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Database: UniProt/TrEMBL
Entry: G0FKG9_AMYMS
LinkDB: G0FKG9_AMYMS
Original site: G0FKG9_AMYMS 
ID   G0FKG9_AMYMS            Unreviewed;      1235 AA.
AC   G0FKG9;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   05-JUL-2017, entry version 33.
DE   SubName: Full=Alpha-ketoglutarate decarboxylase {ECO:0000313|EMBL:AEK46638.1};
DE            EC=4.1.1.71 {ECO:0000313|EMBL:AEK46638.1};
GN   Name=kgd {ECO:0000313|EMBL:AEK46638.1};
GN   OrderedLocusNames=RAM_40855 {ECO:0000313|EMBL:AEK46638.1};
OS   Amycolatopsis mediterranei (strain S699) (Nocardia mediterranei).
OC   Bacteria; Actinobacteria; Pseudonocardiales; Pseudonocardiaceae;
OC   Amycolatopsis.
OX   NCBI_TaxID=713604 {ECO:0000313|EMBL:AEK46638.1, ECO:0000313|Proteomes:UP000006138};
RN   [1] {ECO:0000313|EMBL:AEK46638.1, ECO:0000313|Proteomes:UP000006138}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=S699 {ECO:0000313|EMBL:AEK46638.1,
RC   ECO:0000313|Proteomes:UP000006138};
RX   PubMed=21914879; DOI=10.1128/JB.05819-11;
RA   Verma M., Kaur J., Kumar M., Kumari K., Saxena A., Anand S., Nigam A.,
RA   Ravi V., Raghuvanshi S., Khurana P., Tyagi A.K., Khurana J.P., Lal R.;
RT   "Whole genome sequence of the rifamycin B-producing strain
RT   Amycolatopsis mediterranei S699.";
RL   J. Bacteriol. 193:5562-5563(2011).
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DR   EMBL; CP002896; AEK46638.1; -; Genomic_DNA.
DR   RefSeq; WP_014467712.1; NC_018266.1.
DR   EnsemblBacteria; AEK46638; AEK46638; RAM_40855.
DR   KEGG; amn:RAM_40855; -.
DR   PATRIC; fig|713604.4.peg.8171; -.
DR   KO; K01616; -.
DR   OMA; IDMVCYR; -.
DR   OrthoDB; POG091H03SK; -.
DR   Proteomes; UP000006138; Chromosome.
DR   GO; GO:0008683; F:2-oxoglutarate decarboxylase activity; IEA:UniProtKB-EC.
DR   GO; GO:0004591; F:oxoglutarate dehydrogenase (succinyl-transferring) activity; IEA:InterPro.
DR   GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR   GO; GO:0016746; F:transferase activity, transferring acyl groups; IEA:InterPro.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR   InterPro; IPR001078; 2-oxoacid_DH_actylTfrase.
DR   InterPro; IPR032106; 2-oxogl_dehyd_N.
DR   InterPro; IPR011603; 2oxoglutarate_DH_E1.
DR   InterPro; IPR001017; DH_E1.
DR   InterPro; IPR031717; KGD_C.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR005475; Transketolase-like_Pyr-bd.
DR   PANTHER; PTHR23152; PTHR23152; 1.
DR   Pfam; PF00198; 2-oxoacid_dh; 1.
DR   Pfam; PF16078; 2-oxogl_dehyd_N; 1.
DR   Pfam; PF00676; E1_dh; 1.
DR   Pfam; PF16870; OxoGdeHyase_C; 1.
DR   Pfam; PF02779; Transket_pyr; 1.
DR   PIRSF; PIRSF000157; Oxoglu_dh_E1; 1.
DR   SMART; SM00861; Transket_pyr; 1.
DR   SUPFAM; SSF52518; SSF52518; 2.
DR   TIGRFAMs; TIGR00239; 2oxo_dh_E1; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000006138};
KW   Lyase {ECO:0000313|EMBL:AEK46638.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006138}.
FT   DOMAIN      894   1087       Transket_pyr. {ECO:0000259|SMART:
FT                                SM00861}.
FT   COILED      804    831       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1235 AA;  136004 MW;  1B9692F6443D0C2C CRC64;
     MSSSSPASQF GPNEWLVEEM YDQFLADPSS VDAAWHDFFA DFKPTQSAQA KADTARQQQA
     GAKPAANGQA AQPSAKAVQN AESAAKQSST APAAKPAPAK AAPKQAPKPA AKAEPKAEAK
     KEEPESKQLR GAAAAIAKNM DASLSVPTAT SVRAVPAKLM ADNRIVINNH LKRTRGGKIS
     FTHLIGYAMV RALKAYPNMN RHYQLIDGKP FAITPEHVNF GLAIDMKGKD GSRTLVVASI
     KGCEDMSFLQ FWQAYEDIVK KARNNKLTAD DFSGTTISLT NPGGIGTNHS VPRLQAGQGA
     IIGVGAMQYP AAFEGTSEKT LVDLGISKIM TLTSTYDHRI IQGAESGEFL KRIHQLLLGE
     DGFYDDVFTS LRLPYEPIRW VADIPDGPVD KTARVIELID AFRMRGHLMA DTDPLNYRQR
     SHADLDVLSH GLTLWDLDRE FPVGGFAGQE RMKLRDILGV LRNSYCRTVG IEYTHILDPE
     ERRWIQERVE IPHEKPDPAV QKYVLSKLNA AEAFETFLQT KYVGQKRFSL EGGETAIPLL
     DTILDKAAEH ELDEVVIGMP HRGRLNVLAN IVGKPISQIF QEFEGNLDPG QAHGSGDVKY
     HLGAEGKYFR MFGDGETKVS LTANPSHLET VDPVLEGIVR AKQDILDKGG EGYTVLPVLM
     HGDAAFAGQG VVAETLNLSL LRGYRTGGTV HVIVNNQVGF TTAPEHSRSS QYATDVAKMI
     GSPIFHVNGD DPEAAHWVAK LAVEYRQAFH KDVVIDLICY RRRGHNEGDD PSMTQPAMYD
     IIDTKRSVRK TYTESLIGRG DISVEEAEAA LRDFSSQLEH VFNEVRELEK HPAKASPSVE
     EEQQVPAKVA TAITGKTLEH IGDAFVNVPD GFTPHPRVKP VMERRHKMSR EGDIDWAFGE
     LLAFGSLAME GRLVRLSGQD SRRGTFTQRH SVFIDRKTGQ EYSPLQNLAD GQGRVMIYDS
     ALSEYAAVGF EYGYSVANPE SLVMWEAQFG DFVNGAQTVI DEYISSGEAK WGQRSDVVLL
     LPHGHEGQGP DHTSGRIERF LSLCAEGSMT VAVPSTPANY FHLLRRHALD GIQRPLVVFT
     PKSMLRNKAA TSPTEDFTGE SRFMSVIDDV TPDPAKIRKV LLTSGKLYWE LVAERTKREA
     DDVAIVRIEQ YYPLPKKKLL AALERYTNAT QVAWVQEEPE NQGAWPFFGL NLPRKFPEVL
     SGLQVVSRRP MAAPSAGSSK VHEVEQKALI AKAFD
//
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