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Database: UniProt/TrEMBL
Entry: G0TKD8_MYCCP
LinkDB: G0TKD8_MYCCP
Original site: G0TKD8_MYCCP 
ID   G0TKD8_MYCCP            Unreviewed;       358 AA.
AC   G0TKD8;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   24-JAN-2024, entry version 52.
DE   RecName: Full=DNA ligase (ATP) {ECO:0000256|ARBA:ARBA00012727};
DE            EC=6.5.1.1 {ECO:0000256|ARBA:ARBA00012727};
GN   Name=ligC {ECO:0000313|EMBL:CCC46084.1};
GN   OrderedLocusNames=MCAN_37531 {ECO:0000313|EMBL:CCC46084.1};
OS   Mycobacterium canettii (strain CIPT 140010059).
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=1048245 {ECO:0000313|EMBL:CCC46084.1, ECO:0000313|Proteomes:UP000008896};
RN   [1] {ECO:0000313|EMBL:CCC46084.1, ECO:0000313|Proteomes:UP000008896}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CIPT 140010059 {ECO:0000313|EMBL:CCC46084.1,
RC   ECO:0000313|Proteomes:UP000008896};
RX   PubMed=22389744; DOI=10.1371/journal.pntd.0001552;
RA   Bentley S.D., Comas I., Bryant J.M., Walker D., Smith N.H., Harris S.R.,
RA   Thurston S., Gagneux S., Wood J., Antonio M., Quail M.A., Gehre F.,
RA   Adegbola R.A., Parkhill J., de Jong B.C.;
RT   "The Genome of Mycobacterium Africanum West African 2 Reveals a Lineage-
RT   Specific Locus and Genome Erosion Common to the M. tuberculosis Complex.";
RL   PLoS Negl. Trop. Dis. 6:e1552-e1552(2012).
RN   [2] {ECO:0000313|EMBL:CCC46084.1, ECO:0000313|Proteomes:UP000008896}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CIPT 140010059 {ECO:0000313|EMBL:CCC46084.1,
RC   ECO:0000313|Proteomes:UP000008896};
RX   PubMed=23291586; DOI=10.1038/ng.2517;
RA   Supply P., Marceau M., Mangenot S., Roche D., Rouanet C., Khanna V.,
RA   Majlessi L., Criscuolo A., Tap J., Pawlik A., Fiette L., Orgeur M.,
RA   Fabre M., Parmentier C., Frigui W., Simeone R., Boritsch E.C., Debrie A.S.,
RA   Willery E., Walker D., Quail M.A., Ma L., Bouchier C., Salvignol G.,
RA   Sayes F., Cascioferro A., Seemann T., Barbe V., Locht C., Gutierrez M.C.,
RA   Leclerc C., Bentley S.D., Stinear T.P., Brisse S., Medigue C., Parkhill J.,
RA   Cruveiller S., Brosch R.;
RT   "Genomic analysis of smooth tubercle bacilli provides insights into
RT   ancestry and pathoadaptation of Mycobacterium tuberculosis.";
RL   Nat. Genet. 45:172-179(2013).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-
CC         (deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP +
CC         diphosphate.; EC=6.5.1.1; Evidence={ECO:0000256|ARBA:ARBA00034003};
CC   -!- SIMILARITY: Belongs to the ATP-dependent DNA ligase family.
CC       {ECO:0000256|ARBA:ARBA00007572}.
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DR   EMBL; HE572590; CCC46084.1; -; Genomic_DNA.
DR   RefSeq; WP_003420435.1; NC_015848.1.
DR   AlphaFoldDB; G0TKD8; -.
DR   SMR; G0TKD8; -.
DR   GeneID; 45427731; -.
DR   KEGG; mce:MCAN_37531; -.
DR   HOGENOM; CLU_008325_4_1_11; -.
DR   OMA; AGFRWHK; -.
DR   Proteomes; UP000008896; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:UniProtKB-EC.
DR   GO; GO:0006310; P:DNA recombination; IEA:InterPro.
DR   GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR   CDD; cd07905; Adenylation_DNA_ligase_LigC; 1.
DR   CDD; cd07970; OBF_DNA_ligase_LigC; 1.
DR   Gene3D; 3.30.470.30; DNA ligase/mRNA capping enzyme; 1.
DR   Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR   InterPro; IPR044119; Adenylation_LigC-like.
DR   InterPro; IPR012309; DNA_ligase_ATP-dep_C.
DR   InterPro; IPR012310; DNA_ligase_ATP-dep_cent.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR044117; OBF_LigC-like.
DR   PANTHER; PTHR45674:SF4; DNA LIGASE 1; 1.
DR   PANTHER; PTHR45674; DNA LIGASE 1/3 FAMILY MEMBER; 1.
DR   Pfam; PF04679; DNA_ligase_A_C; 1.
DR   Pfam; PF01068; DNA_ligase_A_M; 1.
DR   SUPFAM; SSF56091; DNA ligase/mRNA capping enzyme, catalytic domain; 1.
DR   SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR   PROSITE; PS50160; DNA_LIGASE_A3; 1.
PE   3: Inferred from homology;
KW   Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:CCC46084.1}.
FT   DOMAIN          105..252
FT                   /note="ATP-dependent DNA ligase family profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50160"
SQ   SEQUENCE   358 AA;  40141 MW;  22DA33D1A56196BD CRC64;
     MQLPVMPPVS PMLAKSVTAI PPDASYEPKW DGFRSICFRD GDQVELGSRN ERPMTRYFPE
     LVAAIRAELP HRCVIDGEII IATDHGLDFE ALQQRIHPAE SRVRMLADRT PASFIAFDLL
     ALGDDDYTGR PFSERRAALV DAVTGSGADA DLSIHVTPAT TDMATAQRWF SEFEGAGLDG
     VIAKPPHITY QPDKRVMFKI KHLRTADCVV AGYRVHKSGS DAIGSLLLGL YQEDGQLASV
     GVIGAFPMAE RRRLLTELQP LVTSFDDHPW NWAAHVAGQR TPRKNEFSRW NVGKDLSFVP
     LRPERVVEVR YDHMEGARFR HTAQFNRWRP DRDPRSCSYA QLERPLTVSL SDIVPGLR
//
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