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Database: UniProt/TrEMBL
Entry: G2NBJ9_9ACTO
LinkDB: G2NBJ9_9ACTO
Original site: G2NBJ9_9ACTO 
ID   G2NBJ9_9ACTO            Unreviewed;       269 AA.
AC   G2NBJ9;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   19-FEB-2014, entry version 19.
DE   RecName: Full=Indole-3-glycerol phosphate synthase;
DE            Short=IGPS;
DE            EC=4.1.1.48;
GN   Name=trpC; ORFNames=SACTE_1463;
OS   Streptomyces sp. SirexAA-E.
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Streptomycineae; Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=862751;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=SirexAA-E;
RG   US DOE Joint Genome Institute;
RA   Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA   Peters L., Ovchinnikova G., Davenport K., Detter J.C., Han C.,
RA   Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Pagani I.,
RA   Adams A., Raffa K., Adams S., Book A., Currie C., Woyke T.;
RT   "Complete sequence of Streptomyces sp. SirexAA-E.";
RL   Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-
CC       phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO(2) + H(2)O.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-tryptophan biosynthesis; L-
CC       tryptophan from chorismate: step 4/5.
CC   -!- SIMILARITY: Belongs to the TrpC family.
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DR   EMBL; CP002993; AEN09380.1; -; Genomic_DNA.
DR   RefSeq; YP_004801920.1; NC_015953.1.
DR   ProteinModelPortal; G2NBJ9; -.
DR   EnsemblBacteria; AEN09380; AEN09380; SACTE_1463.
DR   GeneID; 11098326; -.
DR   KEGG; ssx:SACTE_1463; -.
DR   KO; K01609; -.
DR   BioCyc; SSP862751:GHMW-1479-MONOMER; -.
DR   UniPathway; UPA00035; UER00043.
DR   GO; GO:0004425; F:indole-3-glycerol-phosphate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0000162; P:tryptophan biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.20.20.70; -; 1.
DR   HAMAP; MF_00134_A; IGPS_A; 1.
DR   HAMAP; MF_00134_B; IGPS_B; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR013798; Indole-3-glycerol_P_synth.
DR   InterPro; IPR001468; Indole-3-GlycerolPSynthase_CS.
DR   InterPro; IPR011060; RibuloseP-bd_barrel.
DR   Pfam; PF00218; IGPS; 1.
DR   SUPFAM; SSF51366; SSF51366; 1.
DR   PROSITE; PS00614; IGPS; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Aromatic amino acid biosynthesis;
KW   Complete proteome; Decarboxylase; Lyase; Tryptophan biosynthesis.
SQ   SEQUENCE   269 AA;  28255 MW;  95C75A78574E5E85 CRC64;
     MSVLDEIIDG VRADLAERQA RVSLDELKER AARAPQAKDG VAALRGEGVT VICEVKRSSP
     SKGALAAIAD PAALAADYEA GGASVISVLT EERRFGGSLA DLEAVRAKVD IPVLRKDFIV
     TSYQLWEARA YGADLALLIV AALDQEALVS LIERAESIGL TPLVEAHDEE EAERAVDAGA
     KIIGVNARNL KDLKVDRSTF ERVAPEIPDH IVKVAESGVR GPHDLIAYAN AGADAVLVGE
     SLVTGRDPRA AVADLVAAGA HPALRHGRG
//
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