ID   F7C7S3_MACMU            Unreviewed;       652 AA.
AC   F7C7S3;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   11-DEC-2019, sequence version 2.
DT   27-MAR-2024, entry version 71.
DE   SubName: Full=Histone deacetylase 10 {ECO:0000313|Ensembl:ENSMMUP00000018538.3};
GN   Name=HDAC10 {ECO:0000313|Ensembl:ENSMMUP00000018538.3,
GN   ECO:0000313|VGNC:VGNC:73189};
OS   Macaca mulatta (Rhesus macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000018538.3, ECO:0000313|Proteomes:UP000006718};
RN   [1] {ECO:0000313|Proteomes:UP000006718}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=17573 {ECO:0000313|Proteomes:UP000006718};
RX   PubMed=17431167; DOI=10.1126/science.1139247;
RA   Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA   Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., Wilson R.K.,
RA   Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., Hardison R.C.,
RA   Makova K.D., Miller W., Milosavljevic A., Palermo R.E., Siepel A.,
RA   Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA   Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., Dinh H.H.,
RA   Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., Godfrey J.,
RA   Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N.,
RA   Joshi V., Khan Z.M., Kirkness E.F., Cree A., Fowler R.G., Lee S.,
RA   Lewis L.R., Li Z., Liu Y.-S., Moore S.M., Muzny D., Nazareth L.V.,
RA   Ngo D.N., Okwuonu G.O., Pai G., Parker D., Paul H.A., Pfannkoch C.,
RA   Pohl C.S., Rogers Y.-H.C., Ruiz S.J., Sabo A., Santibanez J.,
RA   Schneider B.W., Smith S.M., Sodergren E., Svatek A.F., Utterback T.R.,
RA   Vattathil S., Warren W., White C.S., Chinwalla A.T., Feng Y., Halpern A.L.,
RA   Hillier L.W., Huang X., Minx P., Nelson J.O., Pepin K.H., Qin X.,
RA   Sutton G.G., Venter E., Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P.,
RA   Jones S.M., Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L.,
RA   Csuros M., Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H.,
RA   Liu Y., Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA   Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA   Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA   Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA   Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., Denby A.,
RA   Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., Marklein A.,
RA   Nielsen R., Vallender E.J., Clark A.G., Ferguson B., Hernandez R.D.,
RA   Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., Pu L.-L., Ren Y.,
RA   Smith D.G., Wheeler D.A., Schenck I., Ball E.V., Chen R., Cooper D.N.,
RA   Giardine B., Hsu F., Kent W.J., Lesk A., Nelson D.L., O'brien W.E.,
RA   Pruefer K., Stenson P.D., Wallace J.C., Ke H., Liu X.-M., Wang P.,
RA   Xiang A.P., Yang F., Barber G.P., Haussler D., Karolchik D., Kern A.D.,
RA   Kuhn R.M., Smith K.E., Zwieg A.S.;
RT   "Evolutionary and biomedical insights from the rhesus macaque genome.";
RL   Science 316:222-234(2007).
RN   [2] {ECO:0000313|Ensembl:ENSMMUP00000018538.3}
RP   IDENTIFICATION.
RC   STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000018538.3};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR   AlphaFoldDB; F7C7S3; -.
DR   SMR; F7C7S3; -.
DR   Ensembl; ENSMMUT00000019803.4; ENSMMUP00000018538.3; ENSMMUG00000014101.4.
DR   VEuPathDB; HostDB:ENSMMUG00000014101; -.
DR   VGNC; VGNC:73189; HDAC10.
DR   eggNOG; KOG1343; Eukaryota.
DR   GeneTree; ENSGT00940000160061; -.
DR   TreeFam; TF106173; -.
DR   Proteomes; UP000006718; Chromosome 10.
DR   Bgee; ENSMMUG00000014101; Expressed in ileum and 19 other cell types or tissues.
DR   ExpressionAtlas; F7C7S3; baseline.
DR   GO; GO:0019899; F:enzyme binding; IEA:UniProt.
DR   GO; GO:0033558; F:protein lysine deacetylase activity; IEA:UniProt.
DR   GO; GO:0010558; P:negative regulation of macromolecule biosynthetic process; IEA:UniProt.
DR   Gene3D; 3.40.800.20; Histone deacetylase domain; 1.
DR   InterPro; IPR000286; His_deacetylse.
DR   InterPro; IPR023801; His_deacetylse_dom.
DR   InterPro; IPR037138; His_deacetylse_dom_sf.
