ID F6YXZ8_HORSE Unreviewed; 430 AA.
AC F6YXZ8;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 27-JUL-2011, sequence version 1.
DT 06-MAR-2013, entry version 13.
DE RecName: Full=Aspartate aminotransferase;
DE EC=2.6.1.1;
GN Name=GOT2;
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred;
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H.,
RA Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N.,
RA Penedo M.C.T., Raison J.M., Sharpe T., Vogel J., Andersson L.,
RA Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J.,
RA Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J.,
RA Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R.,
RA Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F.,
RA Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L.,
RA Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M.,
RA White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2]
RP IDENTIFICATION.
RC STRAIN=Thoroughbred;
RG Ensembl;
RL Submitted (JUL-2011) to UniProtKB.
CC -!- CATALYTIC ACTIVITY: L-aspartate + 2-oxoglutarate = oxaloacetate +
CC L-glutamate.
CC -!- COFACTOR: Pyridoxal phosphate (By similarity).
CC -!- SUBUNIT: Homodimer (By similarity).
CC -!- MISCELLANEOUS: In eukaryotes there are cytoplasmic, mitochondrial
CC and chloroplastic isozymes (By similarity).
CC -!- SIMILARITY: Belongs to the class-I pyridoxal-phosphate-dependent
CC aminotransferase family.
CC -!- CAUTION: The sequence shown here is derived from an Ensembl
CC automatic analysis pipeline and should be considered as
CC preliminary data.
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DR RefSeq; XP_001495474.1; XM_001495424.3.
DR Ensembl; ENSECAT00000017874; ENSECAP00000014550; ENSECAG00000016504.
DR GeneID; 100052607; -.
DR KEGG; ecb:100052607; -.
DR GeneTree; ENSGT00390000014081; -.
DR KO; K14455; -.
DR OMA; DFTGAIE; -.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:Compara.
DR GO; GO:0005886; C:plasma membrane; IEA:Compara.
DR GO; GO:0004069; F:L-aspartate:2-oxoglutarate aminotransferase activity; IEA:EC.
DR GO; GO:0080130; F:L-phenylalanine:2-oxoglutarate aminotransferase activity; IEA:EC.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR GO; GO:0006532; P:aspartate biosynthetic process; IEA:Compara.
DR GO; GO:0006533; P:aspartate catabolic process; IEA:Compara.
DR GO; GO:0015908; P:fatty acid transport; IEA:Compara.
DR GO; GO:0019551; P:glutamate catabolic process to 2-oxoglutarate; IEA:Compara.
DR GO; GO:0019550; P:glutamate catabolic process to aspartate; IEA:Compara.
DR GO; GO:0006107; P:oxaloacetate metabolic process; IEA:Compara.
DR GO; GO:0045471; P:response to ethanol; IEA:Compara.
DR Gene3D; 3.40.640.10; -; 1.
DR InterPro; IPR004839; Aminotransferase_I/II.
DR InterPro; IPR000796; Asp_trans.
DR InterPro; IPR004838; NHTrfase_class1_PyrdxlP-BS.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major_sub1.
DR PANTHER; PTHR11879; PTHR11879; 1.
DR Pfam; PF00155; Aminotran_1_2; 1.
DR PRINTS; PR00799; TRANSAMINASE.
DR SUPFAM; SSF53383; PyrdxlP-dep_Trfase_major; 1.
DR PROSITE; PS00105; AA_TRANSFER_CLASS_1; 1.
PE 3: Inferred from homology;
KW Aminotransferase; Complete proteome; Pyridoxal phosphate;
KW Reference proteome; Transferase.
SQ SEQUENCE 430 AA; 47340 MW; 36DC576F320722DA CRC64;
MALLHSGRVL SGVASAFHPG LAAAASARAS SWWAHVEMGP PDPILGVTEA YKRDTNSKKM
NLGVGAYRDD NGKPYVLPSV RKAEAQIAAK NLDKEYLPIG GLAEFCKASA ELALGENSEA
LKSGRYVTVQ SISGTGALRI GANFLQRFFK FSRDVFLPKP SWGNHTPIFR DAGLQLHAYR
YYDPKTCGFD VTGALEDISK IPQQSIILLH ACAHNPTGVD PRPEQWKEIA TLVKKNNLFA
FFDMAYQGFA SGDGDKDAWA VRYFIEQGIN VCLCQSYAKN MGLYGERVGA FTMVCKDADE
AKRVESQLKI LIRPLYSNPP LNGARIASTI LTSPDLRKQW LQEVKGMADR IISMRTQLVS
NLKKEGSSHS WQHIADQIGM FCFTGLKPEQ VERLTKEFSI YMTKDGRISV AGVTSGNVGY
LAHAIHQVTK
//
