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Database: UniProt/TrEMBL
Entry: G2PD11_STRVO
LinkDB: G2PD11_STRVO
Original site: G2PD11_STRVO 
ID   G2PD11_STRVO            Unreviewed;       739 AA.
AC   G2PD11;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   05-JUL-2017, entry version 35.
DE   SubName: Full=Isocitrate dehydrogenase, NADP-dependent {ECO:0000313|EMBL:AEM82637.1};
GN   ORFNames=Strvi_2940 {ECO:0000313|EMBL:AEM82637.1};
OS   Streptomyces violaceusniger Tu 4113.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=653045 {ECO:0000313|EMBL:AEM82637.1, ECO:0000313|Proteomes:UP000008703};
RN   [1] {ECO:0000313|EMBL:AEM82637.1, ECO:0000313|Proteomes:UP000008703}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tu 4133 {ECO:0000313|Proteomes:UP000008703};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA   Peters L., Ivanova N., Daligault H., Detter J.C., Han C., Tapia R.,
RA   Land M., Hauser L., Kyrpides N., Ivanova N., Pagani I., Hagen A.,
RA   Katz L., Fiedler H.-P., Keasling J., Fortman J., Woyke T.;
RT   "Complete sequence of chromosome of Streptomyces violaceusniger Tu
RT   4113.";
RL   Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Note=Binds 1 Mg(2+) or Mn(2+) ion per subunit.
CC       {ECO:0000256|PIRSR:PIRSR009407-3};
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DR   EMBL; CP002994; AEM82637.1; -; Genomic_DNA.
DR   RefSeq; WP_014056139.1; NC_015957.1.
DR   ProteinModelPortal; G2PD11; -.
DR   STRING; 653045.Strvi_2940; -.
DR   EnsemblBacteria; AEM82637; AEM82637; Strvi_2940.
DR   GeneID; 32484120; -.
DR   KEGG; svl:Strvi_2940; -.
DR   eggNOG; ENOG4105E9K; Bacteria.
DR   eggNOG; COG2838; LUCA.
DR   KO; K00031; -.
DR   OrthoDB; POG091H0B3N; -.
DR   BioCyc; SVIO653045:GHK6-2637-MONOMER; -.
DR   Proteomes; UP000008703; Chromosome.
DR   GO; GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR   InterPro; IPR004436; Isocitrate_DH_NADP_mono.
DR   Pfam; PF03971; IDH; 1.
DR   PIRSF; PIRSF009407; IDH_monmr; 1.
DR   TIGRFAMs; TIGR00178; monomer_idh; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000008703};
KW   Magnesium {ECO:0000256|PIRSR:PIRSR009407-3};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR009407-3};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008703}.
FT   REGION      132    139       Substrate binding. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   METAL       348    348       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       546    546       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       550    550       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   BINDING     145    145       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   BINDING     545    545       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   SITE        255    255       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
FT   SITE        418    418       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
SQ   SEQUENCE   739 AA;  79084 MW;  98FCF639AA807109 CRC64;
     MTDSTIIYTH TDEAPALATY SFLPVIEAYA STAGVTVESR DISLAGRIIA QFPEYLEEGQ
     RIPDALAELG DLAKTPEANI IKLPNISASI PQLKAAVAEL QEQGYALPDY PDDPKTDEER
     EIRARYDKVK GSAVNPVLRE GNSDRRAPAS VKNYAKANPH RMGAWTADSK TNVAHMDTDD
     FRATEKSAVI QEAGSLRIEL AGDDGSTTVL RESVPVLAGE VVDASVMRVA ALREFLSAQV
     GRAKAEGVLF SLHLKATMMK VSDPIVFGHA VRAFFPKTFA EHGEALAAAG LTPNDGLGGI
     LKGLESLPEG AAIKASFDTE LAEGPELAMV DSDRGITNLH VPSDVIVDAS MPAMIRTSGH
     MWGPDGEEHD TLAVIPDSSY AGIYQAVLDD CRANGAFDPA TMGSVPNVGL MAQKAEEYGS
     HDKTFEIPTT GTVRVLDEAG NAVLEQVVGA GDIFRMCQTK DVPIKDWVKL AVTRARATGD
     PAVFWLDEGR AHDANLIEKV KAYLPEHDTE GLDIKILSPV EAIKLSLERI RRGENTISVT
     GNVLRDYLTD LFPILELGTS AKMLSVVPLI NGGGLFETGA GGSAPKHVQQ LVKENYLRWD
     SLGEFLALAV SFEHLAQKTG NARAQVLADT LDRATGTFLA ENKSPSRRVG GIDNRGSHFY
     LARYWAQELA GQTDDAALAK AFAPLAEVLT AQEQTIVDEL IAVQGSPADI GGYYQPDAAK
     AAAVMRPSAT FNQALATLG
//
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