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Database: UniProt/TrEMBL
Entry: G1SMV5_RABIT
LinkDB: G1SMV5_RABIT
Original site: G1SMV5_RABIT 
ID   G1SMV5_RABIT            Unreviewed;       917 AA.
AC   G1SMV5;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   25-OCT-2017, entry version 42.
DE   SubName: Full=Hexokinase domain containing 1 {ECO:0000313|Ensembl:ENSOCUP00000004278};
GN   Name=HKDC1 {ECO:0000313|Ensembl:ENSOCUP00000004278};
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae;
OC   Oryctolagus.
OX   NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000004278, ECO:0000313|Proteomes:UP000001811};
RN   [1] {ECO:0000313|Ensembl:ENSOCUP00000004278, ECO:0000313|Proteomes:UP000001811}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thorbecke {ECO:0000313|Proteomes:UP000001811};
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J.,
RA   Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E.,
RA   Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J.,
RA   Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S.,
RA   Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I.,
RA   Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I.,
RA   Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J.,
RA   Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D.,
RA   Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L.,
RA   Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S.,
RA   Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G.,
RA   Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K.,
RA   Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T.,
RA   Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J.,
RA   Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S.,
RA   Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29
RT   mammals.";
RL   Nature 478:476-482(2011).
RN   [2] {ECO:0000313|Ensembl:ENSOCUP00000004278}
RP   IDENTIFICATION.
RC   STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000004278};
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the hexokinase family.
CC       {ECO:0000256|SAAS:SAAS00672880}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSOCUP00000004278}.
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DR   EMBL; AAGW02036942; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAGW02036943; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAGW02036944; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAGW02036945; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAGW02036946; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAGW02036947; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAGW02036948; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_002718490.1; XM_002718444.3.
DR   STRING; 9986.ENSOCUP00000004278; -.
DR   Ensembl; ENSOCUT00000004945; ENSOCUP00000004278; ENSOCUG00000004938.
DR   GeneID; 100345105; -.
DR   KEGG; ocu:100345105; -.
DR   CTD; 80201; -.
DR   eggNOG; KOG1369; Eukaryota.
DR   eggNOG; COG5026; LUCA.
DR   GeneTree; ENSGT00390000017159; -.
DR   InParanoid; G1SMV5; -.
DR   KO; K00844; -.
DR   OMA; KIETRHV; -.
DR   OrthoDB; EOG091G08MD; -.
DR   TreeFam; TF314238; -.
DR   Proteomes; UP000001811; Chromosome 18.
DR   Bgee; ENSOCUG00000004938; -.
DR   GO; GO:0005739; C:mitochondrion; IEA:Ensembl.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0005536; F:glucose binding; IEA:InterPro.
DR   GO; GO:0004396; F:hexokinase activity; IEA:InterPro.
DR   GO; GO:0001678; P:cellular glucose homeostasis; IEA:InterPro.
DR   GO; GO:0006096; P:glycolytic process; IEA:UniProtKB-KW.
DR   InterPro; IPR001312; Hexokinase.
DR   InterPro; IPR019807; Hexokinase_BS.
DR   InterPro; IPR022673; Hexokinase_C.
DR   InterPro; IPR022672; Hexokinase_N.
DR   PANTHER; PTHR19443; PTHR19443; 4.
DR   Pfam; PF00349; Hexokinase_1; 2.
DR   Pfam; PF03727; Hexokinase_2; 2.
DR   PROSITE; PS00378; HEXOKINASE_1; 1.
DR   PROSITE; PS51748; HEXOKINASE_2; 2.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|SAAS:SAAS00672869};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001811};
KW   Glycolysis {ECO:0000256|SAAS:SAAS00672870};
KW   Kinase {ECO:0000256|SAAS:SAAS00672871};
KW   Nucleotide-binding {ECO:0000256|SAAS:SAAS00672883};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW   Transferase {ECO:0000256|SAAS:SAAS00672884}.
FT   DOMAIN       22    219       Hexokinase_1. {ECO:0000259|Pfam:PF00349}.
FT   DOMAIN      225    459       Hexokinase_2. {ECO:0000259|Pfam:PF03727}.
FT   DOMAIN      470    666       Hexokinase_1. {ECO:0000259|Pfam:PF00349}.
FT   DOMAIN      672    906       Hexokinase_2. {ECO:0000259|Pfam:PF03727}.
SQ   SEQUENCE   917 AA;  102506 MW;  8547AAE616DDC4EB CRC64;
     MFAVHLMAFY FTKLKEDQIK KVDRFLYHMR LSDETLLDIM ARFQVEMEKG LAKDTNPTAS
     VKMLPTFVRA IPDGSENGEF LALDLGGSKF RVLKVQVSAE GKRSVQMESQ FYPTPNEITR
     GNGSELFEYV ADCLADFMKT KELMHKKLPL GFTFSFPCRQ TKLEEGVLLS WTKKFKARGV
     QDTDVVSRLT QAVKKHKDMD VDILALVNDT VGTMMTCAYD DPYCEVGVII GTGTNACYME
     DMSNIDLVEG DEGRMCINTE WGAFGDDGAL EDIRTEFDRE LDLGSLNPGK QLFEKMISGL
     YLGELVRLIL LKMAKTGLLF GGQKSSALHT KGKIETQHVA AMERYKEGLA NTREILVDLG
     LEPSEADCIA VQHVCTIVSF RSANLCAAAL AAILTRLREN KRLTRLRTTV GMDGTLYKIH
     PQYPKRLHKV VRKLVPNCDV RFLLSESGST KGAAMVTAVA SRVQAQRKQI DEVLALFRLT
     LEQLVGVQDR MRAELEFGLK KKTHPLATVK MLPTYVCGMP DGTEKGKFLA LDLGGTNFRV
     LLVKIRSGRR SVRMYNKIFA IPLEIMQGTG EELFDHIVQC IADFLEYMGL KGARLPLGFT
     FSFPCRQASI DKGTLIGWTK GFKATDCEGE DVVDMLREAI KRRNEFDLDI VAVVNDTVGT
     MMTCGYEDPN CEIGLIAGTG SNMCYMEEMR NIELVEGDEG KMCINTEWGG FGDNGCLDDI
     RTQYDKEVDE GSLNPGKQRY EKMTSGMYLG EIVRQILIGL TKQGLLFRGQ ISERLRTRGI
     FETKFLSQIE SDRLALLQVR RILQQLGLDS TCEDSIVVKE VCGVVSRRAA QLCGAGLAAI
     VEKRREDQGL ERLRITVGVD GTLYKLHPHF SRILQETVKE LAPRCEVTFM LSEDGSGKGA
     ALITAVAKRL QQPRKEN
//
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