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Database: UniProt/TrEMBL
Entry: G1TAG6_RABIT
LinkDB: G1TAG6_RABIT
Original site: G1TAG6_RABIT 
ID   G1TAG6_RABIT            Unreviewed;       638 AA.
AC   G1TAG6;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   30-AUG-2017, entry version 41.
DE   SubName: Full=Proprotein convertase subtilisin/kexin type 2 {ECO:0000313|Ensembl:ENSOCUP00000013658};
GN   Name=PCSK2 {ECO:0000313|Ensembl:ENSOCUP00000013658};
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae;
OC   Oryctolagus.
OX   NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000013658, ECO:0000313|Proteomes:UP000001811};
RN   [1] {ECO:0000313|Ensembl:ENSOCUP00000013658, ECO:0000313|Proteomes:UP000001811}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thorbecke {ECO:0000313|Proteomes:UP000001811};
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J.,
RA   Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E.,
RA   Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J.,
RA   Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S.,
RA   Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I.,
RA   Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I.,
RA   Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J.,
RA   Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D.,
RA   Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L.,
RA   Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S.,
RA   Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G.,
RA   Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K.,
RA   Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T.,
RA   Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J.,
RA   Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S.,
RA   Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29
RT   mammals.";
RL   Nature 478:476-482(2011).
RN   [2] {ECO:0000313|Ensembl:ENSOCUP00000013658}
RP   IDENTIFICATION.
RC   STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000013658};
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the peptidase S8 family.
CC       {ECO:0000256|RuleBase:RU003355, ECO:0000256|SAAS:SAAS00679558}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSOCUP00000013658}.
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DR   EMBL; AAGW02052478; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAGW02052479; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAGW02052480; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAGW02052481; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAGW02052482; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAGW02052483; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAGW02052484; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAGW02052485; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAGW02052486; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAGW02052487; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_002711007.1; XM_002710961.3.
DR   ProteinModelPortal; G1TAG6; -.
DR   STRING; 9986.ENSOCUP00000013658; -.
DR   MEROPS; S08.073; -.
DR   Ensembl; ENSOCUT00000015895; ENSOCUP00000013658; ENSOCUG00000015893.
DR   GeneID; 100358339; -.
DR   KEGG; ocu:100358339; -.
DR   CTD; 5126; -.
DR   eggNOG; KOG3525; Eukaryota.
DR   eggNOG; KOG3526; Eukaryota.
DR   eggNOG; COG1404; LUCA.
DR   eggNOG; COG4935; LUCA.
DR   GeneTree; ENSGT00750000117358; -.
DR   InParanoid; G1TAG6; -.
DR   KO; K01360; -.
DR   OMA; PQRGVLK; -.
DR   OrthoDB; EOG091G05HI; -.
DR   TreeFam; TF314277; -.
DR   Proteomes; UP000001811; Chromosome 4.
DR   Bgee; ENSOCUG00000015893; -.
DR   GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR   GO; GO:0016020; C:membrane; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:Ensembl.
DR   GO; GO:0034230; P:enkephalin processing; IEA:Ensembl.
DR   GO; GO:0030070; P:insulin processing; IEA:Ensembl.
DR   GO; GO:0007399; P:nervous system development; IEA:Ensembl.
DR   GO; GO:0016540; P:protein autoprocessing; IEA:Ensembl.
DR   CDD; cd04059; Peptidases_S8_Protein_converta; 1.
DR   Gene3D; 2.60.120.260; -; 1.
DR   Gene3D; 3.40.50.200; -; 1.
DR   InterPro; IPR008979; Galactose-bd-like.
DR   InterPro; IPR034182; Kexin/furin.
DR   InterPro; IPR009020; Peptidase/Inhibitor_I9.
DR   InterPro; IPR000209; Peptidase_S8/S53_dom.
DR   InterPro; IPR023827; Peptidase_S8_Asp-AS.
DR   InterPro; IPR022398; Peptidase_S8_His-AS.
DR   InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR   InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR   InterPro; IPR002884; PrprotnconvertsP.
DR   InterPro; IPR032815; S8_pro-domain.
DR   Pfam; PF01483; P_proprotein; 1.
DR   Pfam; PF00082; Peptidase_S8; 1.
DR   Pfam; PF16470; S8_pro-domain; 1.
DR   PRINTS; PR00723; SUBTILISIN.
DR   SUPFAM; SSF49785; SSF49785; 1.
DR   SUPFAM; SSF52743; SSF52743; 1.
DR   SUPFAM; SSF54897; SSF54897; 1.
DR   PROSITE; PS00136; SUBTILASE_ASP; 1.
DR   PROSITE; PS00137; SUBTILASE_HIS; 1.
DR   PROSITE; PS00138; SUBTILASE_SER; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001811};
KW   Hydrolase {ECO:0000256|RuleBase:RU003355,
KW   ECO:0000256|SAAS:SAAS00066207};
KW   Protease {ECO:0000256|RuleBase:RU003355,
KW   ECO:0000256|SAAS:SAAS00066236};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW   Serine protease {ECO:0000256|RuleBase:RU003355,
KW   ECO:0000256|SAAS:SAAS00066164}; Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     23       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        24    638       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003423064.
FT   DOMAIN       33    109       S8_pro-domain. {ECO:0000259|Pfam:
FT                                PF16470}.
FT   DOMAIN      158    420       Peptidase S8. {ECO:0000259|Pfam:PF00082}.
FT   DOMAIN      504    590       P_proprotein. {ECO:0000259|Pfam:PF01483}.
SQ   SEQUENCE   638 AA;  70499 MW;  4A7CBA63D8CE079D CRC64;
     MQGGSISRWQ AAAGLLLCAT VFASSERAVF TNHFLVELHK GGEEEARQVA AEHGFGVRKL
     PFTDGLYHFY HNGLAKAKRR RSLHHKQQLE RDPRVKMALQ QEGFDRKKRG YRDINEIDIN
     MNDPLFTKQW YLINTGQADG TPGLDLNVAE AWELGYTGKG VTIGIMDDGI DYLHPDLASN
     YNAEASYDFS SNDPYPYPRY TDDWFNSHGT RCAGEVSAAA NNNICGVGVA YNSKVAGIRM
     LDQPFMTDII EASSISHMPQ LIDIYSASWG PTDNGKTVDG PRELTLQAMA DGVNKGRGGK
     GSIYVWASGD GGSYDDCNCD GYASSMWTIS INSAINDGRT ALYDESCSST LASTFSNGRK
     RNPEAGVATT DLYGNCTLRH SGTSAAAPEA AGVFALALEA NLGLTWRDMQ HLTVLTSKRN
     QLHDEVHQWR RNGVGLEFNH LFGYGVLDAG AMVKMAKDWK TVPERFHCVG GSVQDPEKIP
     PTGKLVLTLT TDACEGKENF VRYLEHVQAV ITVNATRRGD LNINMTSPMG TKSILLSRRP
     RDDDSKVGFD KWPFMTTHTW GEDARGTWTL ELGFVGSTPQ KGVLKEWTLM LHGTQSAPYI
     DQVVRDYQSK LAMSKKEELE EELDEAVERS LQSILSKN
//
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