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Database: UniProt/TrEMBL
Entry: G2NMP0_STREK
LinkDB: G2NMP0_STREK
Original site: G2NMP0_STREK 
ID   G2NMP0_STREK            Unreviewed;       739 AA.
AC   G2NMP0;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   07-JUN-2017, entry version 35.
DE   SubName: Full=Isocitrate dehydrogenase, NADP-dependent {ECO:0000313|EMBL:AEN13410.1};
DE            EC=1.1.1.42 {ECO:0000313|EMBL:AEN13410.1};
GN   ORFNames=SACTE_5619 {ECO:0000313|EMBL:AEN13410.1};
OS   Streptomyces sp. (strain SirexAA-E / ActE).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=862751 {ECO:0000313|EMBL:AEN13410.1, ECO:0000313|Proteomes:UP000001397};
RN   [1] {ECO:0000313|EMBL:AEN13410.1, ECO:0000313|Proteomes:UP000001397}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SirexAA-E / ActE {ECO:0000313|Proteomes:UP000001397};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA   Peters L., Ovchinnikova G., Davenport K., Detter J.C., Han C.,
RA   Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Pagani I.,
RA   Adams A., Raffa K., Adams S., Book A., Currie C., Woyke T.;
RT   "Complete sequence of Streptomyces sp. SirexAA-E.";
RL   Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Note=Binds 1 Mg(2+) or Mn(2+) ion per subunit.
CC       {ECO:0000256|PIRSR:PIRSR009407-3};
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DR   EMBL; CP002993; AEN13410.1; -; Genomic_DNA.
DR   RefSeq; WP_014049360.1; NC_015953.1.
DR   STRING; 862751.SACTE_5619; -.
DR   EnsemblBacteria; AEN13410; AEN13410; SACTE_5619.
DR   KEGG; ssx:SACTE_5619; -.
DR   PATRIC; fig|862751.12.peg.5829; -.
DR   eggNOG; COG2838; LUCA.
DR   KO; K00031; -.
DR   OrthoDB; POG091H0B3N; -.
DR   BioCyc; SSP862751:GHMW-5526-MONOMER; -.
DR   Proteomes; UP000001397; Chromosome.
DR   GO; GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR   InterPro; IPR004436; Isocitrate_DH_NADP_mono.
DR   Pfam; PF03971; IDH; 1.
DR   PIRSF; PIRSF009407; IDH_monmr; 1.
DR   TIGRFAMs; TIGR00178; monomer_idh; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001397};
KW   Magnesium {ECO:0000256|PIRSR:PIRSR009407-3};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR009407-3};
KW   Oxidoreductase {ECO:0000313|EMBL:AEN13410.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001397}.
FT   REGION      132    139       Substrate binding. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   METAL       348    348       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       546    546       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       550    550       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   BINDING     145    145       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   BINDING     545    545       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   SITE        255    255       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
FT   SITE        418    418       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
SQ   SEQUENCE   739 AA;  79068 MW;  FA1E9D5001C22724 CRC64;
     MTDSTIIYTH TDEAPALATY SFLPVVEAYA STAGVTVESR DISLAGRIIA SFPERLKADQ
     RIDDALAELG ELAKAPGANI IKLPNISASI PQLKAAIAEL QEQGYALPDY PDDPKTDEDK
     DVRARYDKVK GSAVNPVLRE GNSDRRAPAS VKNYAKTHPH RMGAWTADSK TNVATMGVDD
     FRSTEKSAVV TEPGNLRIEL VGDDGTTTVL RESVPVLAGE VVDAAVLRVA ALREFITAQI
     ARAKAEGVLF SVHLKATMMK VSDPIIFGHV VRAFFPKTFA AYGDVLAAAG LTPNDGLGGI
     LKGLESLPEG AKIKESFEAE LAEGPALAMV DSDKGITNLH VPSDVIVDAS MPAMIRTSGH
     MWGPDGDEAD TIAVLPDSSY AGVYQVVIDD CRANGAFDPS TMGSVPNVGL MAQKAEEYGS
     HDKTFEIPAT GTVRVVDAAG NAVLEQAVGA GDIFRMCQTK DLPIQDWVKL AVTRARATGN
     PAVFWLDEDR AHDAKLIEKV KTYLADHDTD GLQIEIMTPE KATAFSLERI RRGEDTISVT
     GNVLRDYLTD LFPILELGTS AKMLSVVPLM NGGGLFETGA GGSAPKHVQQ LVKEDYLRWD
     SLGEFLALAV SFEHLAQTTG NARAQVLADT LDRATATFLN EDKSPSRRLG GIDNRGSHFY
     LALYWAQELA RQTEDAKLAE AFAALAKTLA EQEQTIVDEL VAVQGKPADI GGYYQPDPAK
     AAAVMRPSAT FNAAVASLS
//
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