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Database: UniProt/TrEMBL
Entry: F7I5R7_CALJA
LinkDB: F7I5R7_CALJA
Original site: F7I5R7_CALJA 
ID   F7I5R7_CALJA            Unreviewed;       638 AA.
AC   F7I5R7;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   30-AUG-2017, entry version 46.
DE   SubName: Full=Neuroendocrine convertase 2 isoform 1 preproprotein {ECO:0000313|EMBL:JAB18355.1};
DE   SubName: Full=Proprotein convertase subtilisin/kexin type 2 {ECO:0000313|Ensembl:ENSCJAP00000008908};
GN   Name=PCSK2 {ECO:0000313|EMBL:JAB18355.1,
GN   ECO:0000313|Ensembl:ENSCJAP00000008908};
OS   Callithrix jacchus (White-tufted-ear marmoset).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Platyrrhini; Cebidae; Callitrichinae; Callithrix; Callithrix.
OX   NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000008908, ECO:0000313|Proteomes:UP000008225};
RN   [1] {ECO:0000313|Ensembl:ENSCJAP00000008908, ECO:0000313|Proteomes:UP000008225}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCJAP00000008908}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
RN   [3] {ECO:0000313|EMBL:JAB18355.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Cerebellum {ECO:0000313|EMBL:JAB45394.1}, Cerebral cortex
RC   {ECO:0000313|EMBL:JAB32515.1}, and Hippocampus
RC   {ECO:0000313|EMBL:JAB18355.1};
RX   PubMed=25243066; DOI=10.1186/2047-217X-3-14;
RA   Maudhoo M.D., Ren D., Gradnigo J.S., Gibbs R.M., Lubker A.C.,
RA   Moriyama E.N., French J.A., Norgren R.B.Jr.;
RT   "De novo assembly of the common marmoset transcriptome from NextGen
RT   mRNA sequences.";
RL   Gigascience 3:14-14(2014).
CC   -!- SIMILARITY: Belongs to the peptidase S8 family.
CC       {ECO:0000256|RuleBase:RU003355, ECO:0000256|SAAS:SAAS00679558}.
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DR   EMBL; ACFV01050228; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACFV01050229; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACFV01050230; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACFV01050231; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACFV01050232; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACFV01050233; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACFV01050234; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACFV01050235; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; GAMS01004781; JAB18355.1; -; mRNA.
DR   EMBL; GAMR01001417; JAB32515.1; -; mRNA.
DR   EMBL; GAMP01007361; JAB45394.1; -; mRNA.
DR   RefSeq; XP_002747512.1; XM_002747466.2.
DR   STRING; 9483.ENSCJAP00000008908; -.
DR   MEROPS; S08.073; -.
DR   Ensembl; ENSCJAT00000009413; ENSCJAP00000008908; ENSCJAG00000004853.
DR   GeneID; 100410189; -.
DR   KEGG; cjc:100410189; -.
DR   CTD; 5126; -.
DR   eggNOG; KOG3525; Eukaryota.
DR   eggNOG; KOG3526; Eukaryota.
DR   eggNOG; COG1404; LUCA.
DR   eggNOG; COG4935; LUCA.
DR   GeneTree; ENSGT00750000117358; -.
DR   KO; K01360; -.
DR   OMA; PQRGVLK; -.
DR   OrthoDB; EOG091G05HI; -.
DR   TreeFam; TF314277; -.
DR   Proteomes; UP000008225; Chromosome 5.
DR   GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR   GO; GO:0016020; C:membrane; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:Ensembl.
DR   GO; GO:0034230; P:enkephalin processing; IEA:Ensembl.
DR   GO; GO:0030070; P:insulin processing; IEA:Ensembl.
DR   GO; GO:0007399; P:nervous system development; IEA:Ensembl.
DR   GO; GO:0016540; P:protein autoprocessing; IEA:Ensembl.
DR   CDD; cd04059; Peptidases_S8_Protein_converta; 1.
DR   Gene3D; 2.60.120.260; -; 1.
DR   Gene3D; 3.40.50.200; -; 1.
DR   InterPro; IPR008979; Galactose-bd-like.
DR   InterPro; IPR034182; Kexin/furin.
DR   InterPro; IPR009020; Peptidase/Inhibitor_I9.
DR   InterPro; IPR000209; Peptidase_S8/S53_dom.
DR   InterPro; IPR023827; Peptidase_S8_Asp-AS.
DR   InterPro; IPR022398; Peptidase_S8_His-AS.
DR   InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR   InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR   InterPro; IPR002884; PrprotnconvertsP.
DR   InterPro; IPR032815; S8_pro-domain.
DR   Pfam; PF01483; P_proprotein; 1.
DR   Pfam; PF00082; Peptidase_S8; 1.
DR   Pfam; PF16470; S8_pro-domain; 1.
DR   PRINTS; PR00723; SUBTILISIN.
DR   SUPFAM; SSF49785; SSF49785; 1.
DR   SUPFAM; SSF52743; SSF52743; 1.
DR   SUPFAM; SSF54897; SSF54897; 1.
DR   PROSITE; PS00136; SUBTILASE_ASP; 1.
DR   PROSITE; PS00137; SUBTILASE_HIS; 1.
DR   PROSITE; PS00138; SUBTILASE_SER; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000008225};
KW   Hydrolase {ECO:0000256|RuleBase:RU003355,
KW   ECO:0000256|SAAS:SAAS00066207};
KW   Protease {ECO:0000256|RuleBase:RU003355,
KW   ECO:0000256|SAAS:SAAS00066236};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008225};
KW   Serine protease {ECO:0000256|RuleBase:RU003355,
KW   ECO:0000256|SAAS:SAAS00066164}.
FT   DOMAIN       33    109       S8_pro-domain. {ECO:0000259|Pfam:
FT                                PF16470}.
FT   DOMAIN      158    420       Peptidase S8. {ECO:0000259|Pfam:PF00082}.
FT   DOMAIN      504    590       P_proprotein. {ECO:0000259|Pfam:PF01483}.
SQ   SEQUENCE   638 AA;  70373 MW;  A1417EAC4A17D2B4 CRC64;
     MKGGCVSQWK AAAGFLFCVM VFASAELPVF TNHFLVELHK GGEEEARQVA AEHGFGVRKL
     PFAEGLYHFY HNGLAKAKKR LSLHHKQQLE RDPRVKVALQ QEGFDRKKRG YRDLNAIDMN
     MNDPLFTKQW YLINTGQADG TPGLDLNVAE AWELGYTGKG VTIGIMDDGI DYLHPDLASN
     YNAEASYDFS SNDPYPYPRY TDDWFNSHGT RCAGEVSAAA NNNICGVGVA YNSKVAGIRM
     LDQPFMTDII EASSISHMPQ LIDIYSASWG PTDNGKTVDG PRELTLQAMA DGVNKGRGGK
     GSIYVWASGD GGSYDDCNCD GYASSMWTIS INSAINDGRT ALYDESCSST LASTFSNGRK
     RNPEAGVATT DLYGNCTLRH SGTSAAAPEA AGVFALALEA NLGLTWRDMQ HLTVLTSKRN
     QLHDEVHQWR RNGVGLEFNH LFGYGVLDAG AMVKMAKDWK TVPERFHCVG GSAQDPEKIP
     STGKLVLTLT TDACEGKENF VRYLEHVQAV ITVNATRRGD LNINMTSPMG TKSILLSRRP
     RDDDSKVGFD KWPFMTTHTW GEDARGTWTL ELGFVGSTPQ KGVLKEWTLM LHGTQSAPYI
     DQVVRDYQSK LAMSKKEELE EELDEAVERS LKSIFGKN
//
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