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Database: UniProt/TrEMBL
Entry: F7VK39_SORMK
LinkDB: F7VK39_SORMK
Original site: F7VK39_SORMK 
ID   F7VK39_SORMK            Unreviewed;      1825 AA.
AC   F7VK39;
DT   21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT   21-SEP-2011, sequence version 1.
DT   25-OCT-2017, entry version 36.
DE   RecName: Full=DNA ligase {ECO:0000256|RuleBase:RU000617};
DE            EC=6.5.1.1 {ECO:0000256|RuleBase:RU000617};
GN   ORFNames=SMAC_00082 {ECO:0000313|EMBL:CCC05866.1};
OS   Sordaria macrospora (strain ATCC MYA-333 / DSM 997 / K(L3346) /
OS   K-hell).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
OC   Sordariomycetes; Sordariomycetidae; Sordariales; Sordariaceae;
OC   Sordaria.
OX   NCBI_TaxID=771870 {ECO:0000313|EMBL:CCC05866.1, ECO:0000313|Proteomes:UP000001881};
RN   [1] {ECO:0000313|EMBL:CCC05866.1, ECO:0000313|Proteomes:UP000001881}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-333 / DSM 997 / K(L3346) / K-hell
RC   {ECO:0000313|Proteomes:UP000001881};
RC   TISSUE=Mycelium {ECO:0000313|EMBL:CCC05866.1};
RX   PubMed=20386741; DOI=10.1371/journal.pgen.1000891;
RA   Nowrousian M., Stajich J., Chu M., Engh I., Espagne E., Halliday K.,
RA   Kamerewerd J., Kempken F., Knab B., Kuo H.C., Osiewacz H.D.,
RA   Poeggeler S., Read N., Seiler S., Smith K., Zickler D., Kueck U.,
RA   Freitag M.;
RT   "De novo assembly of a 40 Mb eukaryotic genome from short sequence
RT   reads: Sordaria macrospora, a model organism for fungal
RT   morphogenesis.";
RL   PLoS Genet. 6:E1000891-E1000891(2010).
CC   -!- CATALYTIC ACTIVITY: ATP + (deoxyribonucleotide)(n)-3'-hydroxyl +
CC       5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) +
CC       AMP + diphosphate. {ECO:0000256|RuleBase:RU000617}.
CC   -!- SIMILARITY: Belongs to the ATP-dependent DNA ligase family.
CC       {ECO:0000256|RuleBase:RU004196}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:CCC05866.1}.
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DR   EMBL; CABT02000001; CCC05866.1; -; Genomic_DNA.
DR   RefSeq; XP_003351540.1; XM_003351492.1.
DR   STRING; 771870.XP_003351540.1; -.
DR   EnsemblFungi; CCC05866; CCC05866; SMAC_00082.
DR   GeneID; 10809135; -.
DR   KEGG; smp:SMAC_00082; -.
DR   EuPathDB; FungiDB:SMAC_00082; -.
DR   eggNOG; KOG0966; Eukaryota.
DR   eggNOG; COG1793; LUCA.
DR   InParanoid; F7VK39; -.
DR   KO; K10777; -.
DR   OrthoDB; EOG092C0XHN; -.
DR   Proteomes; UP000001881; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:UniProtKB-EC.
DR   GO; GO:0071897; P:DNA biosynthetic process; IEA:InterPro.
DR   GO; GO:0051103; P:DNA ligation involved in DNA repair; IEA:InterPro.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   CDD; cd00027; BRCT; 1.
DR   Gene3D; 1.10.3260.10; -; 1.
DR   Gene3D; 3.40.50.10190; -; 1.
DR   InterPro; IPR001357; BRCT_dom.
DR   InterPro; IPR036420; BRCT_dom_sf.
DR   InterPro; IPR000977; DNA_ligase_ATP-dep.
DR   InterPro; IPR012309; DNA_ligase_ATP-dep_C.
DR   InterPro; IPR012310; DNA_ligase_ATP-dep_cent.
DR   InterPro; IPR016059; DNA_ligase_ATP-dep_CS.
DR   InterPro; IPR012308; DNA_ligase_ATP-dep_N.
DR   InterPro; IPR036599; DNA_ligase_N_sf.
DR   InterPro; IPR027842; DUF4449.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   Pfam; PF04679; DNA_ligase_A_C; 1.
DR   Pfam; PF01068; DNA_ligase_A_M; 1.
DR   Pfam; PF04675; DNA_ligase_A_N; 1.
DR   Pfam; PF14613; DUF4449; 1.
DR   SUPFAM; SSF117018; SSF117018; 1.
DR   SUPFAM; SSF50249; SSF50249; 1.
DR   SUPFAM; SSF52113; SSF52113; 1.
DR   TIGRFAMs; TIGR00574; dnl1; 1.
DR   PROSITE; PS50172; BRCT; 1.
DR   PROSITE; PS00697; DNA_LIGASE_A1; 1.
