ID F8JYI6_STREN Unreviewed; 1068 AA.
AC F8JYI6; G8WXQ4;
DT 21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT 21-SEP-2011, sequence version 1.
DT 03-APR-2013, entry version 12.
DE SubName: Full=Bifunctional P-450/NADPH-P450 reductase;
DE EC=1.14.14.1;
DE EC=1.6.2.4;
DE SubName: Full=Bifunctional P-450:NADPH-P450 reductase 1;
GN Name=CYP102A; OrderedLocusNames=SCAT_4838, SCATT_48330;
OS Streptomyces cattleya (strain ATCC 35852 / DSM 46488 / JCM 4925 / NBRC
OS 14057 / NRRL 8057).
OC Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC Streptomycineae; Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1003195;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35852 / DSM 46488 / JCM 4925 / NBRC 14057 / NRRL 8057, and
RC NRRL 8057;
RX PubMed=21868806; DOI=10.1128/JB.05583-11;
RA Barbe V., Bouzon M., Mangenot S., Badet B., Poulain J., Segurens B.,
RA Vallenet D., Marliere P., Weissenbach J.;
RT "Complete genome sequence of Streptomyces cattleya NRRL 8057, a
RT producer of antibiotics and fluorometabolites.";
RL J. Bacteriol. 193:5055-5056(2011).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=NRRL 8057;
RA Genoscope - CEA;
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35852 / DSM 46488 / JCM 4925 / NBRC 14057 / NRRL 8057;
RA Ou H.-Y., Li P., Zhao C., O'Hagan D., Deng Z.;
RT "Complete genome sequence of Streptomyces cattleya strain DSM 46488.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=DSM 46488;
RA Ou H.-Y., Li P., Zhao C., O'Hagan D., Deng Z.;
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR: Heme group (By similarity).
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DR EMBL; CP003219; AEW97204.1; -; Genomic_DNA.
DR EMBL; FQ859185; CCB77526.1; -; Genomic_DNA.
DR RefSeq; YP_004914329.1; NC_016111.1.
DR RefSeq; YP_006056726.1; NC_017586.1.
DR EnsemblBacteria; AEW97204; AEW97204; SCATT_48330.
DR EnsemblBacteria; CCB77526; CCB77526; SCAT_4838.
DR GeneID; 11358979; -.
DR GeneID; 12651603; -.
DR KEGG; sct:SCAT_4838; -.
DR KEGG; scy:SCATT_48330; -.
DR KO; K14338; -.
DR BioCyc; SCAT1003195:GJCM-4876-MONOMER; -.
DR GO; GO:0070330; F:aromatase activity; IEA:EC.
DR GO; GO:0009055; F:electron carrier activity; IEA:InterPro.
DR GO; GO:0010181; F:FMN binding; IEA:InterPro.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0003958; F:NADPH-hemoprotein reductase activity; IEA:EC.
DR Gene3D; 1.10.630.10; -; 1.
DR Gene3D; 1.20.990.10; -; 1.
DR InterPro; IPR023206; Bifunctional_P450_P450_red.
DR InterPro; IPR001128; Cyt_P450.
DR InterPro; IPR017972; Cyt_P450_CS.
DR InterPro; IPR002401; Cyt_P450_E_grp-I.
DR InterPro; IPR003097; FAD-binding_1.
DR InterPro; IPR017927; Fd_Rdtase_FAD-bd.
DR InterPro; IPR008254; Flavodoxin/NO_synth.
DR InterPro; IPR023173; NADPH_Cyt_P450_Rdtase_dom3.
DR InterPro; IPR001433; OxRdtase_FAD/NAD-bd.
DR InterPro; IPR017938; Riboflavin_synthase-like_b-brl.
DR Pfam; PF00667; FAD_binding_1; 1.
DR Pfam; PF00258; Flavodoxin_1; 1.
DR Pfam; PF00175; NAD_binding_1; 1.
DR Pfam; PF00067; p450; 1.
DR PIRSF; PIRSF000209; Bifunctional_P450_P450R; 1.
DR PRINTS; PR00463; EP450I.
DR PRINTS; PR00385; P450.
DR SUPFAM; SSF48264; Cytochrome_P450; 1.
DR SUPFAM; SSF63380; Riboflavin_synthase_like_b-brl; 1.
DR PROSITE; PS00086; CYTOCHROME_P450; 1.
DR PROSITE; PS51384; FAD_FR; 1.
DR PROSITE; PS50902; FLAVODOXIN_LIKE; 1.
PE 3: Inferred from homology;
KW Complete proteome; Heme; Iron; Metal-binding; Oxidoreductase.
FT METAL 423 423 Iron (heme axial ligand) (By similarity).
SQ SEQUENCE 1068 AA; 113412 MW; 0F526D1C7D663C12 CRC64;
MSPTPHSASG TTGAAAATPG AASPAPPVPV ADISDTGFGT TPIQQAMALA REHGPVFRRR
FGTFESLLVG SVDAVTELCD DERFVKAVGP VLTNVRQIAG DGLFTAYNDE PNWAKAHDIL
LPAFALSSMH TYHPTMLRVA KRLIAAWDTA LADGAPVDVA DDMTRMTLDT IGLAGFGYDF
GSFRRGEPHP FVAAMVRGLL HSQALLSRKA DDGVDHSAAD EAFRADNAYL AQVVDEVIEA
RRASGETGTD DLLGLMLGAP HPSDGTPLDA ANIRNQVITF LIAGHETTSG ALSFALYYLA
KNPAVLRRAQ AEVDALWGDD PDPEPDYTDV GRLTYVRQVL NEALRLWPTA AAFGRQAVTD
TVLDGRVPMR AGDTALVLTP VLHRDPVWGD NVEAFDPERF SPEREAARPV HAFKPFGTGE
RACIGRQFAL HEAVMLLGML IHRYRFLDHA DYRLRVRETL TLKPDGFTLK LARRTSADRV
RTVASRAAEG TAGQDAGLPT TARPGTTLTV LHGSNLGACR EFAAGLADLG ERCGFETTVA
PLDAYRAGDL PRTSPVVVVA ASYNGRPTDD AAGFVSWLEQ AGPGAADGVR YAVLGVGDRN
WAATYQKVPT LIDERLAECG ATRLLERAAA DAAGDLAGTV RGFGEALRRA LLAEYGDPDS
VGAVAGAEDG YEVTEVTGGP LDALAARHEV VAMTVTETGD LADLTHPLGR SKRFVRLALP
DGATYRTGDH LAVLPANDPA LVERAARLLG ADPDTVLGVR ARRPGRGTLP VDRPVTVREL
LTYHLELSDP ATAAQIAVLA DRNPCPPEQA ELKKLAPGRA SVLDLVERYP ALTGRLDWPT
VLGTLLPQIR IRHYSVSSSP AVSPGHVDLM VSLLEADGRR GTGSGHLHRV RPGDVVYARV
APCREAFRIA AGDEVPVVMV AAGTGLAPFR GAVADRVALR SAGRELAPAL LYFGCDHPEV
DFLHAAELRG AEAAGAVSLR PAFSAAPDGD VRFVQHRIAA EADEVWSLLK GGARVYVCGD
GSRMAPGVRE AFTALYASRT GATAEQAAGW LADLVARGRY VEDVYAAG
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