ID G1QYD9_NOMLE Unreviewed; 710 AA.
AC G1QYD9;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 24-JAN-2024, entry version 66.
DE SubName: Full=Transglutaminase 7 {ECO:0000313|Ensembl:ENSNLEP00000005960.1};
GN Name=TGM7 {ECO:0000313|Ensembl:ENSNLEP00000005960.1};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000005960.1, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000005960.1, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000005960.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC Evidence={ECO:0000256|PIRSR:PIRSR000459-2};
CC Note=Binds 1 Ca(2+) ion per subunit. {ECO:0000256|PIRSR:PIRSR000459-2};
CC -!- SIMILARITY: Belongs to the transglutaminase superfamily.
CC Transglutaminase family. {ECO:0000256|ARBA:ARBA00005968}.
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DR EMBL; ADFV01034297; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01034298; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01034299; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01034300; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003266846.1; XM_003266798.1.
DR AlphaFoldDB; G1QYD9; -.
DR Ensembl; ENSNLET00000006269.2; ENSNLEP00000005960.1; ENSNLEG00000004914.2.
DR GeneID; 100605556; -.
DR KEGG; nle:100605556; -.
DR CTD; 116179; -.
DR eggNOG; ENOG502QTRA; Eukaryota.
DR GeneTree; ENSGT01050000244866; -.
DR HOGENOM; CLU_013435_1_0_1; -.
DR OrthoDB; 5344745at2759; -.
DR TreeFam; TF324278; -.
DR Proteomes; UP000001073; Chromosome 6.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003810; F:protein-glutamine gamma-glutamyltransferase activity; IEA:InterPro.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR Gene3D; 3.90.260.10; Transglutaminase-like; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR002931; Transglutaminase-like.
DR InterPro; IPR036985; Transglutaminase-like_sf.
DR InterPro; IPR023608; Transglutaminase_animal.
DR InterPro; IPR013808; Transglutaminase_AS.
DR InterPro; IPR008958; Transglutaminase_C.
DR InterPro; IPR036238; Transglutaminase_C_sf.
DR InterPro; IPR001102; Transglutaminase_N.
DR PANTHER; PTHR11590; PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE; 1.
DR PANTHER; PTHR11590:SF41; PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE Z; 1.
DR Pfam; PF00927; Transglut_C; 1.
DR Pfam; PF01841; Transglut_core; 1.
DR Pfam; PF00868; Transglut_N; 1.
DR PIRSF; PIRSF000459; TGM_EBP42; 1.
DR SMART; SM00460; TGc; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF49309; Transglutaminase, two C-terminal domains; 2.
DR PROSITE; PS00547; TRANSGLUTAMINASES; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|PIRSR:PIRSR000459-2};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR000459-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073}.
FT DOMAIN 271..364
FT /note="Transglutaminase-like"
FT /evidence="ECO:0000259|SMART:SM00460"
FT ACT_SITE 279
FT /evidence="ECO:0000256|PIRSR:PIRSR000459-1"
FT ACT_SITE 338
FT /evidence="ECO:0000256|PIRSR:PIRSR000459-1"
FT ACT_SITE 361
FT /evidence="ECO:0000256|PIRSR:PIRSR000459-1"
FT BINDING 401
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR000459-2"
FT BINDING 403
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR000459-2"
FT BINDING 450
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR000459-2"
FT BINDING 455
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR000459-2"
SQ SEQUENCE 710 AA; 79674 MW; DD54403845303E44 CRC64;
MDQVATLQLE SVDLQSSRNN KEHHTQEMGV KRLAVRRGQP FYIGLSFSRP FQSQSDHITF
VAETGPKPSE LLGTRATFFL TRVRPGNVWG ASDFTIDSNS LQVSLVTPAN AVIGHYTLKI
EISQGQGHSV TYPLGTFIIL FNPWSPEDDV YLPSEILLQE YIMRDYGFVY KGHEKFITSW
PWNYGQFEED IIDICFEILN KSLYYLKNPA KDCSQRNDVV YVCRVVSAMI NSNDDNGVLQ
GNWGEDYSNG VSPLEWNGSV AILRQWSASG GQPVKYGQCW VFASVMCTVM RCLGVPTRVV
SNFRSAHNVD RNLTIDTYYD RNAEMLSTQK RDKIWNFHVW NECWMIRKDL PPGYNGWQVL
DPTPQQTSSG LFCCGPASVK AIREGDVHLA YDTPFVYAEV NADEVIWLLG DGQAQEILAH
NTSSIGKEIS TKMVGSDQRQ SITSSYKYPE GSPEERAVFM KASRKMLGPQ RASLPFLYLL
ESGGLRDQPA QLQLHLARIP EWGQDLQLLL RIRRVPDSTH PQGPIGLVVR FCAQALLHGG
GTQKPLWRHT LRLNLDFGKE TQWPLLLPYS NYRNKLTDEK LIRVCGIAEV EETGRSMLVL
KEISLEPPHL SIEVSERAEV GKALRVHITL TNTLMVALSS CTMVLEGSGL VNGQIVKDLG
TLVAGHTLQI QLDLYPTKAG PRQLQVLISS NEVKEIKGYK DVFVTVAGAP
//