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Database: UniProt/TrEMBL
Entry: F8JYI6_STREN
LinkDB: F8JYI6_STREN
Original site: F8JYI6_STREN 
ID   F8JYI6_STREN            Unreviewed;      1068 AA.
AC   F8JYI6; G8WXQ4;
DT   21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT   21-SEP-2011, sequence version 1.
DT   26-NOV-2014, entry version 20.
DE   SubName: Full=Bifunctional P-450/NADPH-P450 reductase {ECO:0000313|EMBL:CCB77526.1};
DE            EC=1.14.14.1 {ECO:0000313|EMBL:CCB77526.1};
DE            EC=1.6.2.4 {ECO:0000313|EMBL:CCB77526.1};
DE   SubName: Full=Bifunctional P-450:NADPH-P450 reductase 1 {ECO:0000313|EMBL:AEW97204.1};
GN   Name=CYP102A {ECO:0000313|EMBL:CCB77526.1};
GN   OrderedLocusNames=SCAT_4838 {ECO:0000313|EMBL:CCB77526.1}, SCATT_48330
GN   {ECO:0000313|EMBL:AEW97204.1};
OS   Streptomyces cattleya (strain ATCC 35852 / DSM 46488 / JCM 4925 / NBRC
OS   14057 / NRRL 8057).
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Streptomycineae; Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1003195 {ECO:0000313|EMBL:CCB77526.1, ECO:0000313|Proteomes:UP000006623};
RN   [1] {ECO:0000313|EMBL:CCB77526.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NRRL 8057 {ECO:0000313|EMBL:CCB77526.1};
RX   PubMed=21868806; DOI=10.1128/JB.05583-11;
RA   Barbe V., Bouzon M., Mangenot S., Badet B., Poulain J., Segurens B.,
RA   Vallenet D., Marliere P., Weissenbach J.;
RT   "Complete genome sequence of Streptomyces cattleya NRRL 8057, a
RT   producer of antibiotics and fluorometabolites.";
RL   J. Bacteriol. 193:5055-5056(2011).
RN   [2] {ECO:0000313|EMBL:CCB77526.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=NRRL 8057 {ECO:0000313|EMBL:CCB77526.1};
RA   Genoscope - CEA;
RL   Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Proteomes:UP000006623, ECO:0000313|Proteomes:UP000007842}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35852 / DSM 46488 / JCM 4925 / NBRC 14057 / NRRL 8057
RC   {ECO:0000313|Proteomes:UP000006623,
RC   ECO:0000313|Proteomes:UP000007842};
RA   Ou H.-Y., Li P., Zhao C., O'Hagan D., Deng Z.;
RT   "Complete genome sequence of Streptomyces cattleya strain DSM 46488.";
RL   Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|EMBL:AEW97204.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=DSM 46488 {ECO:0000313|EMBL:AEW97204.1};
RA   Ou H.-Y., Li P., Zhao C., O'Hagan D., Deng Z.;
RL   Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Note=Heme group. {ECO:0000256|PIRSR:PIRSR000209-1};
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DR   EMBL; CP003219; AEW97204.1; -; Genomic_DNA.
DR   EMBL; FQ859185; CCB77526.1; -; Genomic_DNA.
DR   RefSeq; WP_014145542.1; NC_017586.1.
DR   RefSeq; YP_004914329.1; NC_016111.1.
DR   RefSeq; YP_006056726.1; NC_017586.1.
DR   EnsemblBacteria; AEW97204; AEW97204; SCATT_48330.
DR   EnsemblBacteria; CCB77526; CCB77526; SCAT_4838.
DR   GeneID; 11358979; -.
DR   GeneID; 12651603; -.
DR   KEGG; sct:SCAT_4838; -.
DR   KEGG; scy:SCATT_48330; -.
DR   KO; K14338; -.
DR   BioCyc; SCAT1003195:GJCM-4876-MONOMER; -.
DR   GO; GO:0070330; F:aromatase activity; IEA:UniProtKB-EC.
DR   GO; GO:0010181; F:FMN binding; IEA:InterPro.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0003958; F:NADPH-hemoprotein reductase activity; IEA:UniProtKB-EC.
DR   Gene3D; 1.10.630.10; -; 1.
DR   Gene3D; 1.20.990.10; -; 1.
DR   Gene3D; 3.40.50.360; -; 1.
DR   InterPro; IPR023206; Bifunctional_P450_P450_red.
DR   InterPro; IPR001128; Cyt_P450.
DR   InterPro; IPR017972; Cyt_P450_CS.
DR   InterPro; IPR002401; Cyt_P450_E_grp-I.
