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Database: UniProt/TrEMBL
Entry: F8GRI3_CUPNN
LinkDB: F8GRI3_CUPNN
Original site: F8GRI3_CUPNN 
ID   F8GRI3_CUPNN            Unreviewed;       757 AA.
AC   F8GRI3;
DT   21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT   21-SEP-2011, sequence version 1.
DT   07-JUN-2017, entry version 31.
DE   SubName: Full=Isocitrate dehydrogenase [NADP] {ECO:0000313|EMBL:AEI80848.1};
DE            EC=1.1.1.42 {ECO:0000313|EMBL:AEI80848.1};
GN   Name=icd {ECO:0000313|EMBL:AEI80848.1};
GN   OrderedLocusNames=CNE_2c18920 {ECO:0000313|EMBL:AEI80848.1};
OS   Cupriavidus necator (strain ATCC 43291 / DSM 13513 / N-1) (Ralstonia
OS   eutropha).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Cupriavidus.
OX   NCBI_TaxID=1042878 {ECO:0000313|EMBL:AEI80848.1, ECO:0000313|Proteomes:UP000006798};
RN   [1] {ECO:0000313|EMBL:AEI80848.1, ECO:0000313|Proteomes:UP000006798}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43291 / DSM 13513 / N-1
RC   {ECO:0000313|Proteomes:UP000006798};
RX   PubMed=21742890; DOI=10.1128/JB.05660-11;
RA   Poehlein A., Kusian B., Friedrich B., Daniel R., Bowien B.;
RT   "Complete genome sequence of the type strain Cupriavidus necator N-
RT   1.";
RL   J. Bacteriol. 193:5017-5017(2011).
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Note=Binds 1 Mg(2+) or Mn(2+) ion per subunit.
CC       {ECO:0000256|PIRSR:PIRSR009407-3};
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DR   EMBL; CP002878; AEI80848.1; -; Genomic_DNA.
DR   ProteinModelPortal; F8GRI3; -.
DR   EnsemblBacteria; AEI80848; AEI80848; CNE_2c18920.
DR   KEGG; cnc:CNE_2c18920; -.
DR   KO; K00031; -.
DR   OMA; RDSGKMW; -.
DR   OrthoDB; POG091H0B3N; -.
DR   Proteomes; UP000006798; Chromosome 2.
DR   GO; GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR   InterPro; IPR004436; Isocitrate_DH_NADP_mono.
DR   Pfam; PF03971; IDH; 1.
DR   PIRSF; PIRSF009407; IDH_monmr; 1.
DR   TIGRFAMs; TIGR00178; monomer_idh; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000006798};
KW   Magnesium {ECO:0000256|PIRSR:PIRSR009407-3};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR009407-3};
KW   Oxidoreductase {ECO:0000313|EMBL:AEI80848.1}.
FT   REGION      146    153       Substrate binding. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   METAL       364    364       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       563    563       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       567    567       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   BINDING     159    159       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   BINDING     562    562       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   SITE        269    269       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
FT   SITE        434    434       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
SQ   SEQUENCE   757 AA;  83395 MW;  C7106518F477B486 CRC64;
     MSHHPFEDLR EAMSNQQPTI IYTLTDEAPL LATSAFLPII QTFTKPAGIN VTTSDISVAG
     RILGEFPEFL TEAQRVPDNL AELGKLTQLP DTNIIKLPNI SASVHQLVSA IRELQGKGYK
     VPDYPEDPKT DEEKAIQKRY SKCLGSAVNP VLREGNSDRR APAAVKNFAR KHPHSMGEWS
     MASRTHVAHM KHGDFYHGEK SMTLDKARDV KMELVTKSGK TIVLKPKVSL LDGEIIDSMF
     MSKKALCDFY EEQFEDARKT GVMLSLHVKA TMMKVSHPIV FGHAVKIFYK EAFAKHGALF
     DELGVNVNNG LVNLYEKIEA LPSSKREEII RDLHACHEHR PELAMVDSAK GISNLHAPND
     VIVDASMPAM IRIGGKMWGA DGRPKDTKAV IPESTFARIY QEIINFCKTN GNFDPTTMGT
     VPNVGLMAQK AEEYGSHDKT FEIAEDGVAN IVDLATGEVL LTQDVEQGDI WRMCQVKDAP
     IRDWVKLAVT RARNSGMPAV FWLDPYRPHE AELIKKVEAY LKGYDTTGLD IQIMSQVRAM
     RYTLERVIRG LDTISVTGNI LRDYLTDLFP IMELGTSAKM LSIVPLMAGG GMYETGAGGS
     APKHVKQLVE ENHLRWDSLG EFLALAVSLE DVGIKTGNAR AKILAKTLDA ATGKLLDNNK
     SPSPKTGQLD NRGSQFYLAM YWAQELAVQS DDAELATKFA PLAKTLTDNE QKIVGELGAV
     QGKPVDIGGY YMPEADKLSA AMRPSQTLNA ALSTVTA
//
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