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Database: UniProt/TrEMBL
Entry: G3SYA6_LOXAF
LinkDB: G3SYA6_LOXAF
Original site: G3SYA6_LOXAF 
ID   G3SYA6_LOXAF            Unreviewed;       883 AA.
AC   G3SYA6;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   07-JUN-2017, entry version 32.
DE   RecName: Full=Histone-lysine N-methyltransferase {ECO:0000256|PROSITE-ProRule:PRU00903};
DE            EC=2.1.1.43 {ECO:0000256|PROSITE-ProRule:PRU00903};
GN   Name=KMT5B {ECO:0000313|Ensembl:ENSLAFP00000005452};
OS   Loxodonta africana (African elephant).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX   NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000005452, ECO:0000313|Proteomes:UP000007646};
RN   [1] {ECO:0000313|Ensembl:ENSLAFP00000005452}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000005452};
RA   Di Palma F., Heiman D., Young S., Johnson J., Lander E.S.,
RA   Lindblad-Toh K.;
RT   "The Genome Sequence of Loxodonta africana (African elephant).";
RL   Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSLAFP00000005452}
RP   IDENTIFICATION.
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000005452};
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY: S-adenosyl-L-methionine + L-lysine-[histone] =
CC       S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].
CC       {ECO:0000256|PROSITE-ProRule:PRU00903}.
CC   -!- SIMILARITY: Belongs to the class V-like SAM-binding
CC       methyltransferase superfamily. Histone-lysine methyltransferase
CC       family. Suvar4-20 subfamily. {ECO:0000256|PROSITE-
CC       ProRule:PRU00903}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSLAFP00000005452}.
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DR   RefSeq; XP_003419589.1; XM_003419541.2.
DR   STRING; 9785.ENSLAFP00000005452; -.
DR   Ensembl; ENSLAFT00000006496; ENSLAFP00000005452; ENSLAFG00000006490.
DR   GeneID; 100671600; -.
DR   KEGG; lav:100671600; -.
DR   CTD; 51111; -.
DR   eggNOG; KOG2589; Eukaryota.
DR   eggNOG; ENOG410XPH8; LUCA.
DR   GeneTree; ENSGT00520000055640; -.
DR   InParanoid; G3SYA6; -.
DR   KO; K11429; -.
DR   OMA; SGCLTRH; -.
DR   TreeFam; TF106433; -.
DR   Proteomes; UP000007646; Unassembled WGS sequence.
DR   GO; GO:0000780; C:condensed nuclear chromosome, centromeric region; IEA:Ensembl.
DR   GO; GO:0042799; F:histone methyltransferase activity (H4-K20 specific); IEA:UniProtKB-UniRule.
DR   GO; GO:0034773; P:histone H4-K20 trimethylation; IEA:UniProtKB-UniRule.
DR   InterPro; IPR025790; Hist-Lys_N-MTase_Suvar4-20.
DR   InterPro; IPR001214; SET_dom.
DR   Pfam; PF00856; SET; 1.
DR   SMART; SM00317; SET; 1.
DR   PROSITE; PS51570; SAM_MT43_SUVAR420_2; 1.
DR   PROSITE; PS50280; SET; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000007646};
KW   Methyltransferase {ECO:0000256|PROSITE-ProRule:PRU00903};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW   S-adenosyl-L-methionine {ECO:0000256|PROSITE-ProRule:PRU00903};
KW   Transferase {ECO:0000256|PROSITE-ProRule:PRU00903}.
FT   DOMAIN      193    308       SET. {ECO:0000259|PROSITE:PS50280}.
SQ   SEQUENCE   883 AA;  98671 MW;  2184257FA26D1027 CRC64;
     MKWLGDSKNM VVNGRRNGGK LSDDHPQTPS RFPHAGKDTL KAGRSAVDRR SSRCNGNSGF
     EGQSRYVPSS GMSAKELCEN DDLATSLVLD PYLGFQTHKM NTSAFPSRSS RHFSKSDSFP
     HSNPVRFRPI KGRQEELKEV IERFKKDEHL EKAFKCLTSG EWARHYFLNK NKMQEKLFKE
     HVFIYLRMFA TDSGFEILPC NRYSSEQNGA KIVATKEWKR NDKIELLVGC IAELSEIEEN
     MLLRHGENDF SVMYSTRKNC AQLWLGPAAF INHDCRPNCK FVSTGRDTAC VKALRDIEPG
     EEISCYYGDG FFGENNEFCE CYTCERRGTG AFKSRAGLPA PAPVINSKYG LRETDKRLNR
     LKKLGDSSKN SDSQSVSSNT DADTTQEKNN ATSNRKSSVG VKKNSKNRTL TRQSMSRIPA
     SSNSTSSKLT HMNNSRVPKK LKKPAKPLLS KIKLRNHCKR LEQKTASRKL EMGNLVLKEP
     KVVLYKNLPI KKDKELEGPV QAGVASGCLT RHAAREHRQN SVRGAHTRGE GSPCSYITRR
     SVRTRMSLKE ASEVRLDPDA ADGLRDSPVE PCADEDEQPV PGLQEENLTR ETTQKGDSQC
     HKSDTTMSKK KSRQGKLVKQ FTKMEESAPG RDSPGRDSSG PDVPGSHSDQ GEHSGTGGAP
     VGYTDCAPSP VGCSIVTSDS FKTKDGFRTA RSRKKRRITR YDAQLILENN SGIPKLTLRR
     RHDSSSKTND QENDGMNSSK ISIKLSKDHE NDNNLYVAKL NNGFNSGSGG SSTKLKIQLK
     RDEEGRGSYA EGLHENGVCC SDPLSLLESR MEVDDYGQYE EESTDDPSSS EGDEEEDDYD
     DDFEDDFIPL PPAKRLRLIV GKDSIDIDIS SRRREDQSLR LNA
//
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