ID G1TEQ3_RABIT Unreviewed; 1066 AA.
AC G1TEQ3;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 2.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=Pumilio RNA binding family member 2 {ECO:0000313|Ensembl:ENSOCUP00000015387.3};
GN Name=PUM2 {ECO:0000313|Ensembl:ENSOCUP00000015387.3};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000015387.3, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000015387.3, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000015387.3,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000015387.3}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000015387.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic granule
CC {ECO:0000256|ARBA:ARBA00004463}.
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DR EMBL; AAGW02055037; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02055038; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_017196391.1; XM_017340902.1.
DR AlphaFoldDB; G1TEQ3; -.
DR SMR; G1TEQ3; -.
DR STRING; 9986.ENSOCUP00000015387; -.
DR PaxDb; 9986-ENSOCUP00000015387; -.
DR Ensembl; ENSOCUT00000017909.4; ENSOCUP00000015387.3; ENSOCUG00000017908.4.
DR eggNOG; KOG1488; Eukaryota.
DR GeneTree; ENSGT00940000157575; -.
DR HOGENOM; CLU_004017_0_0_1; -.
DR InParanoid; G1TEQ3; -.
DR OMA; XPAVVPP; -.
DR OrthoDB; 5472666at2759; -.
DR TreeFam; TF318160; -.
DR Proteomes; UP000001811; Chromosome 2.
DR Bgee; ENSOCUG00000017908; Expressed in upper lobe of left lung and 15 other cell types or tissues.
DR GO; GO:0010494; C:cytoplasmic stress granule; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0031965; C:nuclear membrane; IEA:Ensembl.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
DR GO; GO:0106222; F:lncRNA binding; IEA:Ensembl.
DR GO; GO:0035198; F:miRNA binding; IEA:Ensembl.
DR GO; GO:0003730; F:mRNA 3'-UTR binding; IEA:Ensembl.
DR GO; GO:0062104; F:pumilio-response element binding; IEA:Ensembl.
DR GO; GO:0060612; P:adipose tissue development; IEA:Ensembl.
DR GO; GO:0051276; P:chromosome organization; IEA:Ensembl.
DR GO; GO:0001942; P:hair follicle development; IEA:Ensembl.
DR GO; GO:0035196; P:miRNA processing; IEA:Ensembl.
DR GO; GO:0007005; P:mitochondrion organization; IEA:Ensembl.
DR GO; GO:2000637; P:positive regulation of miRNA-mediated gene silencing; IEA:Ensembl.
DR GO; GO:1900246; P:positive regulation of RIG-I signaling pathway; IEA:Ensembl.
DR GO; GO:0051983; P:regulation of chromosome segregation; IEA:Ensembl.
DR GO; GO:0043488; P:regulation of mRNA stability; IEA:Ensembl.
DR GO; GO:0022904; P:respiratory electron transport chain; IEA:Ensembl.
DR GO; GO:0001501; P:skeletal system development; IEA:Ensembl.
DR GO; GO:0034063; P:stress granule assembly; IEA:Ensembl.
DR CDD; cd07920; Pumilio; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR033133; PUM-HD.
DR InterPro; IPR033712; Pumilio_RNA-bd.
DR InterPro; IPR001313; Pumilio_RNA-bd_rpt.
DR PANTHER; PTHR12537:SF52; PUMILIO HOMOLOG 2; 1.
DR PANTHER; PTHR12537; RNA BINDING PROTEIN PUMILIO-RELATED; 1.
DR Pfam; PF00806; PUF; 8.
DR SMART; SM00025; Pumilio; 8.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS50302; PUM; 8.
DR PROSITE; PS50303; PUM_HD; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 708..1048
FT /note="PUM-HD"
FT /evidence="ECO:0000259|PROSITE:PS50303"
FT REPEAT 728..763
FT /note="Pumilio"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00317"
FT REPEAT 764..799
FT /note="Pumilio"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00317"
FT REPEAT 800..835
FT /note="Pumilio"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00317"
FT REPEAT 836..871
FT /note="Pumilio"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00317"
FT REPEAT 872..907
FT /note="Pumilio"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00317"
FT REPEAT 908..943
FT /note="Pumilio"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00317"
FT REPEAT 944..979
FT /note="Pumilio"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00317"
FT REPEAT 980..1022
FT /note="Pumilio"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00317"
FT REGION 106..208
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 493..554
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 622..652
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 106..157
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1066 AA; 114268 MW; 0BBF7A6289D7EA97 CRC64;
MNHDFQALAL ESRGMGELLP TKKFWEPDDS TKDGQKGIFL GDDEWRETAW GTSHHSMSQP
IMVQRRSGQG FHGNSEVNAI LSPRSESGGL GVSMVEYVLS SSPADKLDSR FRKGTFGTRD
AETDGPEKGD QKGKASPFEE DQNRDLKQGD DDDSKINGRG LPNGMDADCK DFNRTPGSRQ
ASPTEVVERL GPSTNPPEGL GPLPNPTTNK PLVEDFSNPE TQNLDAMEQV GLDSLQFDYP
GNQVPMDSSG ATVGLFDYNS QQQLFQRTNA LTVQQLTAAQ QQQYALAAAQ QPHIAGVFSA
GLAPAAFVPN PYIISAAPPG TDPYTAAGLA AAATLAGPAV VPPQYYGVPW GVYPANLFQQ
QAAAAANNTA SQQAASQAQP GQQQVLRAGA GQRPLTPSQG QQGQQAESLA AAAAANPTLA
FGQSLATGMP GYQVLAPTAY YDQTGALVVG PGARTGLGTP VRLMAPTPVL ISSAAAQAAA
AAAAAGGTAN SLTGSTNGLF RPIGTQPPQQ QQQQQPSTNL QSNSFYGSNS LTNSSQSSSL
FSHGPGQPGS TSLGFGSSSS LGAAIGSALS GFGSSVGSSA SSSATRRESL STSSDLYKRS
SSSLAPIGQP FYNSLGFSSS PSPIGMPLPS QTPGHSLTPP PSLSSHGSSS SLHLGGLTNG
SGRYISAAPG AEAKYRSASS TSSLFSSSSQ LFPPSRLRYN RSDIMPSGRS RLLEDFRNNR
FPNLQLRDLI GHIVEFSQDQ HGSRFIQQKL ERATPAERQM VFNEILQAAY QLMTDVFGNY
VIQKFFEFGS LDQKLALATR IRGHVLPLAL QMYGCRVIQK ALESISSDQQ SEMVKELDGH
VLKCVKDQNG NHVVQKCIEC VQPQSLQFII DAFKGQVFVL STHPYGCRVI QRILEHCTAE
QTLPILEELH QHTEQLVQDQ YGNYVIQHVL EHGRPEDKSK IVSEIRGKVL ALSQHKFASN
VVEKCVTHAS RAERALLIDE VCCQSDGPHS ALYTMMKDQY ANYVVQKMID MAEPAQRKII
MHKIRPHITT LRKYTYGKHI LAKLEKYYLK NSPDLGPIGG PPNGML
//
