ID G0HFF6_CORVD Unreviewed; 424 AA.
AC G0HFF6;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 03-APR-2013, entry version 16.
DE RecName: Full=Aspartokinase;
DE EC=2.7.2.4;
GN Name=lysC; OrderedLocusNames=CVAR_2500;
OS Corynebacterium variabile (strain DSM 44702 / JCM 12073 / NCIMB 30131)
OS (Corynebacterium mooreparkense).
OC Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC Corynebacterineae; Corynebacteriaceae; Corynebacterium.
OX NCBI_TaxID=858619;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 44702 / JCM 12073 / NCIMB 30131;
RX PubMed=22053731; DOI=10.1186/1471-2164-12-545;
RA Schroeder J., Maus I., Trost E., Tauch A.;
RT "Complete genome sequence of Corynebacterium variabile DSM 44702
RT isolated from the surface of smear-ripened cheeses and insights into
RT cheese ripening and flavor generation.";
RL BMC Genomics 12:545-545(2011).
CC -!- CATALYTIC ACTIVITY: ATP + L-aspartate = ADP + 4-phospho-L-
CC aspartate.
CC -!- PATHWAY: Amino-acid biosynthesis; L-lysine biosynthesis via DAP
CC pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 1/4.
CC -!- PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via de
CC novo pathway; L-homoserine from L-aspartate: step 1/3.
CC -!- PATHWAY: Amino-acid biosynthesis; L-threonine biosynthesis; L-
CC threonine from L-aspartate: step 1/5.
CC -!- SIMILARITY: Belongs to the aspartokinase family.
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DR EMBL; CP002917; AEK37845.1; -; Genomic_DNA.
DR RefSeq; YP_004760918.1; NC_015859.1.
DR EnsemblBacteria; AEK37845; AEK37845; CVAR_2500.
DR GeneID; 11001296; -.
DR KEGG; cva:CVAR_2500; -.
DR KO; K00928; -.
DR BioCyc; CVAR858619:GHOU-2562-MONOMER; -.
DR UniPathway; UPA00034; UER00015.
DR UniPathway; UPA00050; UER00461.
DR UniPathway; UPA00051; UER00462.
DR GO; GO:0016597; F:amino acid binding; IEA:InterPro.
DR GO; GO:0004072; F:aspartate kinase activity; IEA:EC.
DR GO; GO:0009089; P:lysine biosynthetic process via diaminopimelate; IEA:UniProtKB-UniPathway.
DR GO; GO:0009088; P:threonine biosynthetic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.40.1160.10; -; 1.
DR InterPro; IPR002912; ACT_dom.
DR InterPro; IPR001048; Asp/Glu/Uridylate_kinase.
DR InterPro; IPR005260; Asp_kin_monofn.
DR InterPro; IPR001341; Asp_kinase_dom.
DR InterPro; IPR018042; Aspartate_kinase_CS.
DR Pfam; PF00696; AA_kinase; 1.
DR Pfam; PF01842; ACT; 1.
DR PIRSF; PIRSF000726; Asp_kin; 1.
DR SUPFAM; SSF53633; Aa_kinase; 1.
DR TIGRFAMs; TIGR00656; asp_kin_monofn; 1.
DR TIGRFAMs; TIGR00657; asp_kinases; 1.
DR PROSITE; PS00324; ASPARTOKINASE; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis; Complete proteome; Kinase; Transferase.
SQ SEQUENCE 424 AA; 45159 MW; BB9C511B50F02B14 CRC64;
MALIVQKYGG SSLESAERIR RVAQRIVETK KAGNDVVVVC SAMGDTTDEL LDLANQVNPV
PPGREMDMLL TAGERISNAL VAMAINSFGA EAQSFTGSQA GVITTERHGN ARIVDVTPGR
VREALDEGKI CLVAGFQGVN RETKDITTLG RGGSDTTAVA LAAALKADVC EIYSDVDGVY
TADPRIVSNA QKLDHISFEE MLEMAAVGAK ILMLRCVEYA RAFNVPIHVR SSFSNETGTI
VSGSVEDIPV EEAVLTGVAH DRSEAKVTVL GIPDKPGEAA RVFRTLADAE INIDMVLQNI
STVNDNLTDI TFTCPREDAP RAVELLNGLQ GPEADQKFGS IVFDDQIGKV SLVGAGMKSH
PGVTADFCEA LRDVGINIEL ISTSEIRISV LIRDTDLDKA VAALHERFQL GGETEAVVHA
GTGR
//
