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Database: UniProt/TrEMBL
Entry: G1SQQ9_RABIT
LinkDB: G1SQQ9_RABIT
Original site: G1SQQ9_RABIT 
ID   G1SQQ9_RABIT            Unreviewed;      1011 AA.
AC   G1SQQ9;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   20-DEC-2017, entry version 44.
DE   RecName: Full=DNA ligase {ECO:0000256|RuleBase:RU000617};
DE            EC=6.5.1.1 {ECO:0000256|RuleBase:RU000617};
GN   Name=LIG3 {ECO:0000313|Ensembl:ENSOCUP00000005456};
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae;
OC   Oryctolagus.
OX   NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000005456, ECO:0000313|Proteomes:UP000001811};
RN   [1] {ECO:0000313|Ensembl:ENSOCUP00000005456, ECO:0000313|Proteomes:UP000001811}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thorbecke {ECO:0000313|Proteomes:UP000001811};
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J.,
RA   Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E.,
RA   Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J.,
RA   Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S.,
RA   Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I.,
RA   Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I.,
RA   Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J.,
RA   Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D.,
RA   Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L.,
RA   Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S.,
RA   Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G.,
RA   Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K.,
RA   Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T.,
RA   Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J.,
RA   Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S.,
RA   Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29
RT   mammals.";
RL   Nature 478:476-482(2011).
RN   [2] {ECO:0000313|Ensembl:ENSOCUP00000005456}
RP   IDENTIFICATION.
RC   STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000005456};
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY: ATP + (deoxyribonucleotide)(n)-3'-hydroxyl +
CC       5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) +
CC       AMP + diphosphate. {ECO:0000256|RuleBase:RU000617}.
CC   -!- SIMILARITY: Belongs to the ATP-dependent DNA ligase family.
CC       {ECO:0000256|RuleBase:RU004196}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSOCUP00000005456}.
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DR   EMBL; AAGW02039180; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAGW02039181; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_002719278.3; XM_002719232.3.
DR   STRING; 9986.ENSOCUP00000005456; -.
DR   Ensembl; ENSOCUT00000006309; ENSOCUP00000005456; ENSOCUG00000006305.
DR   GeneID; 100344941; -.
DR   KEGG; ocu:100344941; -.
DR   CTD; 3980; -.
DR   eggNOG; KOG4437; Eukaryota.
DR   eggNOG; COG1793; LUCA.
DR   GeneTree; ENSGT00860000133792; -.
DR   InParanoid; G1SQQ9; -.
DR   KO; K10776; -.
DR   OMA; VFDCIYF; -.
DR   OrthoDB; EOG091G0XBU; -.
DR   TreeFam; TF316220; -.
DR   Proteomes; UP000001811; Chromosome 19.
DR   Bgee; ENSOCUG00000006305; -.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:UniProtKB-EC.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006288; P:base-excision repair, DNA ligation; IEA:Ensembl.
DR   GO; GO:0071897; P:DNA biosynthetic process; IEA:InterPro.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   GO; GO:0006302; P:double-strand break repair; IEA:Ensembl.
DR   GO; GO:0090298; P:negative regulation of mitochondrial DNA replication; IEA:Ensembl.
DR   CDD; cd00027; BRCT; 1.
DR   Gene3D; 1.10.3260.10; -; 1.
DR   Gene3D; 3.30.1740.10; -; 1.
DR   Gene3D; 3.40.50.10190; -; 1.
DR   InterPro; IPR001357; BRCT_dom.
DR   InterPro; IPR036420; BRCT_dom_sf.
DR   InterPro; IPR000977; DNA_ligase_ATP-dep.
DR   InterPro; IPR012309; DNA_ligase_ATP-dep_C.
DR   InterPro; IPR012310; DNA_ligase_ATP-dep_cent.
DR   InterPro; IPR016059; DNA_ligase_ATP-dep_CS.
DR   InterPro; IPR012308; DNA_ligase_ATP-dep_N.
DR   InterPro; IPR036599; DNA_ligase_N_sf.
DR   InterPro; IPR031916; LIG3_BRCT.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR001510; Znf_PARP.
DR   InterPro; IPR036957; Znf_PARP_sf.
DR   Pfam; PF04679; DNA_ligase_A_C; 1.
DR   Pfam; PF01068; DNA_ligase_A_M; 1.
DR   Pfam; PF04675; DNA_ligase_A_N; 1.
