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Database: UniProt/TrEMBL
Entry: G3R9K6_GORGO
LinkDB: G3R9K6_GORGO
Original site: G3R9K6_GORGO 
ID   G3R9K6_GORGO            Unreviewed;       917 AA.
AC   G3R9K6;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   25-OCT-2017, entry version 45.
DE   SubName: Full=Hexokinase domain containing 1 {ECO:0000313|Ensembl:ENSGGOP00000012090};
GN   Name=HKDC1 {ECO:0000313|Ensembl:ENSGGOP00000012090};
OS   Gorilla gorilla gorilla (Western lowland gorilla).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Gorilla.
OX   NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000012090, ECO:0000313|Proteomes:UP000001519};
RN   [1] {ECO:0000313|Ensembl:ENSGGOP00000012090, ECO:0000313|Proteomes:UP000001519}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Scally A.;
RT   "Insights into the evolution of the great apes provided by the gorilla
RT   genome.";
RL   Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSGGOP00000012090}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the hexokinase family.
CC       {ECO:0000256|SAAS:SAAS00672880}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSGGOP00000012090}.
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DR   RefSeq; XP_004049563.1; XM_004049515.2.
DR   STRING; 9593.ENSGGOP00000012090; -.
DR   Ensembl; ENSGGOT00000012437; ENSGGOP00000012090; ENSGGOG00000012384.
DR   GeneID; 101127052; -.
DR   KEGG; ggo:101127052; -.
DR   CTD; 80201; -.
DR   GeneTree; ENSGT00390000017159; -.
DR   InParanoid; G3R9K6; -.
DR   KO; K00844; -.
DR   OMA; KIETRHV; -.
DR   OrthoDB; EOG091G08MD; -.
DR   TreeFam; TF314238; -.
DR   Proteomes; UP000001519; Chromosome 10.
DR   Bgee; ENSGGOG00000012384; -.
DR   GO; GO:0005739; C:mitochondrion; IEA:Ensembl.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0005536; F:glucose binding; IEA:InterPro.
DR   GO; GO:0004396; F:hexokinase activity; IEA:InterPro.
DR   GO; GO:0001678; P:cellular glucose homeostasis; IEA:InterPro.
DR   GO; GO:0006096; P:glycolytic process; IEA:UniProtKB-KW.
DR   InterPro; IPR001312; Hexokinase.
DR   InterPro; IPR019807; Hexokinase_BS.
DR   InterPro; IPR022673; Hexokinase_C.
DR   InterPro; IPR022672; Hexokinase_N.
DR   PANTHER; PTHR19443; PTHR19443; 4.
DR   Pfam; PF00349; Hexokinase_1; 2.
DR   Pfam; PF03727; Hexokinase_2; 2.
DR   PROSITE; PS00378; HEXOKINASE_1; 1.
DR   PROSITE; PS51748; HEXOKINASE_2; 2.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|SAAS:SAAS00672869};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001519};
KW   Glycolysis {ECO:0000256|SAAS:SAAS00672870};
KW   Kinase {ECO:0000256|SAAS:SAAS00672871};
KW   Nucleotide-binding {ECO:0000256|SAAS:SAAS00672883};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW   Transferase {ECO:0000256|SAAS:SAAS00672884}.
FT   DOMAIN       22    219       Hexokinase_1. {ECO:0000259|Pfam:PF00349}.
FT   DOMAIN      225    459       Hexokinase_2. {ECO:0000259|Pfam:PF03727}.
FT   DOMAIN      470    666       Hexokinase_1. {ECO:0000259|Pfam:PF00349}.
FT   DOMAIN      672    906       Hexokinase_2. {ECO:0000259|Pfam:PF03727}.
SQ   SEQUENCE   917 AA;  102529 MW;  C2E94544CE02FCC0 CRC64;
     MFAVHLMAFY FSKLKEDQIK KVDRFLYHMR LSDDTLLDIM RRFRAEMEKG LAKDTNPTAA
     VKMLPTFVRA IPDGSENGEF LSLDLGGSKF RVLKVQVAEE GKRHVQMESQ FYPTPNEIIR
     GNGTELFEYV ADCLADFMKT KDLKHKKLPL GLTFSFPCRQ TKLEEGVLLS WTKKFKARGV
     QDTDVVSRLT KAMRRHKDMD VDILALVNDT VGTMMTCAYD DPYCEVGVII GTGTNACYME
     DMSNIDLVEG DEGRMCINTE WGAFGDDGAL EDIRTEFDRE LDLGSLNPGK QLFEKMISGL
     YLGELVRLIL LKMAKAGLLF GGEKSSALHT KGKIETRHVA AMEKYKEGLA NTREILVDLG
     LEPSEADCIA VQHVCTIVSF RSANLCAAAL AAILTRLREN KKVERLRTTV GMDGTLYKIH
     PQYPKRLHKV VRKLVPSCDV RFLLSESGST KGAAMVTAVA SRLQAQRKQI DRVLALFQLT
     REQLVDVQAK MRAELEYGLK KKSHGLATVR MLPTYVCGLP DGTEKGKFLA LDLGGTNFRV
     LLVKIRSGRR SVRMYNKIFA IPLEIMQGTG EELFDHIVQC IADFLDYMGL KGASLPLGFT
     FSFPCRQMSI DKGTLIGWTK GFKATDCEGE DVVDMLREAI KRRNEFDLDI VAVVNDTVGT
     MMTCGYEDPN CEIGLIAGTG SNMCYMEDMR NIEMVEGGEG KMCINTEWGG FGDNGCIDDI
     RTRYDTEVDE GSLNPGKQRY EKMTSGMYLG EIVRQILIDL TKQGLLFRGQ ISERLRTRGI
     FETKFLSQIE SDRLALLQVR RILQQLGLDS TCEDSIVVKE VCGAVSRRAA QLCGAGLAAI
     VEKRREDQGL EHLRITVGVD GTLYKLHPHF SRILQETVKE LAPRCDVTFM LSEDGSGKGA
     ALITAVAKRL QQAQKEN
//
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