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Database: UniProt/TrEMBL
Entry: G3SVS6_LOXAF
LinkDB: G3SVS6_LOXAF
Original site: G3SVS6_LOXAF 
ID   G3SVS6_LOXAF            Unreviewed;       753 AA.
AC   G3SVS6;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   20-DEC-2017, entry version 44.
DE   SubName: Full=Proprotein convertase subtilisin/kexin type 1 {ECO:0000313|Ensembl:ENSLAFP00000004368};
GN   Name=PCSK1 {ECO:0000313|Ensembl:ENSLAFP00000004368};
OS   Loxodonta africana (African elephant).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX   NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000004368, ECO:0000313|Proteomes:UP000007646};
RN   [1] {ECO:0000313|Ensembl:ENSLAFP00000004368}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000004368};
RA   Di Palma F., Heiman D., Young S., Johnson J., Lander E.S.,
RA   Lindblad-Toh K.;
RT   "The Genome Sequence of Loxodonta africana (African elephant).";
RL   Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSLAFP00000004368}
RP   IDENTIFICATION.
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000004368};
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the peptidase S8 family.
CC       {ECO:0000256|RuleBase:RU003355, ECO:0000256|SAAS:SAAS00679558}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSLAFP00000004368}.
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DR   RefSeq; XP_003405038.1; XM_003404990.2.
DR   ProteinModelPortal; G3SVS6; -.
DR   STRING; 9785.ENSLAFP00000004368; -.
DR   MEROPS; S08.072; -.
DR   Ensembl; ENSLAFT00000005220; ENSLAFP00000004368; ENSLAFG00000005220.
DR   GeneID; 100677414; -.
DR   KEGG; lav:100677414; -.
DR   CTD; 5122; -.
DR   eggNOG; KOG3525; Eukaryota.
DR   eggNOG; COG1404; LUCA.
DR   eggNOG; COG4935; LUCA.
DR   GeneTree; ENSGT00750000117358; -.
DR   InParanoid; G3SVS6; -.
DR   KO; K01359; -.
DR   OMA; FEPRALK; -.
DR   OrthoDB; EOG091G05HI; -.
DR   TreeFam; TF314277; -.
DR   Proteomes; UP000007646; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:Ensembl.
DR   GO; GO:0043043; P:peptide biosynthetic process; IEA:Ensembl.
DR   GO; GO:0016486; P:peptide hormone processing; IEA:Ensembl.
DR   CDD; cd04059; Peptidases_S8_Protein_converta; 1.
DR   Gene3D; 2.60.120.260; -; 1.
DR   Gene3D; 3.40.50.200; -; 1.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR034182; Kexin/furin.
DR   InterPro; IPR002884; P_dom.
DR   InterPro; IPR009020; Peptidase/Inhibitor_I9.
DR   InterPro; IPR000209; Peptidase_S8/S53_dom.
DR   InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR   InterPro; IPR023827; Peptidase_S8_Asp-AS.
DR   InterPro; IPR022398; Peptidase_S8_His-AS.
DR   InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR   InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR   InterPro; IPR022005; Proho_convert.
DR   InterPro; IPR032815; S8_pro-domain.
DR   Pfam; PF01483; P_proprotein; 1.
DR   Pfam; PF00082; Peptidase_S8; 1.
DR   Pfam; PF12177; Proho_convert; 1.
DR   Pfam; PF16470; S8_pro-domain; 1.
DR   PRINTS; PR00723; SUBTILISIN.
DR   SUPFAM; SSF49785; SSF49785; 1.
DR   SUPFAM; SSF52743; SSF52743; 1.
DR   SUPFAM; SSF54897; SSF54897; 1.
DR   PROSITE; PS51829; P_HOMO_B; 1.
DR   PROSITE; PS00136; SUBTILASE_ASP; 1.
DR   PROSITE; PS00137; SUBTILASE_HIS; 1.
DR   PROSITE; PS00138; SUBTILASE_SER; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000007646};
KW   Hydrolase {ECO:0000256|RuleBase:RU003355,
KW   ECO:0000256|SAAS:SAAS00912743};
KW   Protease {ECO:0000256|RuleBase:RU003355,
KW   ECO:0000256|SAAS:SAAS00912730};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW   Serine protease {ECO:0000256|RuleBase:RU003355,
KW   ECO:0000256|SAAS:SAAS00912691}; Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     27       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        28    753       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003454262.
FT   DOMAIN      460    597       P/Homo B. {ECO:0000259|PROSITE:PS51829}.
SQ   SEQUENCE   753 AA;  83918 MW;  06B4F199BC0889DB CRC64;
     MELRPWTLQG TALALFCAWC ALNSVEAKRQ FVNEWAAEIS GGPEAASAIA EELGYDLLGQ
     IGSLENHYLF KHKNHPRRSR RSAFHITKRL SDDERVIWAE QQYEKERSKR TALKDSALNL
     FNDPMWNQQW YLQDTRMTAA LPKLDLHVIP VWQKGITGKG VVITVLDDGL EWNHTDIYAN
     YDPEASYDFN DNDHDPFPRY DPTNENKHGT RCAGEIAMQA NNNKCGVGVA YNSKVGGIRM
     LDGIVTDAIE ASSIGFNPGH VDIYSASWGP NDDGKTVEGP GRLAQKAFEY GVKQGRQGKG
     SIFVWASGNG GRQGDNCDCD GYTDSIYTIS ISSASQQGLS PWYAEKCSST LATSYSSGDY
     TDQRITSADL HNDCTETHTG TSASAPLAAG IFALALEANP NLTWRDMQHL VVWTSEYDPL
     ANNPGWKKNG AGLMVNSRFG FGLLNAKALV DLADPRTWSS VSEKKECVVK DNDFEPRALK
     ANGEVIIEIP TRACEGQENA IKSLEHVQFE ATIEYSRRGD LHVTLTSAAG TSTVLLAERE
     RDTSPNGFKN WDFMSVHTWG ENPVGTWTLR ITDMSGRIQN EGRIVNWKLI LHGTSSQPEH
     MKQPRVYTSY NTVQNDRRGV EKMVDAGEEQ PTPENLKEKP LVAKSPSSSS VGNRRDEVAE
     GAPSEAMLRL LQSAFSKNLP PKQSPKKSPS AKVNIPYENF YEALEKLNKP SQLRDPEDSV
     YNDYVDVFYN TKPYKHRDDR LLQALVDILN EEN
//
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