DR   Pfam; PF16759; LIG3_BRCT; 1.
DR   Pfam; PF00645; zf-PARP; 1.
DR   SMART; SM00292; BRCT; 1.
DR   SMART; SM01336; zf-PARP; 1.
DR   SUPFAM; SSF117018; SSF117018; 1.
DR   SUPFAM; SSF50249; SSF50249; 1.
DR   SUPFAM; SSF52113; SSF52113; 1.
DR   TIGRFAMs; TIGR00574; dnl1; 1.
DR   PROSITE; PS50172; BRCT; 1.
DR   PROSITE; PS00697; DNA_LIGASE_A1; 1.
DR   PROSITE; PS00333; DNA_LIGASE_A2; 1.
DR   PROSITE; PS50160; DNA_LIGASE_A3; 1.
DR   PROSITE; PS00347; PARP_ZN_FINGER_1; 1.
DR   PROSITE; PS50064; PARP_ZN_FINGER_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|RuleBase:RU000617};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001811};
KW   DNA damage {ECO:0000256|RuleBase:RU000617};
KW   DNA recombination {ECO:0000256|RuleBase:RU000617};
KW   DNA repair {ECO:0000256|RuleBase:RU000617};
KW   DNA replication {ECO:0000256|RuleBase:RU000617};
KW   Ligase {ECO:0000256|RuleBase:RU000617};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU000617};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001811}.
FT   DOMAIN       94    186       PARP-type. {ECO:0000259|PROSITE:PS50064}.
FT   DOMAIN      585    719       DNA_LIGASE_A3. {ECO:0000259|PROSITE:
FT                                PS50160}.
FT   DOMAIN      935   1011       BRCT. {ECO:0000259|PROSITE:PS50172}.
FT   COILED      446    466       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1011 AA;  112896 MW;  4E871EB52EE6A4DE CRC64;
     MTVAFKILFP ESLRALGRKE LCLFREQHRW PDLKLFSWWS ETDVLRGRCL LPRRKPVPSF
     GEGRLRARAT CLVFLPGSHV GLCSGPCEMA EQRFCVDYAK RGTAGCKKCK EKIVKGVCRI
     GKVVPNPFSE SGGDMKEWYH IKCMFEKLER ARATTKKIED LTELEGWEEL EDNEKEQITQ
     HITDLSSKAA STPKKKAVVQ AKLTSTGQVT SPVKGASLVT NPNPRKFSGF SAKPNNSGQN
     PPSSPAPTTS LSSSKCDPKH KDCLLREFRK LCAMVADNPS YNTKTQIIQN FLRKGSTGDG
     FRGDTYLTVK LLLPGVIKSV YNLNDKQIVK LFSRIFNCNP DDMARDLEQG DVSETIRVFF
     EQSKSFPPAA KSLLTIQEVD EFLLRLSKLT KEDEQQQALQ DIASRCTAND LKCIIRLIKH
     DLKMNSGAKH VLDALDPNAY EAFKASRNLQ DVVERVLRNE QEVEKEPGCK RALSVQASLM
     TPVQPMLAEA CKSIEYAMKK CPNGMFSEIK YDGERVQVHK NGDHFSYFSR SLKPVLPHKV
     AHFKDYIPQA FPGGHSMILD SEVLLIDNNT GKPLPFGTLG VHKKAAFQDA NVCLFVFDCI
     YFNDVSLMDR PLCERRKLLH DNMVEIPNRI MFSEMKRVTK ASDLADMINR VIREGLEGLV
     LKDVKGTYEP GKRHWLKVKK DYLNEGAMAD TADLVVLGAF YGQGSKGGMM SIFLMGCYDP
     SSQKWCTVTK CAGGHDDATL ARLQKELDMV KISKDPSKIP SWLKINKIYY PDFIVPDPKK
     AAVWEITGAE FSKSEAHTAD GISIRFPRCT RIRDDKDWKS ATNLPQLKEL YQLSKEKADF
     TVVAGDEGSS STGGSSGENE GASGPAVSRK APSKPSASAR KAEGKQSNAN GKGGNKLSTK
     HSPVKLEEKL ARKSSPVKVG EKRKATDEPP CQAKVLLDIF TGVRLYLPPS TPDFSRLRRY
     FVAFNGDLVQ EFDMASATHV LGSRDKNSEA QLVSPEWIWA CIRKRRLVAP C
//
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