DR   InterPro; IPR023696; Ureohydrolase_dom_sf.
DR   PANTHER; PTHR10625; HISTONE DEACETYLASE HDAC1-RELATED; 1.
DR   PANTHER; PTHR10625:SF18; POLYAMINE DEACETYLASE HDAC10; 1.
DR   Pfam; PF00850; Hist_deacetyl; 1.
DR   PRINTS; PR01270; HDASUPER.
DR   SUPFAM; SSF52768; Arginase/deacetylase; 2.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000006718}.
FT   DOMAIN          20..276
FT                   /note="Histone deacetylase"
FT                   /evidence="ECO:0000259|Pfam:PF00850"
FT   REGION          344..367
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        352..367
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   652 AA;  69215 MW;  4527A9B761689C5D CRC64;
     MGTALVYHED MTATRLLWDD PEYVSLVRKT QVLGEEELQA LSGQFDAIYF HPSTFHCARL
     AAGAGLQLVD AVLTGAVQNG LALVRPPGHH SQRAAANGFC VFNNVAIAAA HAKQKHGLHR
     ILIVDWDVHH GQGIQYLFED DPSVLYFSWH RYEHGRFWPF LRESDADAVG RGQGLGFTVN
     LPWNQVGMGN ADYVAAFLHL LLPLAFEFDP ELVLVSAGFD SAIGDPEGQM QATPECFAHL
     THLLQVLAGG RVCAMLEGGY HLESLAESVC MTVQALLGDP APPLSGLMVP CQSALESIQS
     ARAAQAPYWK SLQLQGQCGQ VLGCRIPPQA PCSGYDSELS LDVTPVPTSP STHSPEGRPP
     PLLPGGPMCK AAAPAPAPSS LLDQLCLCPA PSVRTTVALT APDITLVLPP DVIQQEGSAL
     REETEAWARP HESLAREEAL TALGKLLYLL DGMLDGQVNS GIAATPASAA AATLDVAIQR
     GLSHGAQRLL CVALGQLDRP PDLAHDGRTL WLNIGGKEAA ALSMFHVATP LPVMTGGFLS
     CILGLVLPLA YGFQPDLVLV ALGPGHGLQG PHAALLAAML RGLAGGRVLA LLEEDSTPQL
     AGILARVLRG EAPPSLGPSS VASPEDVQAL MYLRGQLEPQ WKMLQCRPHL VV
//

ID   F7C7T0_MACMU            Unreviewed;       603 AA.
AC   F7C7T0;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   11-DEC-2019, sequence version 3.
DT   27-MAR-2024, entry version 69.
DE   SubName: Full=Histone deacetylase 10 {ECO:0000313|Ensembl:ENSMMUP00000018537.4};
GN   Name=HDAC10 {ECO:0000313|Ensembl:ENSMMUP00000018537.4,
GN   ECO:0000313|VGNC:VGNC:73189};
OS   Macaca mulatta (Rhesus macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000018537.4, ECO:0000313|Proteomes:UP000006718};
RN   [1] {ECO:0000313|Proteomes:UP000006718}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=17573 {ECO:0000313|Proteomes:UP000006718};
RX   PubMed=17431167; DOI=10.1126/science.1139247;
RA   Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA   Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., Wilson R.K.,
RA   Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., Hardison R.C.,
RA   Makova K.D., Miller W., Milosavljevic A., Palermo R.E., Siepel A.,
RA   Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA   Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., Dinh H.H.,
RA   Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., Godfrey J.,
RA   Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N.,
RA   Joshi V., Khan Z.M., Kirkness E.F., Cree A., Fowler R.G., Lee S.,
RA   Lewis L.R., Li Z., Liu Y.-S., Moore S.M., Muzny D., Nazareth L.V.,
RA   Ngo D.N., Okwuonu G.O., Pai G., Parker D., Paul H.A., Pfannkoch C.,
RA   Pohl C.S., Rogers Y.-H.C., Ruiz S.J., Sabo A., Santibanez J.,
RA   Schneider B.W., Smith S.M., Sodergren E., Svatek A.F., Utterback T.R.,
RA   Vattathil S., Warren W., White C.S., Chinwalla A.T., Feng Y., Halpern A.L.,
RA   Hillier L.W., Huang X., Minx P., Nelson J.O., Pepin K.H., Qin X.,
RA   Sutton G.G., Venter E., Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P.,
RA   Jones S.M., Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L.,
RA   Csuros M., Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H.,
RA   Liu Y., Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA   Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA   Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA   Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA   Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., Denby A.,
RA   Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., Marklein A.,
RA   Nielsen R., Vallender E.J., Clark A.G., Ferguson B., Hernandez R.D.,
RA   Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., Pu L.-L., Ren Y.,
RA   Smith D.G., Wheeler D.A., Schenck I., Ball E.V., Chen R., Cooper D.N.,
RA   Giardine B., Hsu F., Kent W.J., Lesk A., Nelson D.L., O'brien W.E.,
RA   Pruefer K., Stenson P.D., Wallace J.C., Ke H., Liu X.-M., Wang P.,
RA   Xiang A.P., Yang F., Barber G.P., Haussler D., Karolchik D., Kern A.D.,
RA   Kuhn R.M., Smith K.E., Zwieg A.S.;
RT   "Evolutionary and biomedical insights from the rhesus macaque genome.";
RL   Science 316:222-234(2007).
