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Database: UniProt/TrEMBL
Entry: G3GJ67_MUSDO
LinkDB: G3GJ67_MUSDO
Original site: G3GJ67_MUSDO 
ID   G3GJ67_MUSDO            Unreviewed;       214 AA.
AC   G3GJ67;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   30-AUG-2017, entry version 31.
DE   RecName: Full=Superoxide dismutase {ECO:0000256|RuleBase:RU000414};
DE            EC=1.15.1.1 {ECO:0000256|RuleBase:RU000414};
GN   Name=SOD2 {ECO:0000313|EMBL:AEO50701.1};
GN   Synonyms=101887840 {ECO:0000313|VectorBase:MDOA007183-PB};
OS   Musca domestica (House fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
OC   Muscoidea; Muscidae; Musca.
OX   NCBI_TaxID=7370 {ECO:0000313|EMBL:AEO50701.1};
RN   [1] {ECO:0000313|EMBL:AEO50701.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=22750315; DOI=10.1016/j.gene.2012.06.025;
RA   Tang T., Huang D.W., Zhou C.Q., Li X., Xie Q.J., Liu F.S.;
RT   "Molecular cloning and expression patterns of copper/zinc superoxide
RT   dismutase and manganese superoxide dismutase in Musca domestica.";
RL   Gene 505:211-220(2012).
RN   [2] {ECO:0000313|EMBL:AFP59144.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=ALHF {ECO:0000313|EMBL:AFP59144.1};
RC   TISSUE=Whole body {ECO:0000313|EMBL:AFP59144.1};
RA   Liu N., Zhang L., Li M., Reid W.;
RT   "Transcriptome of adult Musca domestica launches a platform for
RT   comparative house fly gene expression and characterization of
RT   differential gene expression among resistant and susceptible house
RT   flies.";
RL   Submitted (AUG-2012) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Proteomes:UP000095301, ECO:0000313|VectorBase:MDOA007183-PB}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Aabys {ECO:0000313|Proteomes:UP000095301,
RC   ECO:0000313|VectorBase:MDOA007183-PB};
RX   PubMed=25315136; DOI=10.1186/s13059-014-0466-3;
RA   Scott J.G., Warren W.C., Beukeboom L.W., Bopp D., Clark A.G.,
RA   Giers S.D., Hediger M., Jones A.K., Kasai S., Leichter C.A., Li M.,
RA   Meisel R.P., Minx P., Murphy T.D., Nelson D.R., Reid W.R.,
RA   Rinkevich F.D., Robertson H.M., Sackton T.B., Sattelle D.B.,
RA   Thibaud-Nissen F., Tomlinson C., van de Zande L., Walden K.K.,
RA   Wilson R.K., Liu N.;
RT   "Genome of the house fly, Musca domestica L., a global vector of
RT   diseases with adaptations to a septic environment.";
RL   Genome Biol. 15:RESEARCH0466.1-RESEARCH0466.16(2014).
RN   [4] {ECO:0000313|VectorBase:MDOA007183-PB}
RP   IDENTIFICATION.
RC   STRAIN=Aabys {ECO:0000313|VectorBase:MDOA007183-PB};
RG   VectorBase;
RL   Submitted (NOV-2016) to UniProtKB.
CC   -!- FUNCTION: Destroys radicals which are normally produced within the
CC       cells and which are toxic to biological systems.
CC       {ECO:0000256|RuleBase:RU000414}.
CC   -!- CATALYTIC ACTIVITY: 2 superoxide + 2 H(+) = O(2) + H(2)O(2).
CC       {ECO:0000256|RuleBase:RU000414}.
CC   -!- SIMILARITY: Belongs to the iron/manganese superoxide dismutase
CC       family. {ECO:0000256|RuleBase:RU000414}.
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DR   EMBL; JF919739; AEO50701.1; -; mRNA.
DR   EMBL; KA644515; AFP59144.1; -; mRNA.
DR   RefSeq; NP_001273816.1; NM_001286887.1.
DR   GeneID; 101887840; -.
DR   KEGG; mde:101887840; -.
DR   VectorBase; MDOA007183-RB; MDOA007183-PB; MDOA007183.
DR   CTD; 6648; -.
DR   KO; K04564; -.
DR   Proteomes; UP000095301; Whole Genome Shotgun Assembly.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004784; F:superoxide dismutase activity; IEA:UniProtKB-EC.
DR   InterPro; IPR001189; Mn/Fe_SOD.
DR   InterPro; IPR019833; Mn/Fe_SOD_BS.
DR   InterPro; IPR019832; Mn/Fe_SOD_C.
DR   InterPro; IPR019831; Mn/Fe_SOD_N.
DR   Pfam; PF02777; Sod_Fe_C; 1.
DR   Pfam; PF00081; Sod_Fe_N; 1.
DR   PIRSF; PIRSF000349; SODismutase; 1.
DR   PRINTS; PR01703; MNSODISMTASE.
DR   SUPFAM; SSF46609; SSF46609; 1.
DR   SUPFAM; SSF54719; SSF54719; 1.
DR   PROSITE; PS00088; SOD_MN; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000095301};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR000349-1,
KW   ECO:0000256|RuleBase:RU000414};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU000414};
KW   Reference proteome {ECO:0000313|Proteomes:UP000095301}.
FT   DOMAIN       19     99       Sod_Fe_N. {ECO:0000259|Pfam:PF00081}.
FT   DOMAIN      106    209       Sod_Fe_C. {ECO:0000259|Pfam:PF02777}.
FT   COILED       49     76       {ECO:0000256|SAM:Coils}.
FT   METAL        44     44       Divalent metal cation.
FT                                {ECO:0000256|PIRSR:PIRSR000349-1}.
FT   METAL        92     92       Divalent metal cation.
FT                                {ECO:0000256|PIRSR:PIRSR000349-1}.
FT   METAL       176    176       Divalent metal cation.
FT                                {ECO:0000256|PIRSR:PIRSR000349-1}.
FT   METAL       180    180       Divalent metal cation.
FT                                {ECO:0000256|PIRSR:PIRSR000349-1}.
SQ   SEQUENCE   214 AA;  24234 MW;  4F057C0786FE2C40 CRC64;
     MFALSRNVSN VAKNAVRGKH TLPKLPYDYA ALEPIVCREI MELHHTKHHQ TYVNNLNAAE
     EQLAEAQSKN DVTKIISLAP ALRFNGGGHI NHSIFWQNLT SERTEPSADL KKAIESQWKS
     LDAFKKEMTA LTVAVQGSGW GWLGYNKKTQ KLQIVAMPNQ DPLEASTGLV PLFGIDVWEH
     AYYLQYKNLR PSYVEAVWDI ANWNDISKRF ADAK
//
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