKPT DHELDTQLKE EYICMYCRHL GAEMDPLQPG EEVEIAVLTT
DYNNEMEVEG PEDQMVFSEH AVNKDVNSQE STPGIVPDVI QVHTEEQQES HPPESLDTDG
LFIAGSFQHK INTELEKEIS NEVGSEEMKM SSEVKPICGE DRIEDKMEVT ENIEVVTHQI
IVQEEEMQLL EEPKTVVSKE ESRPPNIVVE SIILPPETLV SAHEESTSLC SERLQIEKEQ
KENSEFSTGL MDSEMTPAIE SCVKDGSYQG EKSVKLLPET ESSFASSADI CKTDVSSSPT
PSSDLPSHDM LHNYPSALSS SAGNIMPTTY ISVTPKIGMG KPAITKRKFS PGRPRSKQGA
WSTHNTVSPP SWSPDISEGR EIFKPRQLPG SAIWSIKVGR GSGFPGKRRP RGAGLSGRGG
RGRSKLKSGI GAVVLPGVST ADISSNKDDE ENSMHNTVVL FSSSDKFTLN QDMCVVCGSF
GQGAEGRLLA CSQCGQCYHP YCVSIKITKV VLSKGWRCLE CTVCEACGKA TDPGRLLLCD
DCDISYHTYC LDPPLQTVPK GGWKCKWCVW CRHCGATSAG LRCEWQNNYT QCAPCASLSS
CPVCYRNYRE EDLILQCRQC DRWMHAVCQN LNTEEEVENV ADIGFDCSMC RPYMPASNVP
SSDCCESSLV AQIVTKVKEL DPPKTYTQDG VCLTESGMTQ LQSLTVTVPR RKRSKPKLKL
KIINQNSVAV LQTPPDIQSE HSRDGEMDDS REAELMDCDG KSESSPEREA VDDETKGVEG
TDGVKKRKRK PYRPGIGGFM VRQRSRTGQG KTKRSVIRKD SSGSVSEQLP CRDDGWSEQL
PDTLVDESVS VIESTEKIKK RYRKRKNKLE ETFPAYLQEA FFGKDLLDTS RQSKLSLDNL
SEDAAQLSCK TNMNTGFLDP SLDPLLSSSS APTKSGTHGP ADDPLADISE VLNTDDDILG
IISDDLAKSV DHSDIGPVTD DPSSLPQPNV SQSSRPLSEE QLDGILSPEL DKMVTDGAIL
GKLYKIPELG GKDVEDLFTA VLSPANTQPA PVPQPPPPTQ LLPIHNQDVF SRMPLINGLI
GPSPHLPHNS LPPGSGLGTF SAIAQSPYPD ARDKNSTFNP MASDPSNSWT SSAPSVEGEN
DTMSNAQRST LKWEKEEALG EMATVAPVLY TNINFPNLKE EFPDWTTRVK QIAKLWRKAS
SQERAPYVQK ARDNRAALRI NKVQMSNDSM KRQQQQDSID PSSRVDSELF KDPLKQRESE
HEQEWKFRQQ MRQKSKQQAK IEATQKLEQV KNEQQQQQQQ QFGSQHLLVQ SGSDTPSSGI
QSPLTPQPGN GSMSPAQSFH KELFVKQPPS TPTSTSSDDV FVKPQAPPPP PAPSRIPIQE
SLSQAQTSQP PSPQVFSPGS SNSRPPSPMD PYAKMVGTPR PPPVGHSFSR RNSAAPVETC
TPLSVSRPIQ VNETVANRPS PVRDLCSSST TNNDPYAKPP DTPRPVMTDQ FPKSLGLARS
PIVSEQTAKG PVTAGTTDHF TKPSPRADVF QRQRIPDPYA RPLLTPAPLD GGPGPFKTPM
QPPPSAQDPY GSVSQASRRL SIDPYERPAL TPRPIDNFSH NQSNDPYSQP PLTTHPAMNE
SFAHPSRTFS QPGTISRPTS QDSYSQPPGT PRPVVDSYSQ SSGTARSNTD PYSQPPGTPR
PATVEPYSQQ PPTPRPSTQT DLFVTSVTNQ RHSDPYAHPP GTPRPGISVP YTQPPATPRP
RISEGFTRSS MTRPVLMPNQ DPFLQVAQNR GPALPGPLVR PPDICSQTPR PPGPSLSDTF
SRVSPSAARD PYDQPPVTPR SQSDSFGTSQ AAHDVADQPR PGSEGSFCAS SNSPMHSQGQ
QFSGVSQLPG PVPSSGVTDT QNTVNMSQAD TEKLRQRQKL REIILQQQQQ KKIAGRQEKG
SQDSPAVPHP GPLQHWQPEN INQAFTRPPP PYPGNIRSPV APPLGPRYGV FPKDQRGPYP
PDVASMGMRP HGFRFGFPGG SHGTMPSQER FLVPPQQIQA SGVSPQLRRS ISVDMPRPLN
NSQMNNPVGL PQHFSPQSLP VQQHNILGQA YIELRHRAPD GRQRLPFSAP PGSVVEASSN
LRHGNFIPRP DFPGPRHTEP MRRPPQCLPN QLPVHPDLEQ APPSQQEQGH SVHSSSMVMR
TLNHQLGAEF SEAPSSTSVS SETTSDNLQI TTQPSDGLEE KLDSDDPSVK ELDVKDLEGV
EVKDLDDEDL ENLNLDTEDG KGDELDTLDN LETNDPNLDD LLRSGEFDII AYTDPELDLG
DKKSMFNEEL DLPIDDKLDN QCVSVEPKTK EQEDKTLVLS DKHSPQKKST VTNEVKTEVL
SPNSKVESKC EIEKNDENKD KRVDTPCSQA SAQSDLNDGE KTSLHPCDPD LLEKRTNPET
AGSSANVIQG STQLPAQDVI NSCGITGSTP VLSSLLANEK SDNSDIRPLG SPPPTLPASP
SNHVSSLPSL IAPPGHVLDN TMNSNVTVVS RVNHVFSQGV QLNPGFIPGQ ATVNHNMGTG
KPTTQTVPLT SQSGTSSMSG PQQLMIPPQT LAQQNRERPL LLEEQPLLLQ DLLDQERQEQ
QQQRQMQAMI RQRSEPFFPN IDFDAITDPI MKAKMVALKG INKVMAQNNL GMPPMVMSRF
PFMGQAVTGT QTSEGQNLGT QAIPQDGSIT HQISRPNPPN FGPGFVNDSQ RKQYEEWLQE
TQQLLQMQQK YLEEQIGAHR KSKKALSAKQ RTAKKAGREF PEEDAEQLKH VTEQQSMVQK
QLEQIRKQQK EHAELIEDYR IKQQQQQQQC GMTPPTLMPG VQPQPPLIPG ATPPTMSQPA
FPMVPQQLQH QQHTAVISGH TSPVRMPSLP GWQPSSASAH LPLNPPRIQP PVAQLPLKTC
TSAPGTVSNA NPQSGPPPRV EFDDNNPFSE SFQERERKER LREQQERQRI QLMQEVDRQR
ALQQRMEMEQ HGMVGSEISS SRTSVSQIPF YSSDLPCDFM QPPRPLQQSP QHQQQMGQVL
QQQKMQQGSI NSPSTQTFMQ TNERRQVGPP SFVPDSPSIP VGSPNFSSVK QGHGNLPGTS
FQQSPVRPSF TPALPAAPPV ANSSLPCGQD PSITHGQSYP GSAQSLIQLY SDIIPEEKGK
KKRTRKKKKD DDAESTKAPS TPHSDITAPP TPSISETTST PAVSTPSEPL QQAEQELVEP
AGPSTPNMAA GQLCTELENK LPNSDFSQAT PNQQTYANIE VDRPSMETPA KIEEIKLEKA
ETESCPGQEE PTLEEQNGSK VEGNAVACAV SSAQSPPHSA GATAAKGDSG NELLKHLLKN
KKASFLLNQK PEGSICSEDD CTKDNKLVEK QNPAEGLQTL GAQMQGGFGC GNNQLAKTDG
GSETKKQRSK RTPRTGEKAA PRSKKRKKDE EEKQAMYSST DTFTHLKQQN NLSNPPTPPA
SLPPTPPPMA CQKMANGFAT TEELAGKTGV LVSHEVTKTL GPKPFQLPFR PQDDLLARAL
AQGPKTVDVP ASLPTPPHNN QEELRIQDHC GDRDTPDSFV PSSSPESVVG VEVSRYPDLS
LVKEEPPEPV PSPIIPILPS TAGKSSESRR NDIKTEPGTL YFASPFGSSP NGPRSGLISV
AITLHPTAAE NISSVVAAFS DLLHVRIPNS YEVSNAPDVP SMGLVSSHRI NPGLEYRQHL
LLRGPPPGSA NPPRLVSSYR LKQPNIPFSP TSNGLSGYKD SSHGIAESAA LRPQWCCHCK
VVILGSGVRK SFKDLTLLNK DSRESTKRVE KDIVFCSNNC FILYSSTAQA KNSENKESIP
SLPQSPMRET PSKAFHQYSN NISTLDVHCL PQLQEKASPP ASPPIAFPPA FEAAKVEAKP
DELKVTVKLK PRLRTVHGGF EDCRPLNKKW RGMKWKKWSI HIVIPKGTFK PPCEDEIDEF
LKKLGSSLKP DPVPKDYRKC CFCHEEGDGL TDGPARLLNL DLDLWVHLNC ALWSTEVYET
QAGALINVEL ALRRGLQMKC VFCHKTGATS GCHRFRCTNI YHFTCAIKAQ CMFFKDKTML
CPMHKPKGIH EQELSYFAVF RRVYVQRDEV RQIASIVQRG ERDHTFRVGS LIFHTIGQLL
PQQMQAFHSP KALFPVGYEA SRLYWSTRYA NRRCRYLCSI EEKDGHPVFV IRIVEQGHED
LVLSDVSPKG VWDKILEPVA CVRKKSEMLQ LFPAYLKGED LFGLTVSAVA RIAESLPGVE
ACENYNFRYG RNPLMELPLA INPTGCARSE PKMSAHVKRF VLRPHTLNST STSKSFQSTV
TGELNAPYSK QFVHSKSSQY RKMKTEWKSN VYLARSRIQG LGLYAARDIE KHTMVIEYIG
TIIRNEVANR KEKLYESQNR GVYMFRMDND HVIDATLTGG PARYINHSCA PNCVAEVVTF
ERGHKIIISS NRRIQKGEEL CYDYKFDFED DQHKIPCHCG AVNCRKWMN
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