ID G0TKD8_MYCCP Unreviewed; 358 AA.
AC G0TKD8;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 24-JAN-2024, entry version 52.
DE RecName: Full=DNA ligase (ATP) {ECO:0000256|ARBA:ARBA00012727};
DE EC=6.5.1.1 {ECO:0000256|ARBA:ARBA00012727};
GN Name=ligC {ECO:0000313|EMBL:CCC46084.1};
GN OrderedLocusNames=MCAN_37531 {ECO:0000313|EMBL:CCC46084.1};
OS Mycobacterium canettii (strain CIPT 140010059).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=1048245 {ECO:0000313|EMBL:CCC46084.1, ECO:0000313|Proteomes:UP000008896};
RN [1] {ECO:0000313|EMBL:CCC46084.1, ECO:0000313|Proteomes:UP000008896}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CIPT 140010059 {ECO:0000313|EMBL:CCC46084.1,
RC ECO:0000313|Proteomes:UP000008896};
RX PubMed=22389744; DOI=10.1371/journal.pntd.0001552;
RA Bentley S.D., Comas I., Bryant J.M., Walker D., Smith N.H., Harris S.R.,
RA Thurston S., Gagneux S., Wood J., Antonio M., Quail M.A., Gehre F.,
RA Adegbola R.A., Parkhill J., de Jong B.C.;
RT "The Genome of Mycobacterium Africanum West African 2 Reveals a Lineage-
RT Specific Locus and Genome Erosion Common to the M. tuberculosis Complex.";
RL PLoS Negl. Trop. Dis. 6:e1552-e1552(2012).
RN [2] {ECO:0000313|EMBL:CCC46084.1, ECO:0000313|Proteomes:UP000008896}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CIPT 140010059 {ECO:0000313|EMBL:CCC46084.1,
RC ECO:0000313|Proteomes:UP000008896};
RX PubMed=23291586; DOI=10.1038/ng.2517;
RA Supply P., Marceau M., Mangenot S., Roche D., Rouanet C., Khanna V.,
RA Majlessi L., Criscuolo A., Tap J., Pawlik A., Fiette L., Orgeur M.,
RA Fabre M., Parmentier C., Frigui W., Simeone R., Boritsch E.C., Debrie A.S.,
RA Willery E., Walker D., Quail M.A., Ma L., Bouchier C., Salvignol G.,
RA Sayes F., Cascioferro A., Seemann T., Barbe V., Locht C., Gutierrez M.C.,
RA Leclerc C., Bentley S.D., Stinear T.P., Brisse S., Medigue C., Parkhill J.,
RA Cruveiller S., Brosch R.;
RT "Genomic analysis of smooth tubercle bacilli provides insights into
RT ancestry and pathoadaptation of Mycobacterium tuberculosis.";
RL Nat. Genet. 45:172-179(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-
CC (deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP +
CC diphosphate.; EC=6.5.1.1; Evidence={ECO:0000256|ARBA:ARBA00034003};
CC -!- SIMILARITY: Belongs to the ATP-dependent DNA ligase family.
CC {ECO:0000256|ARBA:ARBA00007572}.
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DR EMBL; HE572590; CCC46084.1; -; Genomic_DNA.
DR RefSeq; WP_003420435.1; NC_015848.1.
DR AlphaFoldDB; G0TKD8; -.
DR SMR; G0TKD8; -.
DR GeneID; 45427731; -.
DR KEGG; mce:MCAN_37531; -.
DR HOGENOM; CLU_008325_4_1_11; -.
DR OMA; AGFRWHK; -.
DR Proteomes; UP000008896; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:UniProtKB-EC.
DR GO; GO:0006310; P:DNA recombination; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR CDD; cd07905; Adenylation_DNA_ligase_LigC; 1.
DR CDD; cd07970; OBF_DNA_ligase_LigC; 1.
DR Gene3D; 3.30.470.30; DNA ligase/mRNA capping enzyme; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR InterPro; IPR044119; Adenylation_LigC-like.
DR InterPro; IPR012309; DNA_ligase_ATP-dep_C.
DR InterPro; IPR012310; DNA_ligase_ATP-dep_cent.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR044117; OBF_LigC-like.
DR PANTHER; PTHR45674:SF4; DNA LIGASE 1; 1.
DR PANTHER; PTHR45674; DNA LIGASE 1/3 FAMILY MEMBER; 1.
DR Pfam; PF04679; DNA_ligase_A_C; 1.
DR Pfam; PF01068; DNA_ligase_A_M; 1.
DR SUPFAM; SSF56091; DNA ligase/mRNA capping enzyme, catalytic domain; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR PROSITE; PS50160; DNA_LIGASE_A3; 1.
PE 3: Inferred from homology;
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:CCC46084.1}.
FT DOMAIN 105..252
FT /note="ATP-dependent DNA ligase family profile"
FT /evidence="ECO:0000259|PROSITE:PS50160"
SQ SEQUENCE 358 AA; 40141 MW; 22DA33D1A56196BD CRC64;
MQLPVMPPVS PMLAKSVTAI PPDASYEPKW DGFRSICFRD GDQVELGSRN ERPMTRYFPE
LVAAIRAELP HRCVIDGEII IATDHGLDFE ALQQRIHPAE SRVRMLADRT PASFIAFDLL
ALGDDDYTGR PFSERRAALV DAVTGSGADA DLSIHVTPAT TDMATAQRWF SEFEGAGLDG
VIAKPPHITY QPDKRVMFKI KHLRTADCVV AGYRVHKSGS DAIGSLLLGL YQEDGQLASV
GVIGAFPMAE RRRLLTELQP LVTSFDDHPW NWAAHVAGQR TPRKNEFSRW NVGKDLSFVP
LRPERVVEVR YDHMEGARFR HTAQFNRWRP DRDPRSCSYA QLERPLTVSL SDIVPGLR
//