ID G1RZJ6_NOMLE Unreviewed; 808 AA.
AC G1RZJ6;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 24-JAN-2024, entry version 69.
DE RecName: Full=Protein-glutamine gamma-glutamyltransferase K {ECO:0000256|ARBA:ARBA00040559};
DE EC=2.3.2.13 {ECO:0000256|ARBA:ARBA00024222};
DE AltName: Full=Epidermal TGase {ECO:0000256|ARBA:ARBA00043229};
DE AltName: Full=Transglutaminase K {ECO:0000256|ARBA:ARBA00041726};
DE AltName: Full=Transglutaminase-1 {ECO:0000256|ARBA:ARBA00041651};
GN Name=TGM1 {ECO:0000313|Ensembl:ENSNLEP00000018673.1};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000018673.1, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000018673.1, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000018673.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC Evidence={ECO:0000256|PIRSR:PIRSR000459-2};
CC Note=Binds 1 Ca(2+) ion per subunit. {ECO:0000256|PIRSR:PIRSR000459-2};
CC -!- SUBUNIT: Interacts with PLAAT4. {ECO:0000256|ARBA:ARBA00038573}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004635}; Lipid-
CC anchor {ECO:0000256|ARBA:ARBA00004635}.
CC -!- SIMILARITY: Belongs to the transglutaminase superfamily.
CC Transglutaminase family. {ECO:0000256|ARBA:ARBA00005968}.
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DR EMBL; ADFV01192214; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003260733.1; XM_003260685.3.
DR AlphaFoldDB; G1RZJ6; -.
DR STRING; 61853.ENSNLEP00000018673; -.
DR Ensembl; ENSNLET00000019607.2; ENSNLEP00000018673.1; ENSNLEG00000015377.2.
DR eggNOG; ENOG502QQ46; Eukaryota.
DR GeneTree; ENSGT01050000244939; -.
DR HOGENOM; CLU_013435_0_2_1; -.
DR InParanoid; G1RZJ6; -.
DR OMA; WSGNYSD; -.
DR TreeFam; TF324278; -.
DR Proteomes; UP000001073; Chromosome 22a.
DR GO; GO:0016020; C:membrane; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003810; F:protein-glutamine gamma-glutamyltransferase activity; IEA:Ensembl.
DR GO; GO:0030216; P:keratinocyte differentiation; IEA:Ensembl.
DR GO; GO:0045787; P:positive regulation of cell cycle; IEA:Ensembl.
DR GO; GO:0010838; P:positive regulation of keratinocyte proliferation; IEA:Ensembl.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR Gene3D; 3.90.260.10; Transglutaminase-like; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR002931; Transglutaminase-like.
DR InterPro; IPR036985; Transglutaminase-like_sf.
DR InterPro; IPR023608; Transglutaminase_animal.
DR InterPro; IPR013808; Transglutaminase_AS.
DR InterPro; IPR008958; Transglutaminase_C.
DR InterPro; IPR036238; Transglutaminase_C_sf.
DR InterPro; IPR001102; Transglutaminase_N.
DR PANTHER; PTHR11590; PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE; 1.
DR PANTHER; PTHR11590:SF49; PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE K; 1.
DR Pfam; PF00927; Transglut_C; 2.
DR Pfam; PF01841; Transglut_core; 1.
DR Pfam; PF00868; Transglut_N; 1.
DR PIRSF; PIRSF000459; TGM_EBP42; 1.
DR SMART; SM00460; TGc; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF49309; Transglutaminase, two C-terminal domains; 2.
DR PROSITE; PS00547; TRANSGLUTAMINASES; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|PIRSR:PIRSR000459-2};
KW Keratinization {ECO:0000256|ARBA:ARBA00023249};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR000459-2};
KW Palmitate {ECO:0000256|ARBA:ARBA00023139};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073}.
FT DOMAIN 360..453
FT /note="Transglutaminase-like"
FT /evidence="ECO:0000259|SMART:SM00460"
FT REGION 1..43
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 62..95
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 788..808
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 71..85
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 368
FT /evidence="ECO:0000256|PIRSR:PIRSR000459-1"
FT ACT_SITE 427
FT /evidence="ECO:0000256|PIRSR:PIRSR000459-1"
FT ACT_SITE 450
FT /evidence="ECO:0000256|PIRSR:PIRSR000459-1"
FT BINDING 490
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR000459-2"
FT BINDING 492
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR000459-2"
FT BINDING 539
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR000459-2"
FT BINDING 544
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR000459-2"
SQ SEQUENCE 808 AA; 89055 MW; B389BA8F249F6EA4 CRC64;
MMDGPRSDVG RWGGNPLQPP TTPSPEPEPE PEPDRRSRRG GGGRSFWARC CGCCSCRNAV
DDDWGPEPSD SRGRGSSSGT RRPVSRGSGV NAAGDGTIRE GMLVVNGVDL LSSRSDQNRR
QHHTEEYEYD ELIVRRGQPF HMLLLLSRTY ESSDRITLEL LIGNNPEVGK GTHVIIPVGK
GGSGGWKAQV VKASGQNLNL RVHTSPNAII GKFQFTVRTQ SDAGEFQLPF DPRNEIYILF
NPWCPEDIVY VDHEDWRQEY VLNESGRIYY GTEAQIGERT WNYGQFDHGV LDACLYILDR
RGMPYGGRGD PVSVSRVISA MVNSLDDNGV LIGTGSGDYS RAPTHQRGGQ REILLSYLRG
LFRPYGQCWV FAGVTTTVLR CLGLATRTVT NFNSAHDTDT SLTMDIYFDE NMKPLEHLNH
DSVWNFHVWN DCWMKRPDLP SGFDGWQVVD ATPQETSSGI FCCGPCSVES IKNGLVYMKY
DTPFIFAEVN SDKVYWQRQD DGSFKIVYVE EKAIGTLIVT KAIGSNMRED ITYLYKHPEG
SDAERKAVET AAAHGSKPNV YANRGSAEDV AMQVEAQDAV MGQDLMVSVM LTNHSSSRRT
VKLHLYLSVT FYTGVSGTIF KETKKEVELA PGASDRVTMP VAYKEYRPHL VDQGAMLLNV
SGHVKESGQV LAKQHTFRLR TPDLSLTLLG AAVVGQECEV QIVFKNPLPV TLTNVVFRLE
GSGLQRPKIL NVGDIGGNET VTLRQTFVPV RPGPRQLIAS LDSPQLSQVH GVIQVDVAPA
PGDRGFFSDA GGDSHLGETI PMASRGGA
//