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Database: UniProt/TrEMBL
Entry: F8JJ69_STREN
LinkDB: F8JJ69_STREN
Original site: F8JJ69_STREN 
ID   F8JJ69_STREN            Unreviewed;       739 AA.
AC   F8JJ69; G8XH81;
DT   21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT   21-SEP-2011, sequence version 1.
DT   07-JUN-2017, entry version 47.
DE   SubName: Full=Isocitrate dehydrogenase {ECO:0000313|EMBL:AEW98827.1};
GN   OrderedLocusNames=SCATT_p06340 {ECO:0000313|EMBL:AEW98827.1};
OS   Streptomyces cattleya (strain ATCC 35852 / DSM 46488 / JCM 4925 / NBRC
OS   14057 / NRRL 8057).
OG   Plasmid pSCATT {ECO:0000313|EMBL:AEW98827.1,
OG   ECO:0000313|Proteomes:UP000007842}.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=1003195 {ECO:0000313|EMBL:AEW98827.1, ECO:0000313|Proteomes:UP000007842};
RN   [1] {ECO:0000313|Proteomes:UP000007842}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35852 / DSM 46488 / JCM 4925 / NBRC 14057 / NRRL 8057
RC   {ECO:0000313|Proteomes:UP000007842};
RC   PLASMID=Plasmid pSCATT {ECO:0000313|Proteomes:UP000007842};
RA   Ou H.-Y., Li P., Zhao C., O'Hagan D., Deng Z.;
RT   "Complete genome sequence of Streptomyces cattleya strain DSM 46488.";
RL   Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Note=Binds 1 Mg(2+) or Mn(2+) ion per subunit.
CC       {ECO:0000256|PIRSR:PIRSR009407-3};
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DR   EMBL; CP003229; AEW98827.1; -; Genomic_DNA.
DR   RefSeq; WP_014151550.1; NC_017585.1.
DR   ProteinModelPortal; F8JJ69; -.
DR   EnsemblBacteria; AEW98827; AEW98827; SCATT_p06340.
DR   KEGG; sct:SCAT_p1101; -.
DR   KEGG; scy:SCATT_p06340; -.
DR   PATRIC; fig|1003195.11.peg.1058; -.
DR   KO; K00031; -.
DR   OMA; RDSGKMW; -.
DR   Proteomes; UP000007842; Plasmid pSCATT.
DR   GO; GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR   InterPro; IPR004436; Isocitrate_DH_NADP_mono.
DR   Pfam; PF03971; IDH; 1.
DR   PIRSF; PIRSF009407; IDH_monmr; 1.
DR   TIGRFAMs; TIGR00178; monomer_idh; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000007842};
KW   Magnesium {ECO:0000256|PIRSR:PIRSR009407-3};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR009407-3};
KW   Plasmid {ECO:0000313|EMBL:AEW98827.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007842}.
FT   REGION      132    139       Substrate binding. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   METAL       348    348       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       546    546       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       550    550       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   BINDING     145    145       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   BINDING     545    545       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   SITE        255    255       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
FT   SITE        418    418       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
SQ   SEQUENCE   739 AA;  79673 MW;  7B3C32C5E0D4769C CRC64;
     MTDSTIIYTH TDEAPALATY SFLPVVEAYA SKAGVTVETR DISLAGRILA VFPEYLEEGQ
     RIDDALAELG ELAKTPGANI IKLPNISASI PQLKAAVAEL REQGYALPEY PDDPKTDEER
     EIRARYDKVK GSAVNPVLRE GNSDRRAPAS VKNYAKTHPH RMGAWTADSK TNVAHMTGDD
     FRSTEKSAVV AEAGSLRIEL AGDDGTTTVL RESVPVLAGE VVDASVMRVA ALREFLAAQV
     ARAKAEGVLF SVHLKATMMK VSDPIVFGHV VRAFFPKTFA KYGEVLASAG LTPNDGLGGI
     FKGLEGLPEG AEIKASFDAE LGEGPALAMV DSDRGITNLH VPSDVIVDAS MPAMIRTSGH
     MWGPDGKEAD TLAVLPDSSY AGVYQAVIDD CRANGAFDPA TMGSVPNVGL MAQKAEEYGS
     HDKTFEIPTT GTVRVVDEAG EVVLQQTVSA GDIFRMCQTK DLPVRDWVKL AVTRARATGD
     PAVFWLDETR AHDAQLITKV EAYLAEHDTE GLDIRVMSPV EATKFSLERI RRGENTISVT
     GNVLRDYLTD LFPILELGTS AKMLSIVPLM AGGGLFETGA GGSAPKHVQQ LVKENYLRWD
     SLGEFFALVP SLEQYAKTTG NTRAQVLADT LDRATATFLD EDKSPTRRIG GIDNRGSHFY
     LAMYWAQELA RQTEDAQLAE AFADLARTLT EQESTIVDEL NAVQGEPADI GGYYKPDPAK
     AAAVMRPSET FNRAIASLS
//
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