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Database: UniProt/TrEMBL
Entry: F9V9A3_LACGT
LinkDB: F9V9A3_LACGT
Original site: F9V9A3_LACGT 
ID   F9V9A3_LACGT            Unreviewed;       738 AA.
AC   F9V9A3;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   16-APR-2014, entry version 19.
DE   RecName: Full=Phosphoribosylformylglycinamidine synthase 2;
DE            EC=6.3.5.3;
DE   AltName: Full=Phosphoribosylformylglycinamidine synthase II;
GN   Name=purL; OrderedLocusNames=LCGT_1181; ORFNames=I578_00808,
GN   OO3_00423;
OS   Lactococcus garvieae (strain ATCC 49156 / DSM 6783 / NCIMB 13208 /
OS   YT-3) (Enterococcus seriolicida).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Lactococcus.
OX   NCBI_TaxID=420889;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 49156, and ATCC 49156 / DSM 6783 / NCIMB 13208 / YT-3;
RX   PubMed=21829716; DOI=10.1371/journal.pone.0023184;
RA   Morita H., Toh H., Oshima K., Yoshizaki M., Kawanishi M., Nakaya K.,
RA   Suzuki T., Miyauchi E., Ishii Y., Tanabe S., Murakami M., Hattori M.;
RT   "Complete genome sequence and comparative analysis of the fish
RT   pathogen Lactococcus garvieae.";
RL   PLoS ONE 6:E23184-E23184(2011).
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=ATCC 49156;
RG   The Broad Institute Genomics Platform;
RG   The Broad Institute Genome Sequencing Center for Infectious Disease;
RA   Earl A., Russ C., Gilmore M., Surin D., Walker B., Young S., Zeng Q.,
RA   Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W.,
RA   Alvarado L., Arachchi H.M., Berlin A.M., Chapman S.B.,
RA   Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA   Howarth C., Imamovic A., Ireland A., Larimer J., McCowan C.,
RA   Murphy C., Pearson M., Poon T.W., Priest M., Roberts A., Saif S.,
RA   Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT   "The Genome Sequence of Lactococcus garvieae ATCC_49156 (Illumina only
RT   assembly).";
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=ATCC 49156;
RG   The Broad Institute Genomics Platform;
RG   The Broad Institute Genome Sequencing Center for Infectious Disease;
RA   Earl A., Russ C., Gilmore M., Surin D., Walker B., Young S., Zeng Q.,
RA   Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W.,
RA   Alvarado L., Arachchi H.M., Berlin A.M., Chapman S.B.,
RA   Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA   Howarth C., Imamovic A., Ireland A., Larimer J., McCowan C.,
RA   Murphy C., Pearson M., Poon T.W., Priest M., Roberts A., Saif S.,
RA   Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT   "The Genome Sequence of Lactococcus garvieae ATCC_49156
RT   (PacBio/Illumina hybrid assembly).";
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: ATP + N(2)-formyl-N(1)-(5-phospho-D-
CC       ribosyl)glycinamide + L-glutamine + H(2)O = ADP + phosphate + 2-
CC       (formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate.
CC   -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway;
CC       5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-
CC       phospho-D-ribosyl)glycinamide: step 1/2.
CC   -!- SUBUNIT: Heterodimer of two subunits, PurQ and PurL (By
CC       similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the FGAMS family.
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DR   EMBL; AP009332; BAK58694.1; -; Genomic_DNA.
DR   EMBL; AHYM01000002; EOT33233.1; -; Genomic_DNA.
DR   EMBL; ASWT01000006; EOT93272.1; -; Genomic_DNA.
DR   RefSeq; YP_004779358.1; NC_015930.1.
DR   EnsemblBacteria; BAK58694; BAK58694; LCGT_1181.
DR   GeneID; 11137279; -.
DR   KEGG; lgr:LCGT_1181; -.
DR   KO; K01952; -.
DR   BioCyc; LGAR420889:GH14-1201-MONOMER; -.
DR   UniPathway; UPA00074; UER00128.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0004642; F:phosphoribosylformylglycinamidine synthase activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006189; P:'de novo' IMP biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.30.1330.10; -; 2.
DR   HAMAP; MF_00420; PurL_2; 1.
DR   InterPro; IPR010918; AIR_synth_C_dom.
DR   InterPro; IPR000728; AIR_synth_N_dom.
DR   InterPro; IPR010074; PRibForGlyAmidine_synth_II.
DR   InterPro; IPR016188; PurM_N-like.
DR   Pfam; PF00586; AIRS; 2.
DR   Pfam; PF02769; AIRS_C; 2.
DR   SUPFAM; SSF55326; SSF55326; 2.
DR   SUPFAM; SSF56042; SSF56042; 2.
DR   TIGRFAMs; TIGR01736; FGAM_synth_II; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Cytoplasm; Ligase; Nucleotide-binding;
KW   Purine biosynthesis.
FT   NP_BIND     111    122       ATP (By similarity).
SQ   SEQUENCE   738 AA;  79586 MW;  8E087BE12723C4F6 CRC64;
     MSGEMSPEQI QASKIYREWG LTDEEYSKIK NEILGGRLPN FTETGMYAVM WSEHCCYKNS
     KPVLKKFPTE GPQVLIGPGE GAGVVDIGEG WAVVFKAESH NHPSYVEPYE GAATGSGGII
     RDIFSMGARP VALLDSLRFG QIDNAKTRHI VERVTAGIAG YGNCIGIPTV GGEVAFDESY
     AGNPLVNVMC IGLIEHKHIQ KGQAKGVGNT IMYVGAKTGR DGIHGASFAS QEFGSGSETQ
     RSAVQVGDPF MEKLLLEACL EVIHNHSDIL VGIQDMGAAG LVSSTSEMAS KAGSGLKLNL
     DLVPQRETNM TPYEMMLSES QERMVLCIKK GHEDEIVELF KKYELDAVNI GEVTDDGMYT
     LFHQGEKVAE IPVDSLAEDA PVYSREMKEP ARIAEFVKAE KFIPEIANAT EVLKDLLSQP
     TIASKRSIYE TYDGRVMTNT VVAPGSDAAV IRLRHSNKAL AMTTDCNARY LYLNPEIGGQ
     IAVAEAARNI IASGGKPLAI TDCLNFGNPE KPEQFYELSK ACDGVSESCR VLSTPVISGN
     VSLYNETNGQ AILPTPMIGM VGLIEDVTHI TTQDFKDAGD LIYIIGETAD DFSGSEIQKM
     MTGKISGTLN FDLQAEKENQ KHVLKAIQAG LVKSAHDLSE GGLAVALVES AFANNKGISV
     HFEGKVSQLF SESQGRFILS VHPKDEKNFE ALMAGKASKL GQVTDKSEIK ISAKDGEISL
     STAEAKAIYE GAIPCLMK
//
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