RN   [2] {ECO:0000313|Ensembl:ENSMMUP00000018537.4}
RP   IDENTIFICATION.
RC   STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000018537.4};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; F7C7T0; -.
DR   SMR; F7C7T0; -.
DR   Ensembl; ENSMMUT00000019802.4; ENSMMUP00000018537.4; ENSMMUG00000014101.4.
DR   VEuPathDB; HostDB:ENSMMUG00000014101; -.
DR   VGNC; VGNC:73189; HDAC10.
DR   GeneTree; ENSGT00940000160061; -.
DR   Proteomes; UP000006718; Chromosome 10.
DR   Bgee; ENSMMUG00000014101; Expressed in ileum and 19 other cell types or tissues.
DR   ExpressionAtlas; F7C7T0; baseline.
DR   GO; GO:0019899; F:enzyme binding; IEA:UniProt.
DR   GO; GO:0033558; F:protein lysine deacetylase activity; IEA:UniProt.
DR   GO; GO:0010558; P:negative regulation of macromolecule biosynthetic process; IEA:UniProt.
DR   Gene3D; 3.40.800.20; Histone deacetylase domain; 1.
DR   InterPro; IPR000286; His_deacetylse.
DR   InterPro; IPR023801; His_deacetylse_dom.
DR   InterPro; IPR037138; His_deacetylse_dom_sf.
DR   InterPro; IPR023696; Ureohydrolase_dom_sf.
DR   PANTHER; PTHR10625; HISTONE DEACETYLASE HDAC1-RELATED; 1.
DR   PANTHER; PTHR10625:SF18; POLYAMINE DEACETYLASE HDAC10; 1.
DR   Pfam; PF00850; Hist_deacetyl; 1.
DR   PRINTS; PR01270; HDASUPER.
DR   SUPFAM; SSF52768; Arginase/deacetylase; 2.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000006718}.
FT   DOMAIN          25..188
FT                   /note="Histone deacetylase"
FT                   /evidence="ECO:0000259|Pfam:PF00850"
FT   REGION          295..314
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   603 AA;  64392 MW;  3F8B12E112E212CE CRC64;
     MGTALVYHED MTATRLLWDD PECEIERPER LTAALDRLRQ RGLEQRCLRL SAREASKEEL
     GLVHSPEYVS LVRKTQVLGE EELQALSGQF DAIYFHPSTF HCARLAAGAG LQLVDAVLTG
     AVQNGLALVR PPGHHSQRAA ANGFCVFNNV AIAAAHAKQK HGLHRILIVD WDVHHGQGIQ
     YLFEDDPSSG CSLGCPARSG WETLTTWLPS CTCCSHWPLS LTLSWCWSQQ DLTQPSGTLR
     GKCRPRQSAS PTSHICCRCW PAAGSAPCWS ALESIQSARA AQAPYWKSLQ LQDVTPVPTS
     PSTHSPEGRP PPLLPGGPMC KAAAPAPAPS SLLDQLCLCP APSVRTTVAL TAPDITLVLP
     PDVIQQEGSA LREETEAWAR PHESLAREEA LTALGKLLYL LDGMLDGQVN SGIAATPASA
     AAATLDVAIQ RGLSHGAQRL LCVALGQLDR PPDLAHDGRT LWLNIGGKEA AALSMFHVAT
     PLPVMTGGFL SCILGLVLPL AYGFQPDLVL VALGPGHGLQ GPHAALLAAM LRGLAGGRVL
     ALLEEDSTPQ LAGILARVLR GEAPPSLGPS SVASPEDVQA LMYLRGQLEP QWKMLQCRPH
     LVV
//