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Database: UniProt/TrEMBL
Entry: F7EBE4_CALJA
LinkDB: F7EBE4_CALJA
Original site: F7EBE4_CALJA 
ID   F7EBE4_CALJA            Unreviewed;       752 AA.
AC   F7EBE4;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   25-OCT-2017, entry version 47.
DE   SubName: Full=Neuroendocrine convertase 1 isoform 1 preproprotein {ECO:0000313|EMBL:JAB32070.1};
DE   SubName: Full=Proprotein convertase subtilisin/kexin type 1 {ECO:0000313|Ensembl:ENSCJAP00000018769};
GN   Name=PCSK1 {ECO:0000313|EMBL:JAB32070.1,
GN   ECO:0000313|Ensembl:ENSCJAP00000018769};
OS   Callithrix jacchus (White-tufted-ear marmoset).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Platyrrhini; Cebidae; Callitrichinae; Callithrix; Callithrix.
OX   NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000018769, ECO:0000313|Proteomes:UP000008225};
RN   [1] {ECO:0000313|Ensembl:ENSCJAP00000018769, ECO:0000313|Proteomes:UP000008225}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCJAP00000018769}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUN-2011) to UniProtKB.
RN   [3] {ECO:0000313|EMBL:JAB32070.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Cerebral cortex {ECO:0000313|EMBL:JAB32070.1};
RX   PubMed=25243066; DOI=10.1186/2047-217X-3-14;
RA   Maudhoo M.D., Ren D., Gradnigo J.S., Gibbs R.M., Lubker A.C.,
RA   Moriyama E.N., French J.A., Norgren R.B.Jr.;
RT   "De novo assembly of the common marmoset transcriptome from NextGen
RT   mRNA sequences.";
RL   Gigascience 3:14-14(2014).
CC   -!- SIMILARITY: Belongs to the peptidase S8 family.
CC       {ECO:0000256|RuleBase:RU003355, ECO:0000256|SAAS:SAAS00679558}.
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DR   EMBL; ACFV01007187; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACFV01007188; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; GAMR01001862; JAB32070.1; -; mRNA.
DR   RefSeq; XP_002744800.1; XM_002744754.4.
DR   STRING; 9483.ENSCJAP00000018769; -.
DR   MEROPS; S08.072; -.
DR   Ensembl; ENSCJAT00000019825; ENSCJAP00000018769; ENSCJAG00000010166.
DR   GeneID; 100403507; -.
DR   KEGG; cjc:100403507; -.
DR   CTD; 5122; -.
DR   eggNOG; KOG3525; Eukaryota.
DR   eggNOG; COG1404; LUCA.
DR   eggNOG; COG4935; LUCA.
DR   GeneTree; ENSGT00750000117358; -.
DR   KO; K01359; -.
DR   OMA; FEPRALK; -.
DR   OrthoDB; EOG091G05HI; -.
DR   TreeFam; TF314277; -.
DR   Proteomes; UP000008225; Chromosome 2.
DR   GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:Ensembl.
DR   GO; GO:0043043; P:peptide biosynthetic process; IEA:Ensembl.
DR   GO; GO:0016486; P:peptide hormone processing; IEA:Ensembl.
DR   CDD; cd04059; Peptidases_S8_Protein_converta; 1.
DR   Gene3D; 2.60.120.260; -; 1.
DR   Gene3D; 3.40.50.200; -; 1.
DR   InterPro; IPR008979; Galactose-bd-like.
DR   InterPro; IPR034182; Kexin/furin.
DR   InterPro; IPR009020; Peptidase/Inhibitor_I9.
DR   InterPro; IPR000209; Peptidase_S8/S53_dom.
DR   InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR   InterPro; IPR023827; Peptidase_S8_Asp-AS.
DR   InterPro; IPR022398; Peptidase_S8_His-AS.
DR   InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR   InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR   InterPro; IPR022005; Proho_convert.
DR   InterPro; IPR002884; PrprotnconvertsP.
DR   InterPro; IPR032815; S8_pro-domain.
DR   Pfam; PF01483; P_proprotein; 1.
DR   Pfam; PF00082; Peptidase_S8; 1.
DR   Pfam; PF12177; Proho_convert; 1.
DR   Pfam; PF16470; S8_pro-domain; 1.
DR   PRINTS; PR00723; SUBTILISIN.
DR   SUPFAM; SSF49785; SSF49785; 1.
DR   SUPFAM; SSF52743; SSF52743; 1.
DR   SUPFAM; SSF54897; SSF54897; 1.
DR   PROSITE; PS00136; SUBTILASE_ASP; 1.
DR   PROSITE; PS00137; SUBTILASE_HIS; 1.
DR   PROSITE; PS00138; SUBTILASE_SER; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000008225};
KW   Hydrolase {ECO:0000256|RuleBase:RU003355,
KW   ECO:0000256|SAAS:SAAS00912743};
KW   Protease {ECO:0000256|RuleBase:RU003355,
KW   ECO:0000256|SAAS:SAAS00912730};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008225};
KW   Serine protease {ECO:0000256|RuleBase:RU003355,
KW   ECO:0000256|SAAS:SAAS00912691}; Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     27       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        28    752       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5010832756.
FT   DOMAIN       34    110       S8_pro-domain. {ECO:0000259|Pfam:
FT                                PF16470}.
FT   DOMAIN      158    442       Peptidase S8. {ECO:0000259|Pfam:PF00082}.
FT   DOMAIN      504    591       P_proprotein. {ECO:0000259|Pfam:PF01483}.
FT   DOMAIN      713    750       Proho_convert. {ECO:0000259|Pfam:
FT                                PF12177}.
SQ   SEQUENCE   752 AA;  83986 MW;  CF5C253D790C13BE CRC64;
     MERRAWTLQC TAFALFCAWC ALNSAKAKRQ FVNEWAAEIP GGPEAASAIA EELGYDLLGQ
     IGSLENHYLF KHKNHPRRSR RSALHITKRL SDDDRVIWAE QQYEKERNKR SALRDSAVNL
     FNDPMWNQQW YLQDTRMTAA LPKLDLHVIP VWQKGITGKG VVITVLDDGL EWNHTDIYAN
     YDPDASYDFN DNDHDPFPRY DPTNENKHGT RCAGEIAMQA NNHKCGVGVA YNSKVGGIRM
     LDGIVTDAIE ASSIGFNPGH VDIYSASWGP NDDGKTVEGP GRLAQKAFEY GVKQGRQGKG
     SIFVWASGNG GRQGDNCDCD GYTDSIYTIS ISSASQQGLS PWYAEKCSST LATSYSSGDY
     TDQRITSADL HNDCTETHTG TSASAPLAAG IFALALEANP NLTWRDMQHL VVWTSEYDPL
     ANNPGWKKNG AGLMVNSRFG FGLLNAKALV DLADPRTWRS VPEKKECVVK DNDFQPRALK
     ANGEVIIEIP TRACDGQENA INSLEHVQFE ATIEYSRRGD LHVTLTSAAG TSTVLLAERE
     RDTSPNGFKN WDFMSVHTWG ENPIGTWTLR ITDMSGRIQN EGRIVNWKLI LHGTSSQPEH
     MKQPRVYTSY NTVQNDRRGV EKMVDPEEEQ PTQENPKENP VVSKSPSSSV GGQRDKLEEG
     APSEAMLRLL QSAFSKNSSP KQSPKKSPSA KPNIPYENFY EALEKLNKPS QLKDSEDSLY
     NDYVDVFYNT KPYKHRDDRL LQALVDILNE EN
//
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