ID G2N9D5_9ACTO Unreviewed; 335 AA.
AC G2N9D5;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 03-APR-2013, entry version 12.
DE RecName: Full=Aspartate carbamoyltransferase;
DE EC=2.1.3.2;
DE AltName: Full=Aspartate transcarbamylase;
GN Name=pyrB; ORFNames=SACTE_0891;
OS Streptomyces sp. SirexAA-E.
OC Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC Streptomycineae; Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=862751;
RN [1]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=SirexAA-E;
RG US DOE Joint Genome Institute;
RA Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA Peters L., Ovchinnikova G., Davenport K., Detter J.C., Han C.,
RA Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Pagani I.,
RA Adams A., Raffa K., Adams S., Book A., Currie C., Woyke T.;
RT "Complete sequence of Streptomyces sp. SirexAA-E.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY: Carbamoyl phosphate + L-aspartate = phosphate
CC + N-carbamoyl-L-aspartate.
CC -!- PATHWAY: Pyrimidine metabolism; UMP biosynthesis via de novo
CC pathway; (S)-dihydroorotate from bicarbonate: step 2/3.
CC -!- SIMILARITY: Belongs to the ATCase/OTCase family.
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DR EMBL; CP002993; AEN08820.1; -; Genomic_DNA.
DR RefSeq; YP_004801360.1; NC_015953.1.
DR ProteinModelPortal; G2N9D5; -.
DR EnsemblBacteria; AEN08820; AEN08820; SACTE_0891.
DR GeneID; 11103393; -.
DR KEGG; ssx:SACTE_0891; -.
DR KO; K00609; -.
DR UniPathway; UPA00070; UER00116.
DR GO; GO:0016597; F:amino acid binding; IEA:InterPro.
DR GO; GO:0004070; F:aspartate carbamoyltransferase activity; IEA:HAMAP.
DR GO; GO:0006207; P:'de novo' pyrimidine nucleobase biosynthetic process; IEA:InterPro.
DR GO; GO:0044205; P:'de novo' UMP biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0006520; P:cellular amino acid metabolic process; IEA:InterPro.
DR HAMAP; MF_00001; Asp_carb_tr; 1; -.
DR InterPro; IPR006132; Asp/Orn_carbamoyltranf_P-bd.
DR InterPro; IPR006130; Asp/Orn_carbamoylTrfase.
DR InterPro; IPR002082; Asp_carbamoyltransf.
DR InterPro; IPR006131; Asp_carbamoyltransf_Asp/Orn-bd.
DR Pfam; PF00185; OTCace; 1.
DR Pfam; PF02729; OTCace_N; 1.
DR PRINTS; PR00100; AOTCASE.
DR PRINTS; PR00101; ATCASE.
DR SUPFAM; SSF53671; Asp/Orn_carbamoyltranf; 1.
DR TIGRFAMs; TIGR00670; asp_carb_tr; 1.
DR PROSITE; PS00097; CARBAMOYLTRANSFERASE; 1.
PE 3: Inferred from homology;
KW Pyrimidine biosynthesis; Transferase.
SQ SEQUENCE 335 AA; 36035 MW; 31AD7AF45010CA9A CRC64;
MLRSPGGNPR HLISAADLTR DDAVLILDTA EEMARVADRP IKKLPTLRGR TVVNLFFEDS
TRTRISFEAA AKRLSADVIN FSAKGSSVSK GESLKDTALT LEAMGADAVV IRHGSSGAPY
RLATSGWIDG AVVNAGDGTH EHPTQALLDA FTIRRRLVGA DAGLGKDLDG RRVTIVGDIL
HSRVARSNVH LLTTLGAQVT LVAPPTLVPV GVERWPCEVS YSLDDVLPAS DAVMMLRVQR
ERMNAAYFPT EREYSRRYGL DGLRMAKMPE HAVVMHPGPM NRGMEITAEV ADSGRCTAVE
QVANGVSVRM AVLYLLLGGS ETALPSAAAR TEENK
//
