UniProt/TrEMBL: G3WJK8

Database: UniProt/TrEMBL
Entry: G3WJK8_SARHA

LinkDB:  G3WJK8_SARHA 
Original site:  G3WJK8_SARHA

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Ontology (8)   
   GO (8)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (5)   
   KEGG GENES (1)   
   NCBI-Gene (1)   
   ENSEMBL-UP (3)   
Protein sequence (1)   
   RefSeq(pep) (1)   
Protein domain (6)   
   InterPro (4)   
   Pfam (1)   
   PROSITE (1)   
Literature (1)   
   PubMed (1)   
All databases (22)   

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ID   G3WJK8_SARHA            Unreviewed;       587 AA.
AC   G3WJK8;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   27-MAR-2024, entry version 63.
DE   RecName: Full=Glutamate decarboxylase 2 {ECO:0000256|ARBA:ARBA00040577};
DE            EC=4.1.1.15 {ECO:0000256|ARBA:ARBA00012421};
DE   AltName: Full=65 kDa glutamic acid decarboxylase {ECO:0000256|ARBA:ARBA00043203};
DE   AltName: Full=Glutamate decarboxylase 65 kDa isoform {ECO:0000256|ARBA:ARBA00041381};
GN   Name=GAD2 {ECO:0000313|Ensembl:ENSSHAP00000015613.1};
OS   Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX   NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000015613.1, ECO:0000313|Proteomes:UP000007648};
RN   [1] {ECO:0000313|Ensembl:ENSSHAP00000015613.1, ECO:0000313|Proteomes:UP000007648}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA   Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA   Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA   Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA   Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA   Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA   Jones M.E., Schuster S.C.;
RT   "Genetic diversity and population structure of the endangered marsupial
RT   Sarcophilus harrisii (Tasmanian devil).";
RL   Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN   [2] {ECO:0000313|Ensembl:ENSSHAP00000015613.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: Catalyzes the production of GABA.
CC       {ECO:0000256|ARBA:ARBA00037048}.
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC         Evidence={ECO:0000256|ARBA:ARBA00001933,
CC         ECO:0000256|PIRSR:PIRSR602129-50, ECO:0000256|RuleBase:RU000382};
CC   -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004193};
CC       Lipid-anchor {ECO:0000256|ARBA:ARBA00004193}. Cytoplasm, cytosol
CC       {ECO:0000256|ARBA:ARBA00004514}. Cytoplasmic vesicle
CC       {ECO:0000256|ARBA:ARBA00004541}. Golgi apparatus membrane
CC       {ECO:0000256|ARBA:ARBA00004255}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004255}; Cytoplasmic side
CC       {ECO:0000256|ARBA:ARBA00004255}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004635}; Lipid-anchor
CC       {ECO:0000256|ARBA:ARBA00004635}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC       {ECO:0000256|ARBA:ARBA00004287}. Presynaptic cell membrane
CC       {ECO:0000256|ARBA:ARBA00037840}; Lipid-anchor
CC       {ECO:0000256|ARBA:ARBA00037840}. Vesicle
CC       {ECO:0000256|ARBA:ARBA00004373}.
CC   -!- SIMILARITY: Belongs to the group II decarboxylase family.
CC       {ECO:0000256|ARBA:ARBA00009533, ECO:0000256|RuleBase:RU000382}.
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DR   RefSeq; XP_003771904.1; XM_003771856.1.
DR   AlphaFoldDB; G3WJK8; -.
DR   STRING; 9305.ENSSHAP00000015613; -.
DR   Ensembl; ENSSHAT00000015741.2; ENSSHAP00000015613.1; ENSSHAG00000013305.2.
DR   GeneID; 100920746; -.
DR   KEGG; shr:100920746; -.
DR   CTD; 2572; -.
DR   eggNOG; KOG0629; Eukaryota.
DR   GeneTree; ENSGT00940000157951; -.
DR   HOGENOM; CLU_011856_0_0_1; -.
DR   InParanoid; G3WJK8; -.
DR   OMA; AGMVIFK; -.
DR   OrthoDB; 888358at2759; -.
DR   TreeFam; TF314688; -.
DR   Proteomes; UP000007648; Unassembled WGS sequence.
DR   GO; GO:0030424; C:axon; IEA:Ensembl.
DR   GO; GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-KW.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0042734; C:presynaptic membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016831; F:carboxy-lyase activity; IEA:UniProtKB-KW.
DR   GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR   GO; GO:0019752; P:carboxylic acid metabolic process; IEA:InterPro.
DR   CDD; cd06450; DOPA_deC_like; 1.
DR   Gene3D; 3.90.1150.170; -; 1.
DR   Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR   InterPro; IPR002129; PyrdxlP-dep_de-COase.
DR   InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR   InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR   InterPro; IPR021115; Pyridoxal-P_BS.
DR   PANTHER; PTHR45677:SF11; GLUTAMATE DECARBOXYLASE 2; 1.
DR   PANTHER; PTHR45677; GLUTAMATE DECARBOXYLASE-RELATED; 1.
DR   Pfam; PF00282; Pyridoxal_deC; 1.
DR   SUPFAM; SSF53383; PLP-dependent transferases; 1.
DR   PROSITE; PS00392; DDC_GAD_HDC_YDC; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW   Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW   Decarboxylase {ECO:0000256|ARBA:ARBA00022793};
KW   Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW   Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW   Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU000382};
KW   Membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Palmitate {ECO:0000256|ARBA:ARBA00023139};
KW   Pyridoxal phosphate {ECO:0000256|PIRSR:PIRSR602129-50,
KW   ECO:0000256|RuleBase:RU000382};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007648};
KW   Synapse {ECO:0000256|ARBA:ARBA00023018}.
FT   REGION          1..25
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         398
FT                   /note="N6-(pyridoxal phosphate)lysine"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR602129-50"
SQ   SEQUENCE   587 AA;  65773 MW;  B7E0FD32619CB0EE CRC64;
     MASTGSGFWS FGSEDGSGDP ENPSTARAWC QVAQKFTGGI GNKLCALLYG DAEKPMETSG
     SEKETQGSAD KKTVCTCNQK PCSCPKTDLN YACLHSTDLL PACNGEVATL SFLQDVMDIL
     LQYVVKSFDR STKVIDFHYP NELLQEHNWE LADQPQTLEE ILSNCRTTLK YAIKTGHPRY
     FNQLSTGLDM VGLAADWLTS TANTNMFTYE IAPVFVLLEY VTLRKMREIV GWPGGSGDGI
     FSPGGAISNM YAMLIARFKM FPEVKEKGMA AIPRLVAFTS EHSHFSVKKG AAALGIGTDS
     VILIKCDERG KMIPSDLERR IVEAKQKGFV PFLVSATAGT TVYGAFDPLL AIADICKKYK
     IWMHVDAAWG GGLLMSRKHK WKLNGVERAN SVTWNPHKMM GVPLQCSALL VREEGLMQSC
     NQMHASYLFQ QDKHYDLSYD TGDKALQCGR HVDVFKLWLM WRAKGTIGFE AQIDKCLELA
     EYLYNLIKNR EGYEMVFDGK PQHTNVCFWY IPPSLRHLED NEERMSRLLK VAPVIKARMM
     EYGTTMVSYQ PLGDKVNFFR MVISNPAATH QDIDFLIEEI ERLGQDL
//

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