DR   PROSITE; PS50160; DNA_LIGASE_A3; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|RuleBase:RU000617};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001881};
KW   DNA damage {ECO:0000256|RuleBase:RU000617};
KW   DNA recombination {ECO:0000256|RuleBase:RU000617};
KW   DNA repair {ECO:0000256|RuleBase:RU000617};
KW   DNA replication {ECO:0000256|RuleBase:RU000617};
KW   Ligase {ECO:0000256|RuleBase:RU000617};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU000617};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001881}.
FT   DOMAIN     1314   1437       DNA_LIGASE_A3. {ECO:0000259|PROSITE:
FT                                PS50160}.
FT   DOMAIN     1620   1719       BRCT. {ECO:0000259|PROSITE:PS50172}.
SQ   SEQUENCE   1825 AA;  205426 MW;  0078FFB56F010D9C CRC64;
     MATVNGKANV NRPVDAKQKE ADVNRKLQFY GIASAFQHGK VPSNDQIDVA LNSFLQSRAL
     ANPSKKLSTE GQALVADFRE VVRQAKNLLL SKNDGNLLQD FIWQTQQWDP KAVNVPGAPV
     NKEQAQQHGN QALEGLRTLG TLIITNGQFR KLLKDATVLL RDIAGDAATN AAARVRPSQE
     DLQQIDAPAA DNTWHEKPEL SRDQVKSKFN DFYKGNPKED AKHIMGEATS AAHPDGSANP
     RDLANTAAHD GRTGGSSGID AQKGVSAAAN TAQQKIDQNL DDETREKAKN KKEEYRARTR
     EYFQKKVPQE RREQTIWRLK KMVVECQQHP DYQRAITTLL NLAEEYGSHA NRLAQGGTGT
     VKETRTALAQ AEGDLKTLIE RFANGTSSDD LWASINTIYE DADRDPELKN WFKAMNSYIR
     RCLREEGYIL DDASNEEWNR LYDHGNYLLR NKYRAHTDRI VDELKFLADQ FDQDPQNQSF
     AASLNKLFAD LGNDENGKPT FKPHLIKDLT DVIIPAMFEN VAYIPVPRIE YSDPQIDAVI
     ENLVLESDNF MPNVLEVASE NYMRFGRKKI ANKNRMAVDV KVAGIQMDLR DVSYYIKRKQ
     GFPSLSDTGI FNILLEGDGF TFRMKMSSAD AKDRQNFFKI DKVDVDVKNL RIKLVKSNHK
     LLFNLFKPIM LKVLRPGLQK ALEKAIRDQA ARLDSMLYEI KQEADRALDE AREDPEKTPN
     IYNRYVTAAQ KKILQGKQKA QGVVADKKVN YAVTKEDSIF PHIHLPGGIS SKATEYKDLA
     RKGDKWESPV FSIGSAGKSH DIPGAPHVVR KPHAASNPHT ASNPHAATNG AAHGSGNGYA
     LHGGPGANVG NGGLNVPGGN YLPSDPAMGG HGMKTVGTAP NGRVAVVHIS MEEADPHHMY
     FQSSPLTRNP SFPNRPHNHS KTFPFSDLYR TLFNPLIDCK PSTSGGGPVR GPKPGRGGHF
     SSTVSYHEQR RHIIERFMSR WRSEVGNDFY PAMRLILPDK DRDRGVYGLK ENSIGRLLVK
     VMKIDRNSED GYNLMHWKLP GQSGISRSVG DFAGRVFEVV SKRAMRSEPG NMTVADVNVL
     LDRLAGASGE AEQMPIFDEF YRQMNAEEVM WLVRIILKDM RVGATERTFL NLWHPDAEAL
     FSVSSSLRRV CWELYDPEFR LEQQETGITL MQCFQSQLAQ FQMTTTFDKL VKNLGVTEEG
     QEFWIEEKLD GERMQMHMME DDTVPGGFRF AFWSRKAKDY TYLYGESLGD EQSALTRHLR
     NAFADGVRNL ILDGEMITWD IDIDKMVPFG TLKTAALEQQ KNPSKAGPRP LYRVFDIMLL
     NDKPLTEYTL NDRRKALERA VVGVHRRLEI LPFERATSPD AIEPLLRRVV AEASEGLVLK
     NPRSRYSLNS RNNDWIKVKP EYMSEFGESM DCVVVGGYFG SGRRGGTLSS FLCGLRVSQN
     LIESGKAATA EKCLSFFKVG GGLKAEDYAE IRHHTEGKWQ DWDAANPPTE YIELGGGERL
     QYEKPDVWIR PSDSVVISVK AASITPTDQF AMGWTLRFPR FRKLRLDRTW DSALDMDEFE
     VLRSKIKDQE QERKKMEMES RKRKPATKRA RKDLVIAGMS NPSLSSSATP FVAPRATREA
     STHLFIGLDF CVLSESLKPN KMAKPALEKL IKDHGGRIYQ QVVDRSGDQE KIIIPIADKN
     VVKVASLKKA HPEMDIIRPK WVFDCLAQPM SRKEKGYLLP FEPIHIFHAG SEQTEQEAEE
     AVDRFGDSYA RDLADIDELK AVMEGMDQSD EYVSDSDWDS DSGSKKNRGG GFDMNHFLGH
     LEAQGAASLD ELRSFMFRRC RVFLL
//
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