ID G0HJT4_THES4 Unreviewed; 174 AA.
AC G0HJT4;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 03-APR-2013, entry version 15.
DE RecName: Full=Nucleoside diphosphate kinase;
DE Short=NDK;
DE Short=NDP kinase;
DE EC=2.7.4.6;
DE AltName: Full=Nucleoside-2-P kinase;
GN Name=ndk; OrderedLocusNames=GQS_00215;
OS Thermococcus sp. (strain CGMCC 1.5172 / 4557).
OC Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC Thermococcus.
OX NCBI_TaxID=1042877;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CGMCC 1.5172 / 4557;
RX PubMed=21914870; DOI=10.1128/JB.05851-11;
RA Wang X., Gao Z., Xu X., Ruan L.;
RT "Complete genome sequence of Thermococcus sp. strain 4557, a
RT hyperthermophilic archaeon isolated from a deep-sea hydrothermal vent
RT area.";
RL J. Bacteriol. 193:5544-5545(2011).
CC -!- FUNCTION: Major role in the synthesis of nucleoside triphosphates
CC other than ATP. The ATP gamma phosphate is transferred to the NDP
CC beta phosphate via a ping-pong mechanism, using a phosphorylated
CC active-site intermediate (By similarity).
CC -!- CATALYTIC ACTIVITY: ATP + nucleoside diphosphate = ADP +
CC nucleoside triphosphate.
CC -!- COFACTOR: Magnesium (By similarity).
CC -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC -!- SIMILARITY: Belongs to the NDK family.
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DR EMBL; CP002920; AEK71946.1; -; Genomic_DNA.
DR RefSeq; YP_004761623.1; NC_015865.1.
DR EnsemblBacteria; AEK71946; AEK71946; GQS_00215.
DR GeneID; 11014691; -.
DR KEGG; the:GQS_00215; -.
DR KO; K00940; -.
DR OMA; IARFERK; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:HAMAP.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004550; F:nucleoside diphosphate kinase activity; IEA:HAMAP.
DR GO; GO:0006241; P:CTP biosynthetic process; IEA:HAMAP.
DR GO; GO:0006183; P:GTP biosynthetic process; IEA:HAMAP.
DR GO; GO:0006228; P:UTP biosynthetic process; IEA:HAMAP.
DR Gene3D; 3.30.70.141; -; 1.
DR HAMAP; MF_00451; NDP_kinase; 1; -.
DR InterPro; IPR001564; Nucleoside_diP_kinase.
DR InterPro; IPR023005; Nucleoside_diP_kinase_AS.
DR PANTHER; PTHR11349; PTHR11349; 1.
DR Pfam; PF00334; NDK; 1.
DR PRINTS; PR01243; NUCDPKINASE.
DR SMART; SM00562; NDK; 1.
DR SUPFAM; SSF54919; NDK; 1.
DR PROSITE; PS00469; NDP_KINASES; 1.
PE 3: Inferred from homology;
KW ATP-binding; Complete proteome; Cytoplasm; Endonuclease; Kinase;
KW Magnesium; Metal-binding; Nucleotide metabolism; Nucleotide-binding;
KW Phosphoprotein; Transferase.
FT ACT_SITE 123 123 Pros-phosphohistidine intermediate (By
FT similarity).
FT BINDING 14 14 ATP (By similarity).
FT BINDING 62 62 ATP (By similarity).
FT BINDING 90 90 ATP (By similarity).
FT BINDING 96 96 ATP (By similarity).
FT BINDING 107 107 ATP (By similarity).
SQ SEQUENCE 174 AA; 20151 MW; A13564C4649237CC CRC64;
MVEKKIERTL VILKPDAVVR GLMGEIISRF EKRGLKIVGM KMIWIDREMA EKHYEEHKGK
PFFEPLIDYI TKAPSVVMVV EGRYAISVVR KMSGATDPKD AEPGSIRGDY GLDIGDSIYN
IIHASDSPES AEREINLYFK PDELYRYCKA ADWFYHTHAR AKREYLDTMD CLER
//