DR   InterPro; IPR003097; FAD-binding_1.
DR   InterPro; IPR017927; Fd_Rdtase_FAD-bd.
DR   InterPro; IPR008254; Flavodoxin/NO_synth.
DR   InterPro; IPR029039; Flavoprotein-like.
DR   InterPro; IPR023173; NADPH_Cyt_P450_Rdtase_dom3.
DR   InterPro; IPR001433; OxRdtase_FAD/NAD-bd.
DR   InterPro; IPR017938; Riboflavin_synthase-like_b-brl.
DR   Pfam; PF00667; FAD_binding_1; 1.
DR   Pfam; PF00258; Flavodoxin_1; 1.
DR   Pfam; PF00175; NAD_binding_1; 1.
DR   Pfam; PF00067; p450; 1.
DR   PIRSF; PIRSF000209; Bifunctional_P450_P450R; 1.
DR   PRINTS; PR00463; EP450I.
DR   PRINTS; PR00385; P450.
DR   SUPFAM; SSF48264; SSF48264; 1.
DR   SUPFAM; SSF52218; SSF52218; 1.
DR   SUPFAM; SSF63380; SSF63380; 1.
DR   PROSITE; PS00086; CYTOCHROME_P450; 1.
DR   PROSITE; PS51384; FAD_FR; 1.
DR   PROSITE; PS50902; FLAVODOXIN_LIKE; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000007842};
KW   Heme {ECO:0000256|PIRSR:PIRSR000209-1};
KW   Iron {ECO:0000256|PIRSR:PIRSR000209-1};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR000209-1};
KW   Oxidoreductase {ECO:0000313|EMBL:CCB77526.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007842}.
FT   METAL       423    423       Iron (heme axial ligand).
FT                                {ECO:0000256|PIRSR:PIRSR000209-1}.
SQ   SEQUENCE   1068 AA;  113412 MW;  0F526D1C7D663C12 CRC64;
     MSPTPHSASG TTGAAAATPG AASPAPPVPV ADISDTGFGT TPIQQAMALA REHGPVFRRR
     FGTFESLLVG SVDAVTELCD DERFVKAVGP VLTNVRQIAG DGLFTAYNDE PNWAKAHDIL
     LPAFALSSMH TYHPTMLRVA KRLIAAWDTA LADGAPVDVA DDMTRMTLDT IGLAGFGYDF
     GSFRRGEPHP FVAAMVRGLL HSQALLSRKA DDGVDHSAAD EAFRADNAYL AQVVDEVIEA
     RRASGETGTD DLLGLMLGAP HPSDGTPLDA ANIRNQVITF LIAGHETTSG ALSFALYYLA
     KNPAVLRRAQ AEVDALWGDD PDPEPDYTDV GRLTYVRQVL NEALRLWPTA AAFGRQAVTD
     TVLDGRVPMR AGDTALVLTP VLHRDPVWGD NVEAFDPERF SPEREAARPV HAFKPFGTGE
     RACIGRQFAL HEAVMLLGML IHRYRFLDHA DYRLRVRETL TLKPDGFTLK LARRTSADRV
     RTVASRAAEG TAGQDAGLPT TARPGTTLTV LHGSNLGACR EFAAGLADLG ERCGFETTVA
     PLDAYRAGDL PRTSPVVVVA ASYNGRPTDD AAGFVSWLEQ AGPGAADGVR YAVLGVGDRN
     WAATYQKVPT LIDERLAECG ATRLLERAAA DAAGDLAGTV RGFGEALRRA LLAEYGDPDS
     VGAVAGAEDG YEVTEVTGGP LDALAARHEV VAMTVTETGD LADLTHPLGR SKRFVRLALP
     DGATYRTGDH LAVLPANDPA LVERAARLLG ADPDTVLGVR ARRPGRGTLP VDRPVTVREL
     LTYHLELSDP ATAAQIAVLA DRNPCPPEQA ELKKLAPGRA SVLDLVERYP ALTGRLDWPT
     VLGTLLPQIR IRHYSVSSSP AVSPGHVDLM VSLLEADGRR GTGSGHLHRV RPGDVVYARV
     APCREAFRIA AGDEVPVVMV AAGTGLAPFR GAVADRVALR SAGRELAPAL LYFGCDHPEV
     DFLHAAELRG AEAAGAVSLR PAFSAAPDGD VRFVQHRIAA EADEVWSLLK GGARVYVCGD
     GSRMAPGVRE AFTALYASRT GATAEQAAGW LADLVARGRY VEDVYAAG
//
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