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Database: UniProt/TrEMBL
Entry: F6ZZS9_HORSE
LinkDB: F6ZZS9_HORSE
Original site: F6ZZS9_HORSE 
ID   F6ZZS9_HORSE            Unreviewed;       379 AA.
AC   F6ZZS9;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   25-OCT-2017, entry version 34.
DE   SubName: Full=Neuraminidase 2 {ECO:0000313|Ensembl:ENSECAP00000016487};
GN   Name=NEU2 {ECO:0000313|Ensembl:ENSECAP00000016487};
OS   Equus caballus (Horse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000016487, ECO:0000313|Proteomes:UP000002281};
RN   [1] {ECO:0000313|Ensembl:ENSECAP00000016487, ECO:0000313|Proteomes:UP000002281}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000016487,
RC   ECO:0000313|Proteomes:UP000002281};
RX   PubMed=19892987; DOI=10.1126/science.1178158;
RG   Broad Institute Genome Sequencing Platform;
RG   Broad Institute Whole Genome Assembly Team;
RA   Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA   Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H.,
RA   Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N.,
RA   Penedo M.C.T., Raison J.M., Sharpe T., Vogel J., Andersson L.,
RA   Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J.,
RA   Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J.,
RA   Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R.,
RA   Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F.,
RA   Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L.,
RA   Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M.,
RA   White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT   "Genome sequence, comparative analysis, and population genetics of the
RT   domestic horse.";
RL   Science 326:865-867(2009).
RN   [2] {ECO:0000313|Ensembl:ENSECAP00000016487}
RP   IDENTIFICATION.
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000016487};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSECAP00000016487}.
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DR   RefSeq; XP_001499172.1; XM_001499122.3.
DR   STRING; 9796.ENSECAP00000016487; -.
DR   PaxDb; F6ZZS9; -.
DR   Ensembl; ENSECAT00000020102; ENSECAP00000016487; ENSECAG00000018974.
DR   GeneID; 100057378; -.
DR   KEGG; ecb:100057378; -.
DR   CTD; 4759; -.
DR   eggNOG; ENOG410IFVF; Eukaryota.
DR   eggNOG; ENOG410Y74Z; LUCA.
DR   GeneTree; ENSGT00390000011171; -.
DR   InParanoid; F6ZZS9; -.
DR   KO; K12357; -.
DR   OMA; QDTLECQ; -.
DR   OrthoDB; EOG091G08BI; -.
DR   TreeFam; TF331063; -.
DR   Proteomes; UP000002281; Chromosome 6.
DR   GO; GO:1902494; C:catalytic complex; IEA:Ensembl.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0052794; F:exo-alpha-(2->3)-sialidase activity; IEA:Ensembl.
DR   GO; GO:0004308; F:exo-alpha-sialidase activity; IBA:GO_Central.
DR   GO; GO:0051692; P:cellular oligosaccharide catabolic process; IEA:Ensembl.
DR   GO; GO:0006689; P:ganglioside catabolic process; IBA:GO_Central.
DR   GO; GO:0009313; P:oligosaccharide catabolic process; IBA:GO_Central.
DR   InterPro; IPR011040; Sialidase.
DR   InterPro; IPR026945; Sialidase-2.
DR   InterPro; IPR026856; Sialidase_fam.
DR   InterPro; IPR036278; Sialidase_sf.
DR   PANTHER; PTHR10628; PTHR10628; 1.
DR   PANTHER; PTHR10628:SF6; PTHR10628:SF6; 1.
DR   Pfam; PF13088; BNR_2; 1.
DR   SUPFAM; SSF50939; SSF50939; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002281};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT   DOMAIN       33    342       Sialidase. {ECO:0000259|Pfam:PF13088}.
SQ   SEQUENCE   379 AA;  42674 MW;  1AD774EA4C344421 CRC64;
     MASCPILQKE KVFQSGAHAY RIPALLYLPQ QKTLLAFAEK RRDKRDEHAE LIALRKGSYD
     VATHRVLWHA EEVVTQAQLE GHRSMNPSPL YDKKTGTLFL FFISIPGQVS ERHQLHTRVN
     VTRLCQVTST DHGRSWSPAR DVTDSIIGSA YKEWATFALG PGHCLQLHNE SQSLVVPAYA
     YRNLHPRHRP APFAVCFISH DHGHTWQRGN FVAQDTLECQ VAEVGSTKQR VVYLNARSPL
     RARVQAESNN DGLDFKEIQL VTKLAEPPQG CQGSIVSFPN PTVQSDFSDK WLLYTHPTDS
     RQRSNLGVYL NKWPLAPTAW SEPTLLAKGS CAYSDLQSMG AGPDGSPQFA CLYESNNYEE
     IIFLMFTLKQ AFPAEFLPQ